Academic Journal
Cellular senescence as a therapeutic target for aging intervention.
| Τίτλος: | Cellular senescence as a therapeutic target for aging intervention. |
|---|---|
| Συγγραφείς: | Bi Y; Henan Academy of Sciences, Zhengzhou, China; State Key Laboratory of Epigenetic Regulation and Intervention, Institute of Biophysics, Chinese Academy of Sciences, Beijing, China. Electronic address: youkunbi@ibp.ac.cn., Ji G; Henan Academy of Sciences, Zhengzhou, China; State Key Laboratory of Epigenetic Regulation and Intervention, Institute of Biophysics, Chinese Academy of Sciences, Beijing, China. Electronic address: gj28@ibp.ac.cn. |
| Πηγή: | Biomedical journal [Biomed J] 2026 Jun; Vol. 49 (3), pp. 100948. Date of Electronic Publication: 2026 Jan 17. |
| Τύπος έκδοσης: | Journal Article; Review; Research Support, Non-U.S. Gov't |
| Γλώσσα: | English |
| Στοιχεία περιοδικού: | Publisher: Elsevier Country of Publication: United States NLM ID: 101599820 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2320-2890 (Electronic) Linking ISSN: 23194170 NLM ISO Abbreviation: Biomed J Subsets: MEDLINE |
| Imprint Name(s): | Publication: Dec. 2015- : New York : Elsevier Original Publication: Mumbai : Medknow |
| Ιατρικοί όροι (MeSH): | Cellular Senescence*/physiology , Cellular Senescence*/drug effects , Aging*/physiology , Aging*/drug effects, Immunotherapy/methods ; Senotherapeutics/therapeutic use ; Humans ; Animals |
| Περίληψη: | Cellular senescence is a stress-induced cellular state that contributes to tissue dysfunction, chronic inflammation, and a broad range of aging-associated pathologies. The accumulation of senescent cells (SnCs) disrupt normal tissue function, positioning them as drivers of pathological decline and therapeutic targets for aging intervention. Accordingly, multiple senescence-targeted strategies have been developed, including senolytics, senomorphics, senescence immunotherapy, and restoration-oriented interventions. These approaches aim to mitigate senescence-driven pathology by eliminating senescent cells, modulating their secretory activity, or restoring cellular function. Ongoing advancements will require precise stratification of senescent states, careful assessment of long-term safety, and the integration of optimized delivery systems for targeted therapeutic outcomes. (Copyright © 2026 The Authors. Published by Elsevier B.V. All rights reserved.) |
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| Contributed Indexing: | Keywords: Cellular senescence; Restoration-oriented interventions; Senescence immunotherapy; Senolytics; Senomorphics |
| Substance Nomenclature: | 0 (Senotherapeutics) |
| Entry Date(s): | Date Created: 20260119 Date Completed: 20260629 Latest Revision: 20260922 |
| Update Code: | 20260922 |
| PubMed Central ID: | PMC13226813 |
| DOI: | 10.1016/j.bj.2026.100948 |
| PMID: | 41554408 |
| Βάση Δεδομένων: | MEDLINE |
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