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Fatty Acid-enriched Euphorbia neriifolia Alleviates the NPIP-induced Lung Cancer Via Modulating Oxidative Stress and Apoptosis in Swiss Albino Mice.

Λεπτομέρειες βιβλιογραφικής εγγραφής
Τίτλος: Fatty Acid-enriched Euphorbia neriifolia Alleviates the NPIP-induced Lung Cancer Via Modulating Oxidative Stress and Apoptosis in Swiss Albino Mice.
Συγγραφείς: Chaudhary P; Department of Bioscience and Biotechnology, Banasthali Vidyapith, Banasthali, Jaipur, 304022, Rajasthan, India.; Centre for Herbal Pharmacology and Environmental Sustainability, Chettinad Hospital and Research Institute, Chettinad Academy of Research and Education, Kelambakkam, 603103, Tamil Nadu, India., Meena M; Laboratory of Phytopathology and Microbial Biotechnology, Department of Botany, Mohanlal Sukhadia University, Udaipur, 313001, Rajasthan, India., Singh D; Department of Chemistry, Mohanlal Sukhadia University, Udaipur, 313001, Rajasthan, India., Janmeda P; Department of Bioscience and Biotechnology, Banasthali Vidyapith, Banasthali, Jaipur, 304022, Rajasthan, India. pracheta@banasthali.in.
Πηγή: Cell biochemistry and biophysics [Cell Biochem Biophys] 2026 Jun; Vol. 84 (2), pp. 2545-2573. Date of Electronic Publication: 2026 Feb 25.
Τύπος έκδοσης: Journal Article
Γλώσσα: English
Στοιχεία περιοδικού: Publisher: Humana Press Country of Publication: United States NLM ID: 9701934 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1559-0283 (Electronic) Linking ISSN: 10859195 NLM ISO Abbreviation: Cell Biochem Biophys Subsets: MEDLINE
Imprint Name(s): Original Publication: Totowa, NJ : Humana Press, c1996-
Ιατρικοί όροι (MeSH): Apoptosis*/drug effects , Lung Neoplasms*/chemically induced , Lung Neoplasms*/pathology , Lung Neoplasms*/drug therapy , Lung Neoplasms*/metabolism , Oxidative Stress*/drug effects , Euphorbia*/chemistry , Euphorbia*/metabolism , Plant Extracts*/pharmacology , Plant Extracts*/chemistry , Plant Extracts*/therapeutic use , Linoleic Acid*/pharmacology , Linoleic Acid*/chemistry, Tumor Suppressor Protein p53/metabolism ; Plant Leaves/chemistry ; Plant Leaves/metabolism ; Cell Proliferation/drug effects ; Antioxidants/metabolism ; Cell Survival/drug effects ; Antineoplastic Agents, Phytogenic/pharmacology ; Antineoplastic Agents, Phytogenic/chemistry ; Animals ; Mice ; Humans ; Molecular Docking Simulation ; A549 Cells ; Male
Περίληψη: The current study aims to determine: (i) the effect of isolated compounds (ICs) from E. neriifolia leaf via TLC and HPTLC on the lung cancer target protein through molecular docking; (ii) the cytotoxicity (MTT; 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide) and proapoptotic effect (DAPI; 4’-6-diamidino-2-phenylindole) of isolated linoleic acid (LA) in A549 cells; (iii) the in vivo anticancer potential of ENLE extract and LA against N-nitrosopiperidine (NPIP)-induced lung cancer in Swiss albino mice. Results revealed that LA was determined to be the better one among the studied ICs. This is due to its binding energy (-4.8 kcal/m and − 4.3 kcal/m), pharmacokinetic properties, and drug-likeliness. The LA decreased cell proliferation and viability above 400 µM after 24 and 48 h treatment. Apoptotic changes were revealed in treated adenocarcinoma (A549) cells with an IC50 dose of LA. The in-vivo analysis in Swiss albino mice (5–6 week old; 28–30 g) revealed that the administration of NPIP resulted in a reduction in body weight with a rise in serum levels of tumor markers (LDH, ADA, and 5’-ND), TP, and LPO. Metastasis markers (hexose, hexosamine, sialic acid, and uronic acid) with a concomitant reduction in the levels of enzymatic (SOD, CAT, and GPx), and non-enzymatic antioxidants (Vitamin E and Vitamin C) were also observed in response to NPIP administration. Moreover, high doses of ENLE, gefitinib (positive standard drug), and LA treatment significantly restored biochemical levels. Histological analyses showed restoration of normal architecture in the ENLE- and LA-treated groups. Immunohistology analyses revealed decreased p53 overexpression and normal CK7 levels compared with the NPIP group, indicating their protective effect. A high dose of ENLE after oral administration shows a remarkable decrease in tail length. The % tail DNA at a high dose of ENLE was determined to be 15.53 ± 0.11. Thus, the current study findings provide indications regarding the therapeutic potential of ENLE and LA against NPIP-induced lung cancer.
Competing Interests: Declarations. Conflict of Interests: The authors declare no competing interests.
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Contributed Indexing: Keywords: Euphorbia neriifolia; Apoptosis; Linoleic acid; Lung cancer; Molecular docking; NPIP
Substance Nomenclature: 0 (Plant Extracts)
0 (Tumor Suppressor Protein p53)
9KJL21T0QJ (Linoleic Acid)
0 (Antioxidants)
0 (Antineoplastic Agents, Phytogenic)
Entry Date(s): Date Created: 20260224 Date Completed: 20260627 Latest Revision: 20260627
Update Code: 20260627
DOI: 10.1007/s12013-026-02017-z
PMID: 41735757
Βάση Δεδομένων: MEDLINE
Περιγραφή
ISSN:1559-0283
DOI:10.1007/s12013-026-02017-z