Academic Journal
Three-year efficacy and safety of repeated low-level red-light therapy for myopia control: a multicentre real-world study.
| Τίτλος: | Three-year efficacy and safety of repeated low-level red-light therapy for myopia control: a multicentre real-world study. |
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| Συγγραφείς: | Chen Y; State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangdong Provincial Key Laboratory of Ophthalmology and Visual Science, Guangdong Provincial Clinical Research Center for Ocular Diseases, Guangzhou, 510060, Guangdong, China., Wang W; State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangdong Provincial Key Laboratory of Ophthalmology and Visual Science, Guangdong Provincial Clinical Research Center for Ocular Diseases, Guangzhou, 510060, Guangdong, China., Xiong R; State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangdong Provincial Key Laboratory of Ophthalmology and Visual Science, Guangdong Provincial Clinical Research Center for Ocular Diseases, Guangzhou, 510060, Guangdong, China., Yu F; Shenzhen Guangming District People's Hospital, Shenzhen, Guangdong, China mingguang_he@yahoo.com 253910137@qq.com., Pan S; The Second Affiliated Hospital of Wannan Medical College, Wuhu, Anhui, China., Dong J; The First Affiliated Hospital of Baotou Medical College, Baotou, Inner Mongolia, China., Zhang J; State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangdong Provincial Key Laboratory of Ophthalmology and Visual Science, Guangdong Provincial Clinical Research Center for Ocular Diseases, Guangzhou, 510060, Guangdong, China., Zhu Z; Centre for Eye Research Australia, Royal Victorian Eye and Ear Hospital, East Melbourne, Victoria, Australia., Ding X; State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangdong Provincial Key Laboratory of Ophthalmology and Visual Science, Guangdong Provincial Clinical Research Center for Ocular Diseases, Guangzhou, 510060, Guangdong, China., Wang B; The First Affiliated Hospital of Baotou Medical College, Baotou, Inner Mongolia, China., Chen Y; School of Optometry, The Hong Kong Polytechnic University, Hong Kong, China.; Research Centre for SHARP Vision (RCSV), The Hong Kong Polytechnic University, Hong Kong, China., Chan HH; School of Optometry, The Hong Kong Polytechnic University, Hong Kong, China., Choi KY; School of Optometry, The Hong Kong Polytechnic University, Hong Kong, China., Chan SSH; School of Optometry, The Hong Kong Polytechnic University, Hong Kong, China., Zheng Y; State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangdong Provincial Key Laboratory of Ophthalmology and Visual Science, Guangdong Provincial Clinical Research Center for Ocular Diseases, Guangzhou, 510060, Guangdong, China., Shi D; School of Optometry, The Hong Kong Polytechnic University, Hong Kong, China.; Research Centre for SHARP Vision (RCSV), The Hong Kong Polytechnic University, Hong Kong, China., Aung Y; Imperial College London, London, England, UK., Kishi S; Maebashi Central Eye Clinic, Maebashi, Japan., Ohno-Matsui K; Department of Ophthalmology and Visual Science, Institute of Science Tokyo, Tokyo, Japan., He M; School of Optometry, The Hong Kong Polytechnic University, Hong Kong, China mingguang_he@yahoo.com 253910137@qq.com.; Research Centre for SHARP Vision (RCSV), The Hong Kong Polytechnic University, Hong Kong, China.; InnoHK, Centre for Eye and Vision Research (CEVR), 17W Hong Kong Science Park, Hong Kong, China. |
| Πηγή: | The British journal of ophthalmology [Br J Ophthalmol] 2026 Aug 20; Vol. 110 (9), pp. 1028-1035. Date of Electronic Publication: 2026 Aug 20. |
| Τύπος έκδοσης: | Journal Article; Multicenter Study |
| Γλώσσα: | English |
| Στοιχεία περιοδικού: | Publisher: BMJ Pub. Group Country of Publication: England NLM ID: 0421041 Publication Model: Electronic Cited Medium: Internet ISSN: 1468-2079 (Electronic) Linking ISSN: 00071161 NLM ISO Abbreviation: Br J Ophthalmol Subsets: MEDLINE |
| Imprint Name(s): | Publication: Jan. 1992- : London : BMJ Pub. Group Original Publication: 1917-Dec. 1991: London : British Medical Association |
| Ιατρικοί όροι (MeSH): | Refraction, Ocular*/physiology , Myopia*/physiopathology , Myopia*/therapy , Myopia*/diagnosis , Red Light*, Visual Acuity/physiology ; Humans ; Child ; Adolescent ; Female ; Male ; Treatment Outcome ; Disease Progression ; Follow-Up Studies ; Time Factors |
| Περίληψη: | Background: To evaluate the efficacy and safety of repeated low-level red-light (RLRL) therapy for controlling myopia progression over 3 years in real-world settings. Methods: This multicentre cohort study included participants currently undergoing RLRL treatment, identified from electronic medical databases in three hospitals (myopic children and adolescents aged 7-18 years, who were prescribed RLRL therapy from 1 June 2018 to 1 June 2023), using stratified random sampling based on RLRL treatment duration (≥0.5-1 year, ≥1-2 years, ≥2-3 years and ≥3 years), with approximately 90 participants in each group. All participants voluntarily received RLRL therapy twice a daily (3 min/session, ≥4-hour interval), 5-7 days/week. Results: Among 362 participants, 90 were treated for ≥0.5-1 year (median 0.64 year), 91 for ≥1-2 years (median 1.40 years), 90 for ≥2-3 years (median 2.30 years) and 91 for ≥3 years (median 3.65 years). The satisfactory myopia control rate (defined as annual axial elongation ≤0.10 mm) was 72.53% (95% CI 62.17 to 81.37) over ≥3 years of RLRL treatment, with annual axial length change of 0.06 mm/year (95% CI 0.03 to 0.08). No subjective visual function damage was documented by best-corrected visual acuity, and no treatment duration-dependent changes in objective full-field electroretinogram were observed. A minimal, reversible optical coherence tomography change was noted in four eyes which did not impact visual function. Conclusions: This real-world study demonstrates that RLRL therapy provides promising long-term efficacy and safety in myopia control over 3 years among Chinese myopic children and adolescents. Trial Registration Number: NCT05871840. (© Author(s) (or their employer(s)) 2026. No commercial re-use. See rights and permissions. Published by BMJ Group.) |
| Competing Interests: | Competing interests: MH and ZZ are listed as inventors on the patents and patent applications related to the study (CN201910490186.6). MH is a director and shareholder in Eyerising Ltd and Eyerising International Pty Ltd. No other potential conflicts of interest relevant to this article were reported. |
| Contributed Indexing: | Keywords: Child health (paediatrics); Clinical Trial; Epidemiology; Optics and Refraction |
| Molecular Sequence: | ClinicalTrials.gov NCT05871840 |
| Entry Date(s): | Date Created: 20260120 Date Completed: 20260820 Latest Revision: 20260909 |
| Update Code: | 20260909 |
| DOI: | 10.1136/bjo-2025-328687 |
| PMID: | 41558834 |
| Βάση Δεδομένων: | MEDLINE |
| ISSN: | 1468-2079 |
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| DOI: | 10.1136/bjo-2025-328687 |