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Overnight sleep affects the stability of neuropsychological classification in mild cognitive impairment.

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Τίτλος: Overnight sleep affects the stability of neuropsychological classification in mild cognitive impairment.
Συγγραφείς: Chang JH; Neurological Sciences, University of Nebraska Medical Center, Omaha, Nebraska, USA., Latona GJ; Neurological Sciences, University of Nebraska Medical Center, Omaha, Nebraska, USA., Rizzo M; Neurological Sciences, University of Nebraska Medical Center, Omaha, Nebraska, USA., Phatak V; Neurological Sciences, University of Nebraska Medical Center, Omaha, Nebraska, USA., Murman DL; Neurological Sciences, University of Nebraska Medical Center, Omaha, Nebraska, USA.
Πηγή: Alzheimer's & dementia : the journal of the Alzheimer's Association [Alzheimers Dement] 2026 Jan; Vol. 22 (1), pp. e71128.
Τύπος έκδοσης: Journal Article
Γλώσσα: English
Στοιχεία περιοδικού: Publisher: John Wiley & Sons, Ltd Country of Publication: United States NLM ID: 101231978 Publication Model: Print Cited Medium: Internet ISSN: 1552-5279 (Electronic) Linking ISSN: 15525260 NLM ISO Abbreviation: Alzheimers Dement Subsets: MEDLINE
Imprint Name(s): Publication: 2020- : Hoboken, NJ : John Wiley & Sons, Ltd.
Original Publication: Orlando, FL : Elsevier, Inc.
Ιατρικοί όροι (MeSH): Cognitive Dysfunction*/classification , Cognitive Dysfunction*/diagnosis , Cognitive Dysfunction*/physiopathology , Cognitive Dysfunction*/psychology , Sleep*/physiology , Neuropsychological Tests*, Humans ; Female ; Male ; Aged ; Actigraphy ; Sleep Duration ; Aged, 80 and over
Περίληψη: Introduction: Reversion to normal cognition in mild cognitive impairment (MCI) is relatively common. This study tested whether total sleep time (TST) and sleep efficiency (SE) on the night before cognitive testing predicts MCI reversion.
Methods: Fifty-eight community-dwelling older adults with MCI (mean age = 75 years) participated. MCI was defined as cognitive performance ≥ 1.5 standard deviation below norms in at least one domain, with preserved daily functioning. Participants completed cognitive testing at baseline and 1-year follow-up, and sleep was objectively measured using actigraphy at baseline. Logistic regression assessed whether prior-night TST and SE predicts reversion, adjusting for age and sex.
Results: Sixteen participants (27.6%) reverted. Shorter prior-night TST was associated with higher odds of reversion, whereas SE showed no significant association. Random night or chronic sleep measures showed no associations.
Discussion: Acute sleep disruption may transiently impair cognition and contribute to MCI misclassification. Sleep screening before testing may improve diagnostic reliability.
Highlights: Shorter total sleep time on the night before cognitive testing was associated with higher odds of mild cognitive impairment (MCI) reversion after 1 year. Sleep efficiency, random-night sleep, and 14-day average sleep showed no significant association with MCI reversion. Single-domain MCI cases were more likely to revert than multi-domain MCI cases, suggesting greater susceptibility to acute factors such as poor sleep. Brief screening of prior-night sleep or actigraphy-derived metrics could help identify low-reliability assessment and improve diagnostic stability in MCI research.
(© 2026 The Author(s). Alzheimer's & Dementia published by Wiley Periodicals LLC on behalf of Alzheimer's Association.)
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Grant Information: 5R01AG017177-18 National Institutes of Health, National Institute on Aging
Contributed Indexing: Keywords: actigraphy; mild cognitive impairment; mild cognitive impairment reversion; neuropsychology; sleep
Entry Date(s): Date Created: 20260126 Date Completed: 20260630 Latest Revision: 20260805
Update Code: 20260805
PubMed Central ID: PMC12832612
DOI: 10.1002/alz.71128
PMID: 41582314
Βάση Δεδομένων: MEDLINE
Περιγραφή
ISSN:1552-5279
DOI:10.1002/alz.71128