Academic Journal
Resolution of penile calciphylaxis in a high-risk dialysis patient with medical therapy and wound care.
| Τίτλος: | Resolution of penile calciphylaxis in a high-risk dialysis patient with medical therapy and wound care. |
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| Συγγραφείς: | Smani S; Department of Urology, Yale School of Medicine, New Haven, Connecticut, USA., Cahill E; Department of Urology, Yale School of Medicine, New Haven, Connecticut, USA., Honig SC; Department of Urology, Yale School of Medicine, New Haven, Connecticut, USA., Rotker K; Department of Urology, Yale School of Medicine, New Haven, Connecticut, USA katherine.rotker@yale.edu. |
| Πηγή: | BMJ case reports [BMJ Case Rep] 2026 Feb 05; Vol. 19 (2). Date of Electronic Publication: 2026 Feb 05. |
| Τύπος έκδοσης: | Journal Article; Case Reports |
| Γλώσσα: | English |
| Στοιχεία περιοδικού: | Publisher: BMJ Pub. Group Country of Publication: England NLM ID: 101526291 Publication Model: Electronic Cited Medium: Internet ISSN: 1757-790X (Electronic) Linking ISSN: 1757790X NLM ISO Abbreviation: BMJ Case Rep Subsets: MEDLINE |
| Imprint Name(s): | Original Publication: London : BMJ Pub. Group |
| Ιατρικοί όροι (MeSH): | Calciphylaxis*/therapy , Calciphylaxis*/etiology , Calciphylaxis*/diagnosis , Kidney Failure, Chronic*/complications , Kidney Failure, Chronic*/therapy , Penile Diseases*/therapy , Penile Diseases*/etiology , Penile Diseases*/diagnosis , Renal Dialysis*/adverse effects , Thiosulfates*/therapeutic use , Thiosulfates*/administration & dosage, Chelating Agents/therapeutic use ; Chelating Agents/administration & dosage ; Penis/pathology ; Humans ; Male ; Treatment Outcome |
| Περίληψη: | Penile calciphylaxis is a rare but life-threatening manifestation of calcific uraemic arteriolopathy, most often seen in patients with end-stage renal disease (ESRD) on dialysis. Its diagnosis is frequently delayed, and its presence carries a poor overall prognosis. Given its rarity, treatment strategies and their efficacy have been understudied and may include observation, medical therapy, radical surgery or hyperbaric oxygen therapy. In this case, we describe a patient with ESRD presenting with a rapidly progressive penile lesion ultimately diagnosed as penile calciphylaxis. Our patient was ineligible for hyperbaric oxygen therapy and declined surgical management. Consequently, unlike many reported cases requiring surgical management nonetheless resulting in poor outcomes, our patient experienced lesional resolution with conservative therapy, specifically intravenous sodium thiosulfate and structured wound care with medical-grade honey, within 9 months after presentation. This case highlights a novel non-surgical approach to a difficult clinical situation and shows the potential efficacy and novelty of non-surgical management in select patients where penile calciphylaxis is diagnosed early in its course. (© BMJ Publishing Group Limited 2026. No commercial re-use. See rights and permissions. Published by BMJ Group.) |
| Competing Interests: | Competing interests: None declared. |
| Contributed Indexing: | Keywords: Genital ulcers; Urology |
| Substance Nomenclature: | HX1032V43M (sodium thiosulfate) 0 (Thiosulfates) 0 (Chelating Agents) |
| Entry Date(s): | Date Created: 20260205 Date Completed: 20260706 Latest Revision: 20260706 |
| Update Code: | 20260707 |
| DOI: | 10.1136/bcr-2025-269829 |
| PMID: | 41644201 |
| Βάση Δεδομένων: | MEDLINE |
| ISSN: | 1757-790X |
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| DOI: | 10.1136/bcr-2025-269829 |