Academic Journal
Limited discriminatory value of RAMRIS findings between RA and hand osteoarthritis: a cross-sectional MRI study.
| Τίτλος: | Limited discriminatory value of RAMRIS findings between RA and hand osteoarthritis: a cross-sectional MRI study. |
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| Συγγραφείς: | Sewerin P; Ruhr-Universität Bochum, Bochum, Germany. Philipp.Sewerin@rub.de.; Ruhr-Universität Bochum, Rheumazentrum Ruhrgebiet, Claudiusstrasse 45, 44649, Herne, Germany. Philipp.Sewerin@rub.de., Kiefer D; Ruhr-Universität Bochum, Bochum, Germany.; Ruhr-Universität Bochum, Rheumazentrum Ruhrgebiet, Claudiusstrasse 45, 44649, Herne, Germany., Arcq JM; Ruhr-Universität Bochum, Bochum, Germany.; Ruhr-Universität Bochum, Rheumazentrum Ruhrgebiet, Claudiusstrasse 45, 44649, Herne, Germany., Tsiami S; Ruhr-Universität Bochum, Bochum, Germany.; Ruhr-Universität Bochum, Rheumazentrum Ruhrgebiet, Claudiusstrasse 45, 44649, Herne, Germany., Mucke J; Ruhr-Universität Bochum, Bochum, Germany.; Ruhr-Universität Bochum, Rheumazentrum Ruhrgebiet, Claudiusstrasse 45, 44649, Herne, Germany., Kernder A; Ruhr-Universität Bochum, Bochum, Germany.; Ruhr-Universität Bochum, Rheumazentrum Ruhrgebiet, Claudiusstrasse 45, 44649, Herne, Germany., Kiltz U; Ruhr-Universität Bochum, Bochum, Germany.; Ruhr-Universität Bochum, Rheumazentrum Ruhrgebiet, Claudiusstrasse 45, 44649, Herne, Germany., Baraliakos X; Ruhr-Universität Bochum, Bochum, Germany. baraliakos@me.com.; Ruhr-Universität Bochum, Rheumazentrum Ruhrgebiet, Claudiusstrasse 45, 44649, Herne, Germany. baraliakos@me.com. |
| Πηγή: | Rheumatology international [Rheumatol Int] 2026 Feb 14; Vol. 46 (3), pp. 48. Date of Electronic Publication: 2026 Feb 14. |
| Τύπος έκδοσης: | Journal Article |
| Γλώσσα: | English |
| Στοιχεία περιοδικού: | Publisher: Springer International Country of Publication: Germany NLM ID: 8206885 Publication Model: Electronic Cited Medium: Internet ISSN: 1437-160X (Electronic) Linking ISSN: 01728172 NLM ISO Abbreviation: Rheumatol Int Subsets: MEDLINE |
| Imprint Name(s): | Original Publication: [Berlin ; New York, NY] : Springer International, c1981- |
| Ιατρικοί όροι (MeSH): | Arthritis, Rheumatoid*/diagnostic imaging , Osteoarthritis*/diagnostic imaging , Hand Joints*/diagnostic imaging , Hand Joints*/pathology , Magnetic Resonance Imaging*, Synovitis/diagnostic imaging ; Tenosynovitis/diagnostic imaging ; Edema/diagnostic imaging ; Humans ; Female ; Male ; Middle Aged ; Cross-Sectional Studies ; Retrospective Studies ; Aged ; Severity of Illness Index ; Diagnosis, Differential ; Predictive Value of Tests |
| Περίληψη: | To evaluate the capacity of the RA MRI Score (RAMRIS) in distinguishing rheumatoid arthritis (RA) and hand osteoarthritis (HOA). Patients with RA and HOA were retrospectively matched in pairs. Inflammatory and degenerative changes in MRI scans of the hands were quantified and compared using RAMRIS, focusing on bone marrow edema (BME), erosion, synovitis, and tenosynovitis. CRP, ESR, and autoantibodies (RF and ACPA) and clinical scores (DAS-28, FFbH, and pain level), smoking status, and medication use were assessed additionally. Overall, 100 RA and 100 HOA patients with confirmed diagnosis were included. Age, pain severity, and functional impairment did not differ between groups. RAMRIS revealed significantly higher synovitis subscores in RA compared to HOA (p<0.001), while no significant differences were found for BME (p = 0.076), erosion (p = 0.366), or tenosynovitis (p = 0.129). Higher RAMRIS scores were observed at the level of individual joints in RA. The mean erosion-subscore was found to be higher in RA males than in RA females, though this was not observed in all joints. In HOA, men exhibited a mean erosion score that was higher than that of women. Smoking status had limited association with RAMRIS findings, but RA non-smokers exhibited greater inflammatory burden than HOA non-smokers in multiple joints. RA exhibited significantly higher synovitis subscores, indicative of active inflammation and leading to overall higher RAMRIS scores, compared to HOA. However, HOA demonstrated high RAMRIS scores for synovitis, tenosynovitis, erosions, and BME. MRI may assist in distinguishing RA from HOA; however, its interpretation must be integrated into the clinical context. |
| Competing Interests: | Declarationss. Conflict of interest: The authors declare no conflict of interest. Ethical approval and informed consent: The study was conducted in accordance with the Declaration of Helsinki and participants provided informed consent in accordance. The study was approved by the institutional ethics committee of the Ruhr-University of Bochum (approval number 2016-379-f-S). |
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| Contributed Indexing: | Keywords: Imaging-MRI; OA; Rheumatoid arthritis (RA) |
| Entry Date(s): | Date Created: 20260214 Date Completed: 20260627 Latest Revision: 20260920 |
| Update Code: | 20260920 |
| PubMed Central ID: | PMC12906534 |
| DOI: | 10.1007/s00296-026-06085-5 |
| PMID: | 41689640 |
| Βάση Δεδομένων: | MEDLINE |
| ISSN: | 1437-160X |
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| DOI: | 10.1007/s00296-026-06085-5 |