Academic Journal
Redefining the entrance and exit of the Golgi apparatus.
| Τίτλος: | Redefining the entrance and exit of the Golgi apparatus. |
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| Συγγραφείς: | Nakano A; Institute of Integrated Research, Science Tokyo, Tokyo, Japan; RIKEN Center for Advanced Photonics, Saitama, Japan. Electronic address: nakano@riken.jp. |
| Πηγή: | Current opinion in cell biology [Curr Opin Cell Biol] 2026 Apr; Vol. 99, pp. 102622. Date of Electronic Publication: 2026 Feb 19. |
| Τύπος έκδοσης: | Journal Article; Review |
| Γλώσσα: | English |
| Στοιχεία περιοδικού: | Publisher: Elsevier Country of Publication: England NLM ID: 8913428 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1879-0410 (Electronic) Linking ISSN: 09550674 NLM ISO Abbreviation: Curr Opin Cell Biol Subsets: MEDLINE |
| Imprint Name(s): | Publication: London : Elsevier Original Publication: Philadelphia, PA, USA : Current Science, c1988- |
| Ιατρικοί όροι (MeSH): | Golgi Apparatus*/metabolism, Endoplasmic Reticulum/metabolism ; trans-Golgi Network/metabolism ; Animals ; Protein Transport ; Humans |
| Περίληψη: | The Golgi apparatus has a cis-to-trans polarity. The regions on both sides, the cis-Golgi network (CGN) and the trans-Golgi network (TGN), play important roles in controlling the entry and exit of cargo proteins. Regarding CGN, questions have persisted about whether it is commonly present in a variety of eukaryotes. I would summarize recent studies supporting the idea that CGN is a widely conserved compartment in animal, plant, and yeast cells. To clarify confusing terminology, I propose to use the term CGN consistently here. Morphologically, the structure of the Golgi and CGN as well as their spatial relationship with the endoplasmic reticulum exit sites (ERES) vary greatly among species but careful comparison reveals common fundamental characteristics of CGN. While CGN and TGN are sorting compartments regulating cargo traffic on the two faces of the Golgi, they are often mobile and can function independently of the main body Golgi. (Copyright © 2026 The Author(s). Published by Elsevier Ltd.. All rights reserved.) |
| Competing Interests: | Declaration of competing interest There are no competing interests to disclose. |
| Entry Date(s): | Date Created: 20260220 Date Completed: 20260708 Latest Revision: 20260708 |
| Update Code: | 20260708 |
| DOI: | 10.1016/j.ceb.2026.102622 |
| PMID: | 41719941 |
| Βάση Δεδομένων: | MEDLINE |
| ISSN: | 1879-0410 |
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| DOI: | 10.1016/j.ceb.2026.102622 |