Academic Journal
Gut-confined fullerene reprograms lactate metabolism to Rescue hypoxia-induced exercise intolerance.
| Τίτλος: | Gut-confined fullerene reprograms lactate metabolism to Rescue hypoxia-induced exercise intolerance. |
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| Συγγραφείς: | Chen S; Beijing National Laboratory for Molecular Sciences, Key Laboratory of Molecular Nanostructure and Nanotechnology, Institute of Chemistry, Chinese Academy of Sciences, Beijing 100190, China; University of Chinese Academy of Sciences, Beijing, 100049, China., Pan Y; Beijing National Laboratory for Molecular Sciences, Key Laboratory of Molecular Nanostructure and Nanotechnology, Institute of Chemistry, Chinese Academy of Sciences, Beijing 100190, China., Liu M; Beijing National Laboratory for Molecular Sciences, Key Laboratory of Molecular Nanostructure and Nanotechnology, Institute of Chemistry, Chinese Academy of Sciences, Beijing 100190, China; University of Chinese Academy of Sciences, Beijing, 100049, China., Liu C; Translational Medicine Research Center, Medical Innovation Research Division of Chinese PLA General Hospital, Beijing, 100853, China., Xu Y; Beijing National Laboratory for Molecular Sciences, Key Laboratory of Molecular Nanostructure and Nanotechnology, Institute of Chemistry, Chinese Academy of Sciences, Beijing 100190, China; University of Chinese Academy of Sciences, Beijing, 100049, China., Ma J; Beijing National Laboratory for Molecular Sciences, Key Laboratory of Molecular Nanostructure and Nanotechnology, Institute of Chemistry, Chinese Academy of Sciences, Beijing 100190, China; University of Chinese Academy of Sciences, Beijing, 100049, China., Li J; Beijing National Laboratory for Molecular Sciences, Key Laboratory of Molecular Nanostructure and Nanotechnology, Institute of Chemistry, Chinese Academy of Sciences, Beijing 100190, China., Wang X; Beijing National Laboratory for Molecular Sciences, Key Laboratory of Molecular Nanostructure and Nanotechnology, Institute of Chemistry, Chinese Academy of Sciences, Beijing 100190, China; University of Chinese Academy of Sciences, Beijing, 100049, China., Yang L; Beijing National Laboratory for Molecular Sciences, Key Laboratory of Molecular Nanostructure and Nanotechnology, Institute of Chemistry, Chinese Academy of Sciences, Beijing 100190, China; University of Chinese Academy of Sciences, Beijing, 100049, China., Wang Y; Beijing National Laboratory for Molecular Sciences, Key Laboratory of Molecular Nanostructure and Nanotechnology, Institute of Chemistry, Chinese Academy of Sciences, Beijing 100190, China; University of Chinese Academy of Sciences, Beijing, 100049, China., Li B; Beijing National Laboratory for Molecular Sciences, Key Laboratory of Molecular Nanostructure and Nanotechnology, Institute of Chemistry, Chinese Academy of Sciences, Beijing 100190, China., Wang Z; Beijing National Laboratory for Molecular Sciences, Key Laboratory of Molecular Nanostructure and Nanotechnology, Institute of Chemistry, Chinese Academy of Sciences, Beijing 100190, China., Zhang Y; Beijing FULLCAN Biotechnology Co., Beijing 100085, China., Shen H; Beijing FULLCAN Biotechnology Co., Beijing 100085, China., Wulan Q; College of Chemistry and Life Sciences, Chifeng University, Chifeng 024000, China., Li J; Beijing National Laboratory for Molecular Sciences, Key Laboratory of Molecular Nanostructure and Nanotechnology, Institute of Chemistry, Chinese Academy of Sciences, Beijing 100190, China. Electronic address: lijie24@iccas.ac.cn., Wang C; Beijing National Laboratory for Molecular Sciences, Key Laboratory of Molecular Nanostructure and Nanotechnology, Institute of Chemistry, Chinese Academy of Sciences, Beijing 100190, China; University of Chinese Academy of Sciences, Beijing, 100049, China. Electronic address: crwang@iccas.ac.cn., Bai C; Beijing National Laboratory for Molecular Sciences, Key Laboratory of Molecular Nanostructure and Nanotechnology, Institute of Chemistry, Chinese Academy of Sciences, Beijing 100190, China; University of Chinese Academy of Sciences, Beijing, 100049, China. Electronic address: clbai@cas.cn. |
| Πηγή: | Biomaterials [Biomaterials] 2026 Aug; Vol. 331, pp. 124075. Date of Electronic Publication: 2026 Feb 11. |
| Τύπος έκδοσης: | Journal Article |
| Γλώσσα: | English |
| Στοιχεία περιοδικού: | Publisher: Elsevier Science Country of Publication: Netherlands NLM ID: 8100316 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1878-5905 (Electronic) Linking ISSN: 01429612 NLM ISO Abbreviation: Biomaterials Subsets: MEDLINE |
| Imprint Name(s): | Publication: <1995-> : Amsterdam : Elsevier Science Original Publication: [Guilford, England] : IPC Science and Technology Press, 1980- |
| Ιατρικοί όροι (MeSH): | Fullerenes*/administration & dosage , Fullerenes*/pharmacology , Fullerenes*/therapeutic use , Hypoxia*/metabolism , Hypoxia*/complications , Lactic Acid*/metabolism , Exercise Tolerance*/drug effects , Gastrointestinal Tract*/metabolism , Gastrointestinal Tract*/drug effects, Hypoxia-Inducible Factor 1, alpha Subunit/metabolism ; Reactive Oxygen Species/metabolism ; Animals ; Mice, Inbred C57BL ; Mice |
| Περίληψη: | Chronic hypoxia-induced exercise intolerance, a hallmark of high-altitude deterioration (HADT), lacks safe long-term therapies. Here, we develop an orally administered fullerene (C (Copyright © 2026. Published by Elsevier Ltd.) |
| Competing Interests: | Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. |
| Contributed Indexing: | Keywords: Chronic mountain sickness; Exercise tolerance; Fullerene; Lactate metabolism |
| Substance Nomenclature: | 0 (Fullerenes) 33X04XA5AT (Lactic Acid) 0 (Hypoxia-Inducible Factor 1, alpha Subunit) 0 (Reactive Oxygen Species) |
| Entry Date(s): | Date Created: 20260224 Date Completed: 20260708 Latest Revision: 20260708 |
| Update Code: | 20260708 |
| DOI: | 10.1016/j.biomaterials.2026.124075 |
| PMID: | 41734653 |
| Βάση Δεδομένων: | MEDLINE |
| ISSN: | 1878-5905 |
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| DOI: | 10.1016/j.biomaterials.2026.124075 |