Academic Journal
Androgen receptor expression and immune characteristics of HER2-low metastatic triple-negative breast cancer.
| Τίτλος: | Androgen receptor expression and immune characteristics of HER2-low metastatic triple-negative breast cancer. |
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| Συγγραφείς: | Tarantino P; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA. Paolo_Tarantino@dfci.harvard.edu.; Breast Oncology Program, Dana-Farber Brigham Cancer Center, Boston, MA, USA. Paolo_Tarantino@dfci.harvard.edu.; Harvard Medical School, Boston, MA, USA. Paolo_Tarantino@dfci.harvard.edu., Cha J; Harvard Medical School, Boston, MA, USA., Binboga Kurt B; Department of Pathology, Brigham and Women's Hospital, Boston, MA, USA., Chu X; Department of Data Science, Dana-Farber Cancer Institute, Boston, MA, USA., Jovanović B; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA.; Breast Oncology Program, Dana-Farber Brigham Cancer Center, Boston, MA, USA.; Harvard Medical School, Boston, MA, USA.; Loxo@Lilly, Indianapolis, IN, USA., Zhou A; Harvard Medical School, Boston, MA, USA., Hughes M; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA.; Breast Oncology Program, Dana-Farber Brigham Cancer Center, Boston, MA, USA., Russo D; Department of Data Science, Dana-Farber Cancer Institute, Boston, MA, USA., DiLullo M; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA., Wrabel E; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA., Jeselsohn R; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA.; Breast Oncology Program, Dana-Farber Brigham Cancer Center, Boston, MA, USA.; Harvard Medical School, Boston, MA, USA., Lin NU; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA.; Breast Oncology Program, Dana-Farber Brigham Cancer Center, Boston, MA, USA.; Harvard Medical School, Boston, MA, USA., Carter J; Breast Oncology Program, Dana-Farber Brigham Cancer Center, Boston, MA, USA., Chen YS; Breast Oncology Program, Dana-Farber Brigham Cancer Center, Boston, MA, USA., Li T; Department of Data Science, Dana-Farber Cancer Institute, Boston, MA, USA., Tayob N; Harvard Medical School, Boston, MA, USA.; Department of Data Science, Dana-Farber Cancer Institute, Boston, MA, USA., Mittendorf EA; Breast Oncology Program, Dana-Farber Brigham Cancer Center, Boston, MA, USA.; Harvard Medical School, Boston, MA, USA.; Division of Breast Surgery, Department of Surgery, Brigham and Women's Hospital, Boston, MA, USA., Schnitt SJ; Breast Oncology Program, Dana-Farber Brigham Cancer Center, Boston, MA, USA.; Department of Pathology, Brigham and Women's Hospital, Boston, MA, USA., Goel S; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA.; Breast Oncology Program, Dana-Farber Brigham Cancer Center, Boston, MA, USA., Tolaney SM; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA.; Breast Oncology Program, Dana-Farber Brigham Cancer Center, Boston, MA, USA.; Harvard Medical School, Boston, MA, USA. |
| Πηγή: | NPJ breast cancer [NPJ Breast Cancer] 2026 Feb 13; Vol. 12 (1). Date of Electronic Publication: 2026 Feb 13. |
| Τύπος έκδοσης: | Journal Article |
| Γλώσσα: | English |
| Στοιχεία περιοδικού: | Publisher: Breast Cancer Research Foundation Country of Publication: United States NLM ID: 101674891 Publication Model: Electronic Cited Medium: Print ISSN: 2374-4677 (Print) Linking ISSN: 23744677 NLM ISO Abbreviation: NPJ Breast Cancer Subsets: PubMed not MEDLINE |
| Imprint Name(s): | Original Publication: New York, NY : Breast Cancer Research Foundation : Nature Publishing Group, [2015]- |
| Περίληψη: | HER2-low expression is associated with hormone receptor (HR) expression in HR-positive breast cancer. We aimed to evaluate its association with androgen receptor (AR) among 196 patients with metastatic triple-negative breast cancer (mTNBC). Central determination of AR showed significant enrichment in HER2-low compared with HER2-0 mTNBC (mean: 33.7% vs. 21.4%, p = 0.038), whereas no significant immunological differences were observed. HER2-low/AR-positive patients trended towards longer overall survival, highlighting the potential relevance of these biomarkers. (© 2026. The Author(s).) |
| Competing Interests: | Competing interests: P.T. reports consulting fees from AstraZeneca, Daiichi Sankyo, Gilead, Genentech/Roche, Novartis, Menarini/Stemline, and Eli Lilly. NUL reports institutional research support from Genentech, Pfizer, Merck, Seattle Genetics, Zion Pharmaceuticals, Olema Pharmaceuticals, and AstraZeneca; consulting honoraria from Seattle Genetics, Daiichi Sankyo, AstraZeneca, Olema Pharmaceuticals, Stemline/Menarini, Artera Inc., Eisai, and Shorla Oncology; royalties from Up to date (book); and travel support from Olema Pharmaceuticals, AstraZeneca, and Daiichi Sankyo. SMT reports consulting or advisory roles for Novartis, Pfizer/SeaGen, Merck, Eli Lilly, AstraZeneca, Genentech/Roche, Eisai, Bristol Myers Squibb/Systimmune, Daiichi Sankyo, Gilead, Blueprint Medicines, Reveal Genomics, Sumitovant Biopharma, Artios Pharma, Menarini/Stemline, Aadi Bio, Bayer, Jazz Pharmaceuticals, Natera, Tango Therapeutics, eFFECTOR, Hengrui USA, Cullinan Oncology, Circle Pharma, Arvinas, BioNTech, Johnson&Johnson/Ambrx, Launch Therapeutics, Zuellig Pharma, Bicycle Therapeutics, BeiGene Therapeutics, Mersana, Summit Therapeutics, Avenzo Therapeutics, Aktis Oncology, Celcuity, Boehringer Ingelheim, Samsung Bioepis, Olema Pharmaceuticals, Tempus, and Boundless Bio; institutional research funding from Genentech/Roche, Merck, Exelixis, Pfizer, Lilly, Novartis, Bristol Myers Squibb, AstraZeneca, Gilead, NanoString Technologies, Seattle Genetics, OncoPep, Daiichi Sankyo, Menarini/Stemline, Jazz Pharmaceuticals, and Olema Pharmaceuticals; and travel support from Eli Lilly, Gilead, Jazz Pharmaceuticals, Pfizer, Arvinas, and Roche. |
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| Entry Date(s): | Date Created: 20260213 Date Completed: 20260325 Latest Revision: 20260813 |
| Update Code: | 20260813 |
| PubMed Central ID: | PMC13013833 |
| DOI: | 10.1038/s41523-026-00913-4 |
| PMID: | 41688468 |
| Βάση Δεδομένων: | MEDLINE |
| ISSN: | 2374-4677 |
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| DOI: | 10.1038/s41523-026-00913-4 |