Academic Journal
Genomic islands associated with the dissemination of multidrug resistance in clinically important pathogenic bacteria.
| Title: | Genomic islands associated with the dissemination of multidrug resistance in clinically important pathogenic bacteria. |
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| Authors: | Wang XQ; College of Life Sciences, Key Laboratory of Bio-Resource and Eco-Environment of Ministry of Education, Animal Disease Prevention and Green Development Key Laboratory of Sichuan Province, Sichuan University, Chengdu, People's Republic of China., Xu L; College of Life Sciences, Key Laboratory of Bio-Resource and Eco-Environment of Ministry of Education, Animal Disease Prevention and Green Development Key Laboratory of Sichuan Province, Sichuan University, Chengdu, People's Republic of China., Du MJ; College of Life Sciences, Key Laboratory of Bio-Resource and Eco-Environment of Ministry of Education, Animal Disease Prevention and Green Development Key Laboratory of Sichuan Province, Sichuan University, Chengdu, People's Republic of China., Wang HN; College of Life Sciences, Key Laboratory of Bio-Resource and Eco-Environment of Ministry of Education, Animal Disease Prevention and Green Development Key Laboratory of Sichuan Province, Sichuan University, Chengdu, People's Republic of China., Lei CW; College of Life Sciences, Key Laboratory of Bio-Resource and Eco-Environment of Ministry of Education, Animal Disease Prevention and Green Development Key Laboratory of Sichuan Province, Sichuan University, Chengdu, People's Republic of China. Electronic address: leichangwei@scu.edu.cn. |
| Source: | Journal of global antimicrobial resistance [J Glob Antimicrob Resist] 2026 May; Vol. 48, pp. 1-11. Date of Electronic Publication: 2026 Feb 20. |
| Publication Type: | Journal Article; Review |
| Language: | English |
| Journal Info: | Publisher: Published by Elsevier Ltd. on behalf of International Society of Chemotherapy for Infection and Cancer Country of Publication: Netherlands NLM ID: 101622459 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2213-7173 (Electronic) Linking ISSN: 22137165 NLM ISO Abbreviation: J Glob Antimicrob Resist Subsets: MEDLINE |
| Imprint Name(s): | Original Publication: Amsterdam : Published by Elsevier Ltd. on behalf of International Society of Chemotherapy for Infection and Cancer |
| MeSH Terms: | Drug Resistance, Multiple, Bacterial*/genetics , Bacteria*/genetics , Bacteria*/drug effects , Genomic Islands* , Gene Transfer, Horizontal*, Anti-Bacterial Agents/pharmacology ; Bacterial Infections/microbiology ; Humans |
| Abstract: | Objectives: To elucidate the role of genomic islands (GIs) as key vehicles of horizontal gene transfer in disseminating antibiotic-resistance genes (ARGs) across bacterial species and in fostering multidrug-resistant (MDR) strain emergence, and to provide a comprehensive overview of current knowledge. Methods: We integrated recent literature on mobile genomic islands (GIs), summarized their basic architecture and functional features, systematically catalogued the types/subtypes of resistance islands identified in major epidemic pathogens (Salmonella, Proteus mirabilis, Staphylococcus aureus, Acinetobacter baumannii, etc.), and delineated their horizontal transfer mechanisms. Results: (1) GIs can integrate into host chromosomes, excise under specific cues, and transfer to new recipients, thereby facilitating the spread of clinically important ARGs. (2) Diverse novel multidrug-resistant genomic islands have been characterized in the above pathogens. Conclusions: GIs are one of the key vehicles that facilitate the dissemination of ARGs and the evolution of bacterial multidrug resistance. A systematic understanding of their structure, transfer mechanisms and core functions offers a reference framework for future surveillance of multidrug-resistant genomic islands and for developing countermeasures against antimicrobial resistance. (Copyright © 2026 The Author(s). Published by Elsevier Ltd.. All rights reserved.) |
| Contributed Indexing: | Keywords: Dissemination; Genomic islands; Multidrug resistance; Pathogenic bacteria |
| Substance Nomenclature: | 0 (Anti-Bacterial Agents) |
| Entry Date(s): | Date Created: 20260222 Date Completed: 20260708 Latest Revision: 20260708 |
| Update Code: | 20260708 |
| DOI: | 10.1016/j.jgar.2026.02.007 |
| PMID: | 41724354 |
| Database: | MEDLINE |
| ISSN: | 2213-7173 |
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| DOI: | 10.1016/j.jgar.2026.02.007 |