Academic Journal
Neural and Oxidative-Stress Parameters as Early Biomarkers of Hand-Arm Vibration Syndrome.
| Τίτλος: | Neural and Oxidative-Stress Parameters as Early Biomarkers of Hand-Arm Vibration Syndrome. |
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| Συγγραφείς: | Tang Z; School of Public Health, Guangdong Pharmaceutical University, Haizhu District, Guangzhou 510006, China.; Guangdong Provincial Engineering Research Center of Public Health Detection and Assessment, Guangzhou 511400, China., Chen Q; School of Public Health, Guangdong Pharmaceutical University, Haizhu District, Guangzhou 510006, China.; Guangdong Provincial Engineering Research Center of Public Health Detection and Assessment, Guangzhou 511400, China., Li J; School of Public Health, Guangdong Pharmaceutical University, Haizhu District, Guangzhou 510006, China.; Guangdong Provincial Engineering Research Center of Public Health Detection and Assessment, Guangzhou 511400, China., Zhou K; School of Public Health, Guangdong Pharmaceutical University, Haizhu District, Guangzhou 510006, China.; Guangdong Provincial Engineering Research Center of Public Health Detection and Assessment, Guangzhou 511400, China., Zeng F; School of Public Health, Guangdong Pharmaceutical University, Haizhu District, Guangzhou 510006, China.; Guangdong Provincial Engineering Research Center of Public Health Detection and Assessment, Guangzhou 511400, China., Yang H; School of Public Health, Guangdong Pharmaceutical University, Haizhu District, Guangzhou 510006, China.; Guangdong Provincial Engineering Research Center of Public Health Detection and Assessment, Guangzhou 511400, China. |
| Πηγή: | Biomolecules [Biomolecules] 2026 Feb 03; Vol. 16 (2). Date of Electronic Publication: 2026 Feb 03. |
| Τύπος έκδοσης: | Journal Article |
| Γλώσσα: | English |
| Στοιχεία περιοδικού: | Publisher: MDPI Country of Publication: Switzerland NLM ID: 101596414 Publication Model: Electronic Cited Medium: Internet ISSN: 2218-273X (Electronic) Linking ISSN: 2218273X NLM ISO Abbreviation: Biomolecules Subsets: MEDLINE |
| Imprint Name(s): | Original Publication: Basel, Switzerland : MDPI, 2011- |
| Ιατρικοί όροι (MeSH): | Hand-Arm Vibration Syndrome*/blood , Hand-Arm Vibration Syndrome*/diagnosis , Hand-Arm Vibration Syndrome*/metabolism , Biomarkers*/blood , Oxidative Stress*, Malondialdehyde/blood ; Superoxide Dismutase/blood ; Vibration/adverse effects ; Glutathione/blood ; Glutathione Peroxidase/blood ; Interleukin-10/blood ; S100 Calcium Binding Protein beta Subunit/blood ; Creatine Kinase/blood ; Humans ; Male ; Adult ; ROC Curve ; Middle Aged |
| Περίληψη: | Objective: Investigate alterations in the expression of specific and sensitive biomarkers of oxidative stress (OS) in blood and in nerves during hand-arm vibration syndrome (HAVS) progression. Methods: Fifty workers with vibration-induced white finger (VWF) symptoms and exposure to hand vibration were selected from a Chinese factory by judgment sampling. Fifty workers not exposed to hand vibration served as a control group. Expression of OS-related indices in blood was measured. The same method was used to select 40 workers separately for the determination of neurological indicators. Blood samples were collected from participants, and expression of indicators in plasma was measured by ELISAs. Results: The receiver operating characteristic (ROC) curves of OS-related indices and neurological indices were analyzed to assess their diagnostic sensitivity to VWF. Among OS indices, the area under the ROC curve (AUC) of malondialdehyde (MDA), superoxide dismutase (SOD), glutathione (GSH), and glutathione peroxidase (GSH-PX) was >0.9. With regard to the neurological indices, the AUC of S100β, interleukin (IL)-10, creatine kinase (CK), and growth differentiation factor (GDF)-15 was 0.7-0.9. Conclusions: MDA, SOD, GSH, GSH-PX, S100β, IL-10, CK, and GDF-15 could be diagnostic markers for VWF. |
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| Grant Information: | 82204007 National Natural Science Foundation of China; 2024A1515013049 Guangdong Basic and Applied Basic Research Foundation |
| Contributed Indexing: | Keywords: hand–arm vibration syndrome; neurological indices; oxidative stress; vascular injury; vibration-induced white finger |
| Substance Nomenclature: | 0 (Biomarkers) 4Y8F71G49Q (Malondialdehyde) EC 1.15.1.1 (Superoxide Dismutase) GAN16C9B8O (Glutathione) EC 1.11.1.9 (Glutathione Peroxidase) 130068-27-8 (Interleukin-10) 0 (S100 Calcium Binding Protein beta Subunit) EC 2.7.3.2 (Creatine Kinase) |
| Entry Date(s): | Date Created: 20260227 Date Completed: 20260709 Latest Revision: 20260813 |
| Update Code: | 20260813 |
| PubMed Central ID: | PMC12938795 |
| DOI: | 10.3390/biom16020238 |
| PMID: | 41750308 |
| Βάση Δεδομένων: | MEDLINE |
| ISSN: | 2218-273X |
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| DOI: | 10.3390/biom16020238 |