Academic Journal
Changes in Spinal Neural Circuit Plasticity in a Rat Sciatic Nerve Transection Model.
| Τίτλος: | Changes in Spinal Neural Circuit Plasticity in a Rat Sciatic Nerve Transection Model. |
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| Συγγραφείς: | Konishi K; Department of Orthopaedic Surgery, Osaka University Graduate School of Medicine, Suita, Osaka, Japan., Iwahashi T; Department of Orthopaedic Surgery, Osaka University Graduate School of Medicine, Suita, Osaka, Japan., Kasuya T; Department of Orthopaedic Surgery, Osaka University Graduate School of Medicine, Suita, Osaka, Japan., Shimada T; Department of Orthopaedic Surgery, Osaka University Graduate School of Medicine, Suita, Osaka, Japan., Yoshimura Y; Department of Orthopaedic Surgery, Osaka University Graduate School of Medicine, Suita, Osaka, Japan., Kamata A; Department of Orthopaedic Surgery, Osaka University Graduate School of Medicine, Suita, Osaka, Japan., Konishi M; Department of Orthopaedic Surgery, Osaka University Graduate School of Medicine, Suita, Osaka, Japan., Wang M; Department of Sports Medical Science, Osaka University Graduate School of Medicine, Suita, Osaka, Japan., Kazui A; Department of Orthopaedic Surgery, Osaka University Graduate School of Medicine, Suita, Osaka, Japan., Shiode R; Department of Orthopaedic Surgery, Osaka University Graduate School of Medicine, Suita, Osaka, Japan., Miyamura S; Department of Orthopaedic Surgery, Osaka University Graduate School of Medicine, Suita, Osaka, Japan., Oka K; Department of Orthopaedic Surgery, Osaka University Graduate School of Medicine, Suita, Osaka, Japan., Okada S; Department of Orthopaedic Surgery, Osaka University Graduate School of Medicine, Suita, Osaka, Japan., Tanaka H; Department of Sports Medical Science, Osaka University Graduate School of Medicine, Suita, Osaka, Japan. |
| Πηγή: | Brain and behavior [Brain Behav] 2026 Feb; Vol. 16 (2), pp. e71256. |
| Τύπος έκδοσης: | Journal Article |
| Γλώσσα: | English |
| Στοιχεία περιοδικού: | Publisher: John Wiley & Sons Country of Publication: United States NLM ID: 101570837 Publication Model: Print Cited Medium: Internet ISSN: 2162-3279 (Electronic) NLM ISO Abbreviation: Brain Behav Subsets: MEDLINE |
| Imprint Name(s): | Original Publication: Hoboken, NJ : John Wiley & Sons |
| Ιατρικοί όροι (MeSH): | Neuronal Plasticity*/physiology , Motor Neurons*/physiology , Motor Neurons*/pathology , Sciatic Nerve*/injuries , Pyramidal Tracts*/physiopathology , Pyramidal Tracts*/pathology , Peripheral Nerve Injuries*/physiopathology , Spinal Cord*/physiopathology, Interneurons/physiology ; Cholinergic Neurons/physiology ; Animals ; Rats ; Disease Models, Animal ; Rats, Sprague-Dawley ; Female |
| Περίληψη: | Background and Aim: Changes in neural plasticity crucially modulate functional recovery after central nerve injury. To describe morphological peripheral nerve injury-related changes, we comprehensively elucidated post-sciatic nerve transection (post-SNT) plasticity changes in the lumbar spinal corticospinal tract (CST), motor neurons, and cholinergic interneurons (CINs). Methods: In a rat SNT model, we compared post-SNT changes in lumbar spinal cord plasticity at 2, 4, and 6 weeks with those in the Sham group. Using neural tracers and immunohistochemistry, we labeled and analyzed the CST axonal number and volume, motor neuron cell-body volume and synaptic inputs, and cholinergic interneuron (CIN) (medial and lateral, based on the distance from the central canal) number and synaptic inputs. Results: Compared to the Sham group, the SNT groups showed no significant post-SNT changes in CST axonal number and volume. Motor neuron cell-body volume decreased by 29% at 6 weeks post-SNT, and vesicular glutamate transporter 1 (vGlut1) and vesicular acetylcholine transporter (vAchT) synaptic inputs decreased by 82-93% and 27-42%, respectively, from 2 weeks post-SNT onward. From 2 weeks post-SNT onward, cell numbers were maintained, although vGlut1 synaptic inputs increased by 98%-68% in lateral CINs. At 6 weeks post-SNT, a 44% reduction in cell numbers and a simultaneous 107% increase in vGlut1 synaptic inputs were noted in medial CINs. Conclusion: Following SNT, although CST axonal numbers remained unchanged, plasticity changes were observed in motor neurons and in CINs. CINs exhibited distinct plasticity changes depending on their localization. (© 2026 The Author(s). Brain and Behavior published by Wiley Periodicals LLC.) |
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| Grant Information: | T21K0902490 Japan Society for the Promotion of Science (JSPS) KAKENHI |
| Contributed Indexing: | Keywords: cholinergic interneurons; corticospinal tract; plasticity changes; sciatic nerve transection |
| Entry Date(s): | Date Created: 20260206 Date Completed: 20260707 Latest Revision: 20260707 |
| Update Code: | 20260707 |
| PubMed Central ID: | PMC12876045 |
| DOI: | 10.1002/brb3.71256 |
| PMID: | 41645428 |
| Βάση Δεδομένων: | MEDLINE |
| ISSN: | 2162-3279 |
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| DOI: | 10.1002/brb3.71256 |