Academic Journal
Regulation of chemicals demands assessment of risks rather than identification of hazards only.
| Τίτλος: | Regulation of chemicals demands assessment of risks rather than identification of hazards only. |
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| Συγγραφείς: | Marx-Stoelting P; German Federal Institute for Risk Assessment (BfR), Berlin, Germany. philip.marx-stoelting@bfr.bund.de., Ritz V; German Federal Institute for Risk Assessment (BfR), Berlin, Germany., Herzler M; German Federal Institute for Risk Assessment (BfR), Berlin, Germany., Kneuer C; German Federal Institute for Risk Assessment (BfR), Berlin, Germany., Aiello-Holden K; German Federal Institute for Risk Assessment (BfR), Berlin, Germany., Brescia S; Health and Safety Executive (HSE), Chemicals Regulation Division (CRD), Merseyside, UK., Escher SE; Fraunhofer ITEM, Hannover, Germany., Feustel S; German Federal Institute for Risk Assessment (BfR), Berlin, Germany., Fritsche E; Swiss Centre for Applied Human Toxicology (SCAHT), University of Basel, Basel, Switzerland., Gebel J; University Hospital Bonn, Institute for Hygiene and Public Health, Bonn, Germany., Kenny EF; German Federal Institute for Risk Assessment (BfR), Berlin, Germany., Landsiedel R; German Society for Toxicology (GT), Mainz, Germany.; Institute for Pharmacology and Toxicology, Freie Universität Berlin, Berlin, Germany., Sanders P; French National Agency for Food, Environmental and Occupational Health and Safety, Paris, France., Schwarz M; Department for Experimental and Clinical Pharmacology and Pharmacogenomics, Eberhard Karls University, Tübingen, Germany., Streitz M; Friedrich-Löffler-Institute, Riems, Germany., Testai E; Formerly Instituto Superiore di Sanità, Environment and Health Dept., Rome, Italy., van Ravenzwaay B; University of Wageningen, Wageningen, The Netherlands., Waetjen W; Institute for Agriculture and Food Science, Martin-Luther-Universität Halle-Wittenberg, Halle, Germany., Wend K; German Federal Ministry for Agriculture, Food and Rural Environments, Berlin, Germany., Wilks M; Department of Pharmaceutical Sciences, University of Basel, Basel, Switzerland., Luch A; German Federal Institute for Risk Assessment (BfR), Berlin, Germany., Tralau T; German Federal Institute for Risk Assessment (BfR), Berlin, Germany., Hensel A; German Federal Institute for Risk Assessment (BfR), Berlin, Germany. |
| Πηγή: | Archives of toxicology [Arch Toxicol] 2026 Mar; Vol. 100 (3), pp. 1181-1185. Date of Electronic Publication: 2026 Feb 07. |
| Τύπος έκδοσης: | Journal Article; Editorial |
| Γλώσσα: | English |
| Στοιχεία περιοδικού: | Publisher: Springer-Verlag Country of Publication: Germany NLM ID: 0417615 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1432-0738 (Electronic) Linking ISSN: 03405761 NLM ISO Abbreviation: Arch Toxicol Subsets: MEDLINE |
| Imprint Name(s): | Original Publication: Berlin, New York, Springer-Verlag. |
| Ιατρικοί όροι (MeSH): | Hazardous Substances*/toxicity , Government Regulation*, Risk Assessment/methods ; Environmental Exposure/adverse effects ; Humans ; Animals ; European Union |
| Περίληψη: | This position paper was collaboratively written during the international expert symposium "EU Chemicals Assessment - Risk- or Hazard-based?" that was organised by the German Federal Institute for Risk Assessment (BfR) in Berlin on November 27th and 28th 2025. Twenty experts from several institutions and European countries considered the scientific merits of both hazard-based and risk-based approaches to chemical safety assessment. While hazard information is essential, it does not reflect real-world exposure conditions that determine the likelihood of harm. On balance, we support a risk-based approach because it enables more proportionate, transparent and scientifically grounded regulatory decisions. (© 2026. The Author(s).) |
| Competing Interests: | Declarations. Conflict of interest: The authors declare that they are or have been involved in different roles in the hazard- and risk assessment of chemicals. Ellen Fritsche is shareholder of the DNTOX GmbH, a contract research organization offering (developmental) neurotoxicity testing. The authors declare that they do not have further conflicts of interest. |
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| Substance Nomenclature: | 0 (Hazardous Substances) |
| Entry Date(s): | Date Created: 20260207 Date Completed: 20260707 Latest Revision: 20260707 |
| Update Code: | 20260707 |
| PubMed Central ID: | PMC12967599 |
| DOI: | 10.1007/s00204-026-04307-0 |
| PMID: | 41654646 |
| Βάση Δεδομένων: | MEDLINE |
| ISSN: | 1432-0738 |
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| DOI: | 10.1007/s00204-026-04307-0 |