Academic Journal
Neochlorogenic acid targets caseinolytic protease P to Suppress MRSA pathogenicity and Unlocks a novel therapeutic avenue for osteomyelitis.
| Τίτλος: | Neochlorogenic acid targets caseinolytic protease P to Suppress MRSA pathogenicity and Unlocks a novel therapeutic avenue for osteomyelitis. |
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| Συγγραφείς: | Wang Y; Yanbian University Medical College, Yanji 133002, PR China., Lin X; The Affiliated Hospital of Yanbian University, Yanji 133000, PR China., Du Y; Jilin Key Laboratory for Immune and Targeting Research on Common Allergic Diseases, Yanbian University, Yanji 133002, PR China., Jiang H; Yanbian University Medical College, Yanji 133002, PR China., Xu P; Yanbian University Medical College, Yanji 133002, PR China., Sun Y; Changchun University of Chinese Medicine, Changchun 130117, PR China., Liu X; Changchun University of Chinese Medicine, Changchun 130117, PR China., Gao H; Changchun University of Chinese Medicine, Changchun 130117, PR China., Gao Y; Changchun University of Chinese Medicine, Changchun 130117, PR China., Wang B; Changchun University of Chinese Medicine, Changchun 130117, PR China., Li L; Jilin Key Laboratory for Immune and Targeting Research on Common Allergic Diseases, Yanbian University, Yanji 133002, PR China; Department of Anatomy, Histology and Embryology, Yanbian University Medical College, Yanji 133002, PR China. Electronic address: lclee@ybu.edu.cn., Zhou X; The Affiliated Hospital of Yanbian University, Yanji 133000, PR China. Electronic address: xczhou@ybu.edu.cn. |
| Πηγή: | Biochemical pharmacology [Biochem Pharmacol] 2026 Jun; Vol. 248, pp. 117811. Date of Electronic Publication: 2026 Feb 13. |
| Τύπος έκδοσης: | Journal Article |
| Γλώσσα: | English |
| Στοιχεία περιοδικού: | Publisher: Elsevier Science Country of Publication: England NLM ID: 0101032 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-2968 (Electronic) Linking ISSN: 00062952 NLM ISO Abbreviation: Biochem Pharmacol Subsets: MEDLINE |
| Imprint Name(s): | Publication: Oxford : Elsevier Science Original Publication: Oxford, New York [etc.] Paragamon Press. |
| Ιατρικοί όροι (MeSH): | Methicillin-Resistant Staphylococcus aureus*/drug effects , Methicillin-Resistant Staphylococcus aureus*/pathogenicity , Methicillin-Resistant Staphylococcus aureus*/enzymology , Osteomyelitis*/drug therapy , Osteomyelitis*/microbiology , Anti-Bacterial Agents*/pharmacology , Anti-Bacterial Agents*/therapeutic use , Endopeptidase Clp*/antagonists & inhibitors , Endopeptidase Clp*/metabolism, Staphylococcal Infections/drug therapy ; Staphylococcal Infections/microbiology ; Virulence/drug effects ; Virulence/physiology ; Animals ; Rats ; Mice ; Rats, Sprague-Dawley |
| Περίληψη: | Osteomyelitis is a complex and challenging infectious disease in orthopedics that is caused predominantly by methicillin-resistant Staphylococcus aureus (MRSA). The development of novel anti-infective strategies to overcome antibiotic resistance is urgently needed. Caseinolytic protease (ClpP), a key regulator of MRSA virulence, represents a promising target. Using fluorescence resonance energy transfer screening, this study identified neochlorogenic acid (NCA) as an effective ClpP inhibitor, with an IC (Copyright © 2026. Published by Elsevier Inc.) |
| Competing Interests: | Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. |
| Contributed Indexing: | Keywords: Antivirulence; Caseinolytic protease; Methicillin-resistantStaphylococcus aureus; Neochlorogenic acid; Osteomyelitis |
| Substance Nomenclature: | 0 (Anti-Bacterial Agents) EC 3.4.21.92 (Endopeptidase Clp) |
| Entry Date(s): | Date Created: 20260215 Date Completed: 20260708 Latest Revision: 20260708 |
| Update Code: | 20260708 |
| DOI: | 10.1016/j.bcp.2026.117811 |
| PMID: | 41692351 |
| Βάση Δεδομένων: | MEDLINE |
| ISSN: | 1873-2968 |
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| DOI: | 10.1016/j.bcp.2026.117811 |