The Association between Polypharmacy, Low Appendicular Skeletal Muscle Mass Index, and Physical Performance: A Cross-Sectional Study.

Λεπτομέρειες βιβλιογραφικής εγγραφής
Τίτλος:	The Association between Polypharmacy, Low Appendicular Skeletal Muscle Mass Index, and Physical Performance: A Cross-Sectional Study.
Συγγραφείς:	Hung CD; Department of Family Medicine, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung City, Taiwan., Chang CW; Department of Medical Education, Kaohsiung Chang Gung Memorial Hospital, Kaohsiung City, Taiwan.; Department of Occupational Medicine, Kaohsiung Municipal Siaogang Hospital, Kaohsiung Medical University, Kaohsiung City, Taiwan., Tu HP; Department of Public Health and Environmental Medicine, School of Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung City, Taiwan., Kung YH; Department of Nursing, Kaohsiung Municipal Siaogang Hospital, Kaohsiung Medical University, Kaohsiung City, Taiwan., Tsai PY; Department of Nursing, Kaohsiung Municipal Siaogang Hospital, Kaohsiung Medical University, Kaohsiung City, Taiwan., Lin GC; Department of Occupational Medicine, Kaohsiung Municipal Siaogang Hospital, Kaohsiung Medical University, Kaohsiung City, Taiwan., Liu YF; Department of Physical Medicine and Rehabilitation, Kaohsiung Municipal Hsiao-Kang Hospital, Kaohsiung Medical University, Kaohsiung City, Taiwan., Chen HS; Pharmacy Department, Kaohsiung Municipal Siaogang Hospital, Kaohsiung Medical University, Kaohsiung City, Taiwan., Yang CC; Department of Occupational Medicine, Kaohsiung Municipal Siaogang Hospital, Kaohsiung Medical University, Kaohsiung City, Taiwan, abcmacoto@gmail.com.; Department of Public Health and Environmental Medicine, School of Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung City, Taiwan, abcmacoto@gmail.com.; Department of Occupational and Environmental Medicine, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung City, Taiwan, abcmacoto@gmail.com.; Research Center for Precision Environmental Medicine, Kaohsiung Medical University, Kaohsiung City, Taiwan, abcmacoto@gmail.com., Lee CY; Department of Family Medicine, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung City, Taiwan., Chuang HY; Department of Public Health and Environmental Medicine, School of Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung City, Taiwan.; Department of Occupational and Environmental Medicine, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung City, Taiwan.; Research Center for Precision Environmental Medicine, Kaohsiung Medical University, Kaohsiung City, Taiwan., Hung CH; Research Center for Precision Environmental Medicine, Kaohsiung Medical University, Kaohsiung City, Taiwan.; Department of Pediatrics, Kaohsiung Municipal Siaogang Hospital, Kaohsiung Medical University, Kaohsiung City, Taiwan.
Πηγή:	Gerontology [Gerontology] 2026; Vol. 72 (5), pp. 354-362. Date of Electronic Publication: 2026 Feb 26.
Τύπος έκδοσης:	Journal Article
Γλώσσα:	English
Στοιχεία περιοδικού:	Publisher: Karger Country of Publication: Switzerland NLM ID: 7601655 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1423-0003 (Electronic) Linking ISSN: 0304324X NLM ISO Abbreviation: Gerontology Subsets: MEDLINE
Imprint Name(s):	Original Publication: Basel, New York, Karger.
Ιατρικοί όροι (MeSH):	Muscle, Skeletal/physiopathology , Sarcopenia/physiopathology , Polypharmacy* , Physical Functional Performance*, Geriatric Assessment/methods ; Aging/physiology ; Humans ; Cross-Sectional Studies ; Female ; Male ; Aged ; Middle Aged ; Body Composition
Περίληψη:	Introduction: In response to the rapidly growing elderly population, geriatric syndromes such as frailty, polypharmacy, and sarcopenia have gained significant attention due to their impact on aging-related health outcomes. To prevent functional decline, it is crucial to understand the relationship between physical performance and other potential confounding factors. This study aims to investigate how polypharmacy and other factors relate to physical performance. Methods: This cross-sectional study included 445 participants aged over 20, surveyed via questionnaire. Polypharmacy was defined as the daily use of 8 or more pills. Body composition was assessed using bioelectrical impedance analysis, and physical performance was measured via the Time-Up-and-Go (TUG) and five times Sit-to-Stand (5xSTS) tests. Results: The average age of participants was 64.22 years, with 11.0% on polypharmacy. The mean appendicular skeletal muscle mass index, TUG test, and 5xSTS test were 7.40 kg/m2, 8.29 seconds, and 9.33 seconds, respectively. Both physical performance tests correlated positively with age, low education, and polypharmacy and negatively with appendicular skeletal muscle mass index. Polypharmacy, low muscle mass, and lower educational levels were associated with poorer physical performance. Conclusion: These findings highlight the importance of early prevention strategies to address polypharmacy, muscle loss, and low education, all of which are potentially modifiable risk factors. Poorer physical performance was linked to polypharmacy, low muscle mass, and lower educational levels, suggesting a need for additional research into these contributing risk factors. (© 2026 S. Karger AG, Basel.)
Contributed Indexing:	Keywords: Appendicular skeletal muscle mass index; Five times Sit-to-Stand test; Physical performance; Polypharmacy; Timed-Up-and-Go test
Entry Date(s):	Date Created: 20260226 Date Completed: 20260709 Latest Revision: 20260709
Update Code:	20260711
DOI:	10.1159/000551103
PMID:	41746861
Βάση Δεδομένων:	MEDLINE

Περιγραφή
ISSN:	1423-0003
DOI:	10.1159/000551103