Academic Journal
Clinical and radiographic outcomes and associated factors of iRoot BP plus apical barrier treatment in permanent teeth with open apices and periapical lesions: a retrospective study.
| Τίτλος: | Clinical and radiographic outcomes and associated factors of iRoot BP plus apical barrier treatment in permanent teeth with open apices and periapical lesions: a retrospective study. |
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| Συγγραφείς: | Wang J; College & Hospital of Stomatology, Anhui Medical University, Anhui Provincial Key Laboratory of Oral Diseases Research, 230032, Hefei, China., Xiang K; Teaching Management Office, College of Stomatology, Anhui Medical University, Hefei, China., Sun C; College & Hospital of Stomatology, Anhui Medical University, Anhui Provincial Key Laboratory of Oral Diseases Research, 230032, Hefei, China., Ren T; College & Hospital of Stomatology, Anhui Medical University, Anhui Provincial Key Laboratory of Oral Diseases Research, 230032, Hefei, China., Zhang H; College & Hospital of Stomatology, Anhui Medical University, Anhui Provincial Key Laboratory of Oral Diseases Research, 230032, Hefei, China. toothyan@126.com. |
| Πηγή: | Clinical oral investigations [Clin Oral Investig] 2026 Feb 28; Vol. 30 (3). Date of Electronic Publication: 2026 Feb 28. |
| Τύπος έκδοσης: | Journal Article |
| Γλώσσα: | English |
| Στοιχεία περιοδικού: | Publisher: Springer-Verlag Country of Publication: Germany NLM ID: 9707115 Publication Model: Electronic Cited Medium: Internet ISSN: 1436-3771 (Electronic) Linking ISSN: 14326981 NLM ISO Abbreviation: Clin Oral Investig Subsets: MEDLINE |
| Imprint Name(s): | Publication: Berlin : Springer-Verlag Original Publication: Berlin : Springer, c1997- |
| Ιατρικοί όροι (MeSH): | Silicates*/therapeutic use , Tooth Apex*/diagnostic imaging , Periapical Diseases*/diagnostic imaging , Periapical Diseases*/therapy , Apexification*/methods , Root Canal Filling Materials*/therapeutic use , Dentition, Permanent*, Dental Pulp Necrosis/diagnostic imaging ; Dental Pulp Necrosis/therapy ; Retrospective Studies ; Humans ; Male ; Child ; Adolescent ; Young Adult ; Adult ; Middle Aged ; Radiography, Dental ; Female |
| Περίληψη: | OBJECTIVE: To evaluate clinical and radiographic outcomes of iRoot BP Plus apical barrier treatment in permanent teeth with open apices and periapical lesions and to explore associated factors. METHODS: Permanent teeth exhibiting pulp necrosis and open apices treated with iRoot BP Plus apical barrier were retrospectively included with follow-up ≥ 12 months. Treatment outcomes were determined through clinical examinations and radiographic assessments, with results classified as healed, healing, or failure. Quantitative changes in root length, root width, and apical diameter were measured on paired radiographs. Associations between baseline variables and outcomes were examined using chi-square or Fisher’s exact tests. RESULTS: A total of 54 teeth were included in the final evaluation, with a median follow-up period of 18.5 months (minimum 12 months, maximum 60 months). At final follow-up, 23 teeth (42.6%) were classified as healed, 29 (53.7%) as healing, and 2 (3.7%) as failure. Favorable outcomes (healed and healing) were observed in 52 teeth (96.3%); most teeth (52/54) were asymptomatic. Radiographs showed substantial reduction or resolution of periapical lesions. Periapical index (PAI) was significantly associated with treatment outcome (P < 0.05). Quantitative radiographic measurements indicated increased root length and root width with a reduction in apical diameter during follow-up. CONCLUSION: In this retrospective cohort, iRoot BP Plus apical barrier treatment showed favorable clinical and radiographic outcomes in permanent teeth with open apices and periapical lesions. CLINICAL RELEVANCE: In this study, PAI was associated with treatment outcomes, which may help clinicians in case assessment and follow-up planning. |
| Competing Interests: | Declarations. Ethics approval and consent to participate: All procedures described in this manuscript have been reviewed and approved by the Ethical Committee of the Anhui Stomatological Hospital (approval: NoT2024039). Informed consent was received in writing from all participants. Competing interests: The authors declare no competing interests. |
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| Grant Information: | KJ2020A0165 Natural Science Foundation of Universities of Anhui province; No.2023xkfyts04, 2022xkfyts10 Research improvement program in Stomatologic Hospital and College of Anhui Medical University; No. 2024Ab019 Anhui Provincial Health and Health Research Project |
| Contributed Indexing: | Keywords: Apical barrier; IRoot BP plus; Open apex; Periapical lesions |
| Substance Nomenclature: | 0 (iRoot BP Plus) 0 (Silicates) 0 (Root Canal Filling Materials) |
| Entry Date(s): | Date Created: 20260227 Date Completed: 20260921 Latest Revision: 20261009 |
| Update Code: | 20261009 |
| DOI: | 10.1007/s00784-026-06764-4 |
| PMID: | 41760844 |
| Βάση Δεδομένων: | MEDLINE |
| ISSN: | 1436-3771 |
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| DOI: | 10.1007/s00784-026-06764-4 |