Academic Journal
The Neuroprotective Effects of Alpha-Tocopherol as an Anti-Inflammatory Agent: Mechanistic Insights and Therapeutic Challenges.
| Τίτλος: | The Neuroprotective Effects of Alpha-Tocopherol as an Anti-Inflammatory Agent: Mechanistic Insights and Therapeutic Challenges. |
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| Συγγραφείς: | Seese MH; Brown Foundation Institute of Molecular Medicine, McGovern Medical School, University of Texas Health Science Center at Houston (UTHealth), Houston, TX 77030, USA., Xu Y; Brown Foundation Institute of Molecular Medicine, McGovern Medical School, University of Texas Health Science Center at Houston (UTHealth), Houston, TX 77030, USA.; MD Anderson Cancer Center, UTHealth Houston Graduate School for Biomedical Sciences, Houston, TX 77030, USA. |
| Πηγή: | Nutrients [Nutrients] 2026 Feb 19; Vol. 18 (4). Date of Electronic Publication: 2026 Feb 19. |
| Τύπος έκδοσης: | Journal Article; Review |
| Γλώσσα: | English |
| Στοιχεία περιοδικού: | Publisher: MDPI Publishing Country of Publication: Switzerland NLM ID: 101521595 Publication Model: Electronic Cited Medium: Internet ISSN: 2072-6643 (Electronic) Linking ISSN: 20726643 NLM ISO Abbreviation: Nutrients Subsets: MEDLINE |
| Imprint Name(s): | Original Publication: Basel, Switzerland : MDPI Publishing |
| Ιατρικοί όροι (MeSH): | alpha-Tocopherol*/pharmacology , alpha-Tocopherol*/therapeutic use , Neuroprotective Agents*/pharmacology , Neuroprotective Agents*/therapeutic use , Anti-Inflammatory Agents*/pharmacology , Anti-Inflammatory Agents*/therapeutic use , Neuroinflammatory Diseases*/drug therapy, Brain/drug effects ; Brain/metabolism ; Antioxidants/pharmacology ; Animals ; Humans |
| Περίληψη: | Vitamin E (alpha-tocopherol, αToc), an antioxidant fat-soluble vitamin that prevents lipid peroxidation and modulates pro-inflammatory cytokine production, is well-known to be critical for neuroprotection. However, the underlying mechanism remains poorly understood. Accumulating evidence demonstrates that αToc influences neuroinflammatory processes. Here, we review recent research progress on the effects of αToc on neuroinflammation. Preclinical studies included in this narrative review were identified through PubMed searches using the keywords "alpha-tocopherol AND neuroinflammation or alpha-tocopherol AND brain AND inflammation". While many studies support a neuroprotective role of αToc, the magnitude and direction of its effects vary substantially depending on dosage, route of administration, types of αToc substance, sex, and experimental design. The conclusions of this review apply only to αToc and should not be extrapolated to other vitamin E isoforms. Collectively, these findings suggest that αToc exerts beneficial effects primarily under specific conditions, and that a deeper understanding of the neural mechanisms mediating its neuroprotective actions may facilitate the optimization of therapeutic strategies for neuroinflammatory diseases. |
| Contributed Indexing: | Keywords: alpha-tocopherol; brain health; neuroinflammation; vitamin E |
| Substance Nomenclature: | H4N855PNZ1 (alpha-Tocopherol) 0 (Neuroprotective Agents) 0 (Anti-Inflammatory Agents) 0 (Antioxidants) |
| Entry Date(s): | Date Created: 20260227 Date Completed: 20260709 Latest Revision: 20260709 |
| Update Code: | 20260711 |
| PubMed Central ID: | PMC12943326 |
| DOI: | 10.3390/nu18040676 |
| PMID: | 41754193 |
| Βάση Δεδομένων: | MEDLINE |
| ISSN: | 2072-6643 |
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| DOI: | 10.3390/nu18040676 |