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Sources, characterization approaches, artificial synthesis, and biological significance of 4,4-dimethylsterols: a review.

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Τίτλος: Sources, characterization approaches, artificial synthesis, and biological significance of 4,4-dimethylsterols: a review.
Συγγραφείς: Ahmad MI; College of Biosystems Engineering and Food Science, Zhejiang Key Laboratory for Agro-Food Processing, Zhejiang University, Hangzhou, China., Zhou S; Wilmar (Shanghai) Biotechnology Research & Development Center Co. Ltd, Shanghai, China., Farooq S; College of Biosystems Engineering and Food Science, Zhejiang Key Laboratory for Agro-Food Processing, Zhejiang University, Hangzhou, China., Ali U; College of Biosystems Engineering and Food Science, Zhejiang Key Laboratory for Agro-Food Processing, Zhejiang University, Hangzhou, China., Li T; College of Biosystems Engineering and Food Science, Zhejiang Key Laboratory for Agro-Food Processing, Zhejiang University, Hangzhou, China., Zhang H; College of Biosystems Engineering and Food Science, Zhejiang Key Laboratory for Agro-Food Processing, Zhejiang University, Hangzhou, China.
Πηγή: Journal of the science of food and agriculture [J Sci Food Agric] 2026 Aug 30; Vol. 106 (11), pp. 6287-6298. Date of Electronic Publication: 2026 Feb 11.
Τύπος έκδοσης: Journal Article; Review
Γλώσσα: English
Στοιχεία περιοδικού: Publisher: John Wiley & Sons Country of Publication: England NLM ID: 0376334 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1097-0010 (Electronic) Linking ISSN: 00225142 NLM ISO Abbreviation: J Sci Food Agric Subsets: MEDLINE
Imprint Name(s): Publication: <2005-> : Chichester, West Sussex : John Wiley & Sons
Original Publication: London, Society of Chemical Industry.
Ιατρικοί όροι (MeSH): Phytosterols*/chemistry , Phytosterols*/chemical synthesis , Phytosterols*/pharmacology, Anti-Inflammatory Agents/chemistry ; Anti-Inflammatory Agents/chemical synthesis ; Anti-Inflammatory Agents/pharmacology ; Humans ; Animals ; Molecular Structure
Περίληψη: 4,4-Dimethylsterols constitute a unique class of phytosterols - naturally occurring compounds that have gained significant attention due to their potential health benefits and wide-ranging biological activities. This review explores the diverse sources, chemical structure, synthetic approaches, and identification methods, focusing on the unique properties of 4,4-dimethylsterols that distinguish them within the sterol family. Comparative evaluation of analytical techniques such as solid-phase extraction, thin-layer chromatography, and gas chromatography-mass spectrometry are evaluated for their effectiveness in identifying and quantifying these compounds, which play a crucial role in verifying oil authenticity. Synthetic approaches, such as chemical synthesis and enzymatic transformation are also discussed in the context of 4,4-dimethylsterol production. Beyond methodology, the review examines the emerging trends linking 4,4-dimethylsterols to anti-inflammatory, anti-Alzheimer's, and anti-Parkinsonian properties. Finally, this review addresses prevailing challenges surrounding 4,4-dimethylsterols, including bioavailability, stability, and safety profiles, while offering a glimpse into the future of 4,4-dimethylsterol research. This review produces current knowledge and spotlights overlooked functional attributes, positioning 4,4-dimethylsterols as promising candidates for nutraceutical and therapeutic applications. © 2026 Society of Chemical Industry.
(© 2026 Society of Chemical Industry.)
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Grant Information: Talent Introduction Program of Postdoctoral International Exchange Program to Excellent International Young Researchers by the Office of China Postdoc Council (OCPC); 2023C02044 Pioneer" and "Leading Goose" R&D Program of Zhejiang Province; Zhejiang University
Contributed Indexing: Keywords: 4,4‐dimethylsterols; chemical synthesis; enzymatic synthesis; health benefits; phytosterols
Substance Nomenclature: 0 (Phytosterols)
0 (Anti-Inflammatory Agents)
Entry Date(s): Date Created: 20260212 Date Completed: 20260708 Latest Revision: 20260708
Update Code: 20260708
DOI: 10.1002/jsfa.70517
PMID: 41674113
Βάση Δεδομένων: MEDLINE
Περιγραφή
ISSN:1097-0010
DOI:10.1002/jsfa.70517