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Characterizing behavioral effects of early-life stress in an animal model of auditory processing.

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Τίτλος: Characterizing behavioral effects of early-life stress in an animal model of auditory processing.
Συγγραφείς: Hardy KA; Hearing Research Group, Department of Biomedical Sciences, Northeast Ohio Medical University, Rootstown, OH, USA; Biomedical Sciences Program, Kent State University, Kent, OH, USA. Electronic address: KAHardy09@gmail.com., Rybolt S; Hearing Research Group, Department of Biomedical Sciences, Northeast Ohio Medical University, Rootstown, OH, USA. Electronic address: srybolt@neomed.edu., Patel B; Hearing Research Group, Department of Biomedical Sciences, Northeast Ohio Medical University, Rootstown, OH, USA. Electronic address: bpatel13@neomed.edu., Dye R; Hearing Research Group, Department of Biomedical Sciences, Northeast Ohio Medical University, Rootstown, OH, USA. Electronic address: rdye@neomed.edu., Rosen MJ; Hearing Research Group, Department of Biomedical Sciences, Northeast Ohio Medical University, Rootstown, OH, USA; University Hospitals | NEOMED Hearing Research Center, Northeast Ohio Medical University, Rootstown, OH, USA; Brain Health Research Institute, Kent State University, Kent, OH, USA. Electronic address: mrosen@neomed.edu.
Πηγή: Physiology & behavior [Physiol Behav] 2026 May 01; Vol. 308, pp. 115278. Date of Electronic Publication: 2026 Feb 17.
Τύπος έκδοσης: Journal Article; Research Support, N.I.H., Extramural
Γλώσσα: English
Στοιχεία περιοδικού: Publisher: Elsevier Science Country of Publication: United States NLM ID: 0151504 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-507X (Electronic) Linking ISSN: 00319384 NLM ISO Abbreviation: Physiol Behav Subsets: MEDLINE
Imprint Name(s): Publication: New York NY : Elsevier Science
Original Publication: Oxford, Eng., Long Island City, Pergamon Press.
Ιατρικοί όροι (MeSH): Stress, Psychological*/physiopathology , Stress, Psychological*/psychology , Auditory Perception*/physiology, Auditory Cortex/growth & development ; Animals ; Gerbillinae ; Male ; Female ; Disease Models, Animal ; Acoustic Stimulation ; Conditioning, Operant
Περίληψη: Animal models provide significant insight into the development of typical and disordered sensory processing. Such models have been established to take advantage of physical and behavioral characteristics of specific species. For example, the Mongolian gerbil is a well-established model for auditory processing, with a hearing range similar in frequency to that of humans and an easily accessible cochlea. Recently, early-life stress (ELS) has been shown to affect sensory processing in auditory, visual, and somatosensory neural regions. To understand the functional impact of ELS, it is necessary to evaluate the susceptibility of sensory perceptual abilities to this early perturbation. Yet measuring sensory perception - e.g., using operant conditioning - often concurrently involves animal behavioral elements such as attention, memory, learning, and emotion. All of these elements are well-known to be impacted by ELS, and may affect behavioral measurements in ways that could be misconstrued as sensory deficits. Thus, it is critical to characterize which behavioral elements are affected by ELS in any sensory model. Here we induced ELS during a developmental time window for maturation of the auditory cortex in Mongolian gerbils. We conducted behavioral measures in juveniles, a developmental age when ELS is known to impair the auditory pathway. ELS had no effect on overall activity but reduced anxiety-related behavior, impaired recognition memory, and improved spatial memory, with some sex-specific effects. These effects may influence the ability of gerbils to learn and retain operant training, particularly if anxiety-provoking reinforcement is used.
(Copyright © 2026 The Author(s). Published by Elsevier Inc. All rights reserved.)
Competing Interests: Declaration of competing interest The authors declare no competing interests.
Σχόλια: Update of: bioRxiv. 2024 Dec 04:2024.12.03.626725. doi: 10.1101/2024.12.03.626725.. (PMID: 39677688)
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Grant Information: R01 DC013314 United States DC NIDCD NIH HHS
Contributed Indexing: Keywords: Adolescence; Adversity; Anxiety; Auditory; Cognition; Development; Early-life stress; Memory; Mongolian gerbil
Entry Date(s): Date Created: 20260219 Date Completed: 20260708 Latest Revision: 20260813
Update Code: 20260813
PubMed Central ID: PMC13367662
DOI: 10.1016/j.physbeh.2026.115278
PMID: 41713832
Βάση Δεδομένων: MEDLINE
Περιγραφή
ISSN:1873-507X
DOI:10.1016/j.physbeh.2026.115278