Academic Journal
Survival of lung cancer patients with central nervous system metastases: from clinical trials to mouse models.
| Τίτλος: | Survival of lung cancer patients with central nervous system metastases: from clinical trials to mouse models. |
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| Συγγραφείς: | Yang H; Department of Critical Care Medicine, Seventh People's Hospital of Shanghai University of Traditional Chinese Medicine, 358 Datong Road, Pudong New District, Shanghai, 200137, China., Wang C; Shanghai Laboratory Animal Research Center, 3577 Jinke Road, Pudong New District, Shanghai, 201203, China., Ye H; Department of Critical Care Medicine, Seventh People's Hospital of Shanghai University of Traditional Chinese Medicine, 358 Datong Road, Pudong New District, Shanghai, 200137, China., Lin T; Department of Neurosurgery, Guangdong Sanjiu Brain Hospital, Guangzhou, 510510, China., Yuan W; Department of Critical Care Medicine, Seventh People's Hospital of Shanghai University of Traditional Chinese Medicine, 358 Datong Road, Pudong New District, Shanghai, 200137, China., Shan C; Department of Oncology, Guangdong Sanjiu Brain Hospital, Guangzhou, 510510, China., Hu Q; Department of Oncology, Guangdong Sanjiu Brain Hospital, Guangzhou, 510510, China., Jin X; Department of Neurosurgery, Guangdong Sanjiu Brain Hospital, Guangzhou, 510510, China., Liu D; Department of Neurosurgery, Guangdong Sanjiu Brain Hospital, Guangzhou, 510510, China., Wen L; Department of Radiation Oncology, Zhujiang Hospital, Southern Medical University, 253 Gongye Dadao, Guangdong, 510280, Guangzhou, China. wenlei1998@sina.com., Lei M; Department of Critical Care Medicine, Seventh People's Hospital of Shanghai University of Traditional Chinese Medicine, 358 Datong Road, Pudong New District, Shanghai, 200137, China. Minglei_dr@163.com. |
| Πηγή: | Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico [Clin Transl Oncol] 2026 Jul; Vol. 28 (7), pp. 2701-2710. Date of Electronic Publication: 2026 Jan 23. |
| Τύπος έκδοσης: | Journal Article |
| Γλώσσα: | English |
| Στοιχεία περιοδικού: | Publisher: Country of Publication: Italy NLM ID: 101247119 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1699-3055 (Electronic) Linking ISSN: 1699048X NLM ISO Abbreviation: Clin Transl Oncol Subsets: MEDLINE |
| Imprint Name(s): | Publication: <2010- >: Milan : Springer Italia Original Publication: Barcelona, Spain : Doyma, c2005- |
| Ιατρικοί όροι (MeSH): | Lung Neoplasms*/pathology , Lung Neoplasms*/mortality , Carcinoma, Non-Small-Cell Lung*/mortality , Carcinoma, Non-Small-Cell Lung*/secondary , Carcinoma, Non-Small-Cell Lung*/pathology , Brain Neoplasms*/secondary , Brain Neoplasms*/mortality , Meningeal Carcinomatosis*/secondary , Meningeal Carcinomatosis*/mortality, Meningeal Neoplasms/secondary ; Meningeal Neoplasms/mortality ; Animals ; Mice ; Humans ; Male ; Disease Models, Animal ; Female ; Retrospective Studies ; Middle Aged ; Aged ; Survival Rate ; Prognosis ; Adult ; Clinical Trials as Topic |
| Περίληψη: | Background: Central nervous system (CNS) metastasis is common in patients with non-small cell lung cancer (NSCLC) and is associated with poor prognosis. Evidence guiding optimal clinical management remains limited, and comprehensive studies on animal models that recapitulate different CNS metastatic patterns are lacking. Methods: A total of 316 NSCLC patients with CNS metastases were retrospectively enrolled between May 2019 and February 2024. Patients were categorized into four groups: brain metastases only (BM, n = 145), leptomeningeal metastases only (LM, n = 43), concurrent brain and leptomeningeal metastases (BM+LM, n = 62), and brain metastases preceding leptomeningeal metastases (BM-LM, n = 66). Overall survival was analyzed using survival curves. To explore the distinct biological processes underlying BM and LM, mouse models of brain metastasis were established using tail vein, internal carotid artery, and left ventricular injection methods. Results: Survival analysis demonstrated that patients with LM had significantly shorter overall survival compared with those with BM alone (P < 0.05). Patients with concurrent BM and LM also exhibited poorer overall survival than those in whom BM preceded LM (P < 0.01). In animal experiments, brain metastasis developed in one of five mice following tail vein injection, one of five following internal carotid artery injection, and two of five following left ventricular injection, indicating the highest success rate with the latter approach. None of the animal models successfully reproduced the sequential progression from brain metastasis to leptomeningeal metastasis. Conclusion: Leptomeningeal involvement in NSCLC is associated with significantly worse survival outcomes compared with brain metastasis alone. Although several injection strategies can generate brain metastasis in mice, current models fail to simulate the transition from brain metastasis to leptomeningeal metastasis, highlighting the need for improved and more representative animal models. (© 2026. The Author(s), under exclusive licence to Federación de Sociedades Españolas de Oncología (FESEO).) |
| Competing Interests: | Declarations. Conflict of interests: The authors declare that they have no competing interests. Ethical approval: This study was conducted in accordance with the Declaration of Helsinki and approved by the Ethics Committee of Guangdong Sanjiu Brain Hospital. We informed the participants about the study and obtained informed consent from each patient. Meanwhile this study was carried out in compliance with institutional guidelines and was approved by the Animal Care and Use Committee of Shanghai Seventh People's Hospital. Consent for publication: Not applicable. |
| References: | Ann Oncol. 2002 May;13(5):748-54. (PMID: 12075744) Clin Cancer Res. 2016 Oct 15;22(20):5130-5140. (PMID: 27435396) J Thorac Oncol. 2013 Dec;8(12):1570-3. (PMID: 24389440) Onco Targets Ther. 2020 Sep 04;13:8837-8844. (PMID: 32943887) Clin Cancer Res. 2022 Aug 2;28(15):3318-3328. (PMID: 35404402) Eur J Cancer. 2015 Nov;51(17):2508-16. (PMID: 26277099) J Vis Exp. 2021 Dec 14;(178):. (PMID: 34978300) Sci Rep. 2022 Dec 26;12(1):22372. (PMID: 36572759) Lancet Oncol. 2018 Jan;19(1):e43-e55. (PMID: 29304362) Anticancer Res. 2012 Nov;32(11):4655-62. (PMID: 23155227) J Thorac Oncol. 2013 Feb;8(2):185-91. (PMID: 23328548) Int J Cancer. 2024 Jan 1;154(1):169-179. (PMID: 37611176) J Cancer. 2020 Oct 21;11(24):7283-7290. (PMID: 33193892) J Vis Exp. 2022 Oct 21;(188):. (PMID: 36342167) J Thorac Oncol. 2015 Dec;10(12):1754-61. (PMID: 26334749) J Neurosurg. 2000 Dec;93(6):927-31. (PMID: 11117864) Cancer Radiother. 2015 Feb;19(1):3-9. (PMID: 25636729) J Thorac Oncol. 2016 Nov;11(11):1962-1969. (PMID: 27539328) Oncotarget. 2016 Jan 26;7(4):3847-56. (PMID: 26716903) Curr Oncol Rep. 2012 Feb;14(1):48-54. (PMID: 22012633) Cancer Res. 2011 Jul 15;71(14):4932-43. (PMID: 21622714) Cancer Res. 1988 Jun 15;48(12):3478-84. (PMID: 3370643) Front Pharmacol. 2021 Sep 24;12:750031. (PMID: 34630120) Clin Neurol Neurosurg. 2023 Feb;225:107572. (PMID: 36610238) World Neurosurg. 2018 May;113:e1-e9. (PMID: 29104152) Nat Genet. 2020 Apr;52(4):371-377. (PMID: 32203465) Neurosurg Focus. 2023 Oct;55(4):E3. (PMID: 37778050) |
| Grant Information: | 82174189 Natural Science Foundation of Xiamen Municipality; 82304920 Natural Science Foundation of Xiamen Municipality |
| Contributed Indexing: | Keywords: Animal models; Brain metastasis; Leptomeningeal metastases |
| Entry Date(s): | Date Created: 20260123 Date Completed: 20260619 Latest Revision: 20261010 |
| Update Code: | 20261010 |
| DOI: | 10.1007/s12094-025-04125-3 |
| PMID: | 41575665 |
| Βάση Δεδομένων: | MEDLINE |
| ISSN: | 1699-3055 |
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| DOI: | 10.1007/s12094-025-04125-3 |