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The Functions of the Golgin Family of Coiled-Coil Proteins.

Λεπτομέρειες βιβλιογραφικής εγγραφής
Τίτλος: The Functions of the Golgin Family of Coiled-Coil Proteins.
Συγγραφείς: Arab M; School of Biological Sciences, Faculty of Biology, Medicine and Health, University of Manchester, Manchester, UK., Lowe M; School of Biological Sciences, Faculty of Biology, Medicine and Health, University of Manchester, Manchester, UK. martin.p.lowe@manchester.ac.uk.
Πηγή: Sub-cellular biochemistry [Subcell Biochem] 2026; Vol. 111, pp. 71-92.
Τύπος έκδοσης: Journal Article; Review
Γλώσσα: English
Στοιχεία περιοδικού: Publisher: Springer Country of Publication: United States NLM ID: 0316571 Publication Model: Print Cited Medium: Print ISSN: 0306-0225 (Print) Linking ISSN: 03060225 NLM ISO Abbreviation: Subcell Biochem Subsets: MEDLINE
Imprint Name(s): Publication: <2006- > : New York : Springer
Original Publication: London, New York, Plenum Press.
Ιατρικοί όροι (MeSH): Golgi Apparatus*/metabolism , Membrane Proteins*/metabolism , Membrane Proteins*/genetics, Microtubules/metabolism ; Humans ; Animals ; Golgi Matrix Proteins
Περίληψη: The golgins are a family of ubiquitously expressed and evolutionary conserved Golgi-localised coiled-coil proteins. The golgins are particularly important for vesicle trafficking and structural organisation of the Golgi apparatus. The golgins mediate tethering, or long-range capture, of transport vesicles to Golgi membranes, a key step in vesicle traffic that ensures the specificity of vesicle transport at the Golgi. Following tethering, the golgins associate with other factors to ensure that vesicles undergo the transition to membrane fusion mediated by SNARE proteins. The golgins also contribute to the structural organisation of the Golgi apparatus, particularly in Golgi ribbon formation. This is achieved in several ways, which includes linking the Golgi membranes to the microtubule cytoskeleton, controlling the activity of cytoskeletal regulators and physically linking Golgi elements into the ribbon. Golgin-dependent interactions with the microtubule cytoskeleton also contribute to cell polarity, migration and division. In addition to regulating Golgi function and organisation, the golgins scaffold various factors to control the activity of these factors in a range of cellular processes which includes signaling, autophagy, spindle assembly and cell fate determination. In this book chapter we discuss current understanding of the golgins and their functional roles in cells.
(© 2026. The Editor(s) (if applicable) and The Author(s), under exclusive license to Springer Nature Switzerland AG.)
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Contributed Indexing: Keywords: Golgi ribbon; Golgi structure; Golgin; Membrane traffic; Rab GTPase; Vesicle tethering
Substance Nomenclature: 0 (Membrane Proteins)
0 (Golgi Matrix Proteins)
Entry Date(s): Date Created: 20260220 Date Completed: 20260708 Latest Revision: 20260708
Update Code: 20260708
DOI: 10.1007/978-3-032-16833-7_4
PMID: 41718973
Βάση Δεδομένων: MEDLINE
Περιγραφή
ISSN:0306-0225
DOI:10.1007/978-3-032-16833-7_4