Late-adolescent weight categories and early kidney disease in young adulthood: a nationwide study of Arab and Jewish Israelis.

Λεπτομέρειες βιβλιογραφικής εγγραφής
Τίτλος: Late-adolescent weight categories and early kidney disease in young adulthood: a nationwide study of Arab and Jewish Israelis.
Συγγραφείς: Treister-Goltzman Y; Department of Family Medicine and Siaal Research Center for Family Practice and Primary Care, Faculty of Health Sciences, The Haim Doron Division of Community Health, Ben-Gurion University of the Negev, Beer-Sheva, Israel. yuliatr@walla.com.; Clalit Health Services, Tel Aviv, Israel. yuliatr@walla.com.
Πηγή: Pediatric nephrology (Berlin, Germany) [Pediatr Nephrol] 2026 Jul; Vol. 41 (7), pp. 2131-2143. Date of Electronic Publication: 2026 Feb 23.
Τύπος έκδοσης: Journal Article
Γλώσσα: English
Στοιχεία περιοδικού: Publisher: Springer International Country of Publication: Germany NLM ID: 8708728 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1432-198X (Electronic) Linking ISSN: 0931041X NLM ISO Abbreviation: Pediatr Nephrol Subsets: MEDLINE
Imprint Name(s): Publication: Berlin : Springer International
Original Publication: Berlin : Springer International, c1987-
Ιατρικοί όροι (MeSH): Arabs*/statistics & numerical data , Jews*/statistics & numerical data , Renal Insufficiency, Chronic*/epidemiology , Renal Insufficiency, Chronic*/ethnology , Renal Insufficiency, Chronic*/etiology , Pediatric Obesity*/complications , Pediatric Obesity*/epidemiology , Pediatric Obesity*/ethnology, Israel/epidemiology ; Humans ; Adolescent ; Retrospective Studies ; Male ; Young Adult ; Female ; Risk Factors ; Incidence ; Glomerular Filtration Rate ; Adult ; Body Weight
Περίληψη: Background: Previous reports have demonstrated that childhood obesity is associated with early chronic kidney disease. The aim of the study was to assess the relationship between weight categories in late adolescence and early chronic kidney disease (CKD) during young adulthood (age 30 years and younger) in individuals of Jewish and Arab ethnicity in Israel, on a nationwide level.
Methods: This retrospective cohort study included 102,902 adolescents aged 17-19 years - 47,892 of Jewish ethnicity and 53,492 of Arab ethnicity, born between 1988 and 1992 and insured by Clalit Health Services. Early CKD was defined when two urine albumin-to-creatinine ratio tests showed ≥ 30 mg/g within six months of an eGFR test ≥ 60 mL/min/1.73 m2.
Results: The incidence (95% CI) of early CKD was higher among adolescents of Arab than of Jewish ethnicity at 52.3 (46.7-58.4) and 34.6 (29.8-39.9) cases per 105 person-years, respectively. The risk for early CKD grew progressively, in adjusted to socio-economic variables models, increasing to HRs (95% CI) of 14.63 (8.86-24.15), and 9.75 (5.35-17.78) in the 'class 3 obesity' category among individuals of Arab and Jewish ethnicity, respectively. Sensitivity analyses among participants who had at least one microalbumin-creatinine ratio test and among participants who didn't develop hypertension and diabetes mellitus during follow-up showed similar patterns.
Conclusions: The findings emphasize the necessity of actions designed to decrease the prevalence of adolescent overweight and obesity, especially in the Arab ethnic minority in Israel. Adolescents with obesity should be monitored closely for signs of early CKD.
(© 2026. The Author(s).)
Competing Interests: Declarations. Ethics approval: The study was conducted in accordance with the guidelines of the Declaration of Helsinki. The Ethics Committee of Clalit Health Services approved the study (approval #0102–22-COM1, date: December 11, 2022) and exempted it from the requirement to obtain informed consent. Consent to participate: The Ethics Committee that approved the study also exempted it from the requirement to obtain informed consent. Consent to publish: Not applicable. Competing interests: The author has no relevant financial or non-financial interests to disclose.
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Contributed Indexing: Keywords: Cardio-vascular risk factors; Childhood obesity; Early chronic kidney disease; Ethnic differences
Entry Date(s): Date Created: 20260223 Date Completed: 20260708 Latest Revision: 20260709
Update Code: 20260709
PubMed Central ID: PMC13197338
DOI: 10.1007/s00467-026-07197-7
PMID: 41729282
Βάση Δεδομένων: MEDLINE
Περιγραφή
ISSN:1432-198X
DOI:10.1007/s00467-026-07197-7