Academic Journal
Cellular senescence as a therapeutic target for aging intervention.
| Τίτλος: | Cellular senescence as a therapeutic target for aging intervention. |
|---|---|
| Συγγραφείς: | Bi Y; Henan Academy of Sciences, Zhengzhou, China; State Key Laboratory of Epigenetic Regulation and Intervention, Institute of Biophysics, Chinese Academy of Sciences, Beijing, China. Electronic address: youkunbi@ibp.ac.cn., Ji G; Henan Academy of Sciences, Zhengzhou, China; State Key Laboratory of Epigenetic Regulation and Intervention, Institute of Biophysics, Chinese Academy of Sciences, Beijing, China. Electronic address: gj28@ibp.ac.cn. |
| Πηγή: | Biomedical journal [Biomed J] 2026 Jun; Vol. 49 (3), pp. 100948. Date of Electronic Publication: 2026 Jan 17. |
| Τύπος έκδοσης: | Journal Article; Review; Research Support, Non-U.S. Gov't |
| Γλώσσα: | English |
| Στοιχεία περιοδικού: | Publisher: Elsevier Country of Publication: United States NLM ID: 101599820 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2320-2890 (Electronic) Linking ISSN: 23194170 NLM ISO Abbreviation: Biomed J Subsets: MEDLINE |
| Imprint Name(s): | Publication: Dec. 2015- : New York : Elsevier Original Publication: Mumbai : Medknow |
| Ιατρικοί όροι (MeSH): | Cellular Senescence*/physiology , Cellular Senescence*/drug effects , Aging*/physiology , Aging*/drug effects, Immunotherapy/methods ; Senotherapeutics/therapeutic use ; Humans ; Animals |
| Περίληψη: | Cellular senescence is a stress-induced cellular state that contributes to tissue dysfunction, chronic inflammation, and a broad range of aging-associated pathologies. The accumulation of senescent cells (SnCs) disrupt normal tissue function, positioning them as drivers of pathological decline and therapeutic targets for aging intervention. Accordingly, multiple senescence-targeted strategies have been developed, including senolytics, senomorphics, senescence immunotherapy, and restoration-oriented interventions. These approaches aim to mitigate senescence-driven pathology by eliminating senescent cells, modulating their secretory activity, or restoring cellular function. Ongoing advancements will require precise stratification of senescent states, careful assessment of long-term safety, and the integration of optimized delivery systems for targeted therapeutic outcomes. (Copyright © 2026 The Authors. Published by Elsevier B.V. All rights reserved.) |
| References: | Cell Res. 2013 Dec;23(12):1337-8. (PMID: 23979017) Biomed Pharmacother. 2025 Nov;192:118571. (PMID: 41016153) Aging Cell. 2025 Aug;24(8):e70108. (PMID: 40375481) Nat Aging. 2021 Dec;1(12):1117-1126. (PMID: 37117524) Nat Commun. 2020 Mar 24;11(1):1545. (PMID: 32210226) Elife. 2022 May 04;11:. (PMID: 35507395) Cells. 2022 Jun 19;11(12):. (PMID: 35741095) Biochem Soc Trans. 2024 Aug 28;52(4):1661-1671. (PMID: 38940746) Front Cell Dev Biol. 2023 Aug 11;11:1233259. (PMID: 37635867) Aging Cell. 2024 Feb;23(2):e14039. (PMID: 38040663) NPJ Aging. 2024 Feb 6;10(1):12. (PMID: 38321020) Cell. 2019 Oct 31;179(4):813-827. (PMID: 31675495) Biomolecules. 2025 Jun 13;15(6):. (PMID: 40563501) Inflamm Regen. 2024 Jun 3;44(1):28. (PMID: 38831382) Atherosclerosis. 2023 Jan;364:10-19. (PMID: 36455344) Nature. 2020 Dec;588(7836):124-129. (PMID: 33268865) EBioMedicine. 2017 Jul;21:21-28. (PMID: 28416161) Nat Rev Cancer. 2019 Aug;19(8):439-453. (PMID: 31235879) Exp Mol Med. 2018 Jan 26;50(1):e432. (PMID: 29371695) Cell. 2025 Apr 17;188(8):2043-2062. (PMID: 40250404) J Cardiol. 2022 Jan;79(1):134-143. (PMID: 34518076) Nat Commun. 2020 Jan 2;11(1):37. (PMID: 31896747) Nat Commun. 2020 Apr 24;11(1):1996. (PMID: 32332723) Trends Cell Biol. 2018 Jun;28(6):436-453. (PMID: 29477613) Nat Commun. 2023 Jan 11;14(1):156. (PMID: 36631445) Nat Rev Nephrol. 2016 Jun;12(6):325-38. (PMID: 27108839) Cell Death Dis. 2025 Oct 24;16(1):757. (PMID: 41136356) Nat Aging. 2025 Jun;5(6):1159-1175. (PMID: 40442321) Cell Res. 2016 Feb;26(2):147-8. (PMID: 26794872) Nat Commun. 2020 Apr 22;11(1):1935. (PMID: 32321921) Atherosclerosis. 2014 Sep;236(1):91-100. (PMID: 25016363) Aging Cell. 2025 Jan;24(1):e14361. (PMID: 39402753) Cell. 2023 Jan 19;186(2):243-278. (PMID: 36599349) Arthritis Res Ther. 2022 Jul 22;24(1):174. (PMID: 35869508) Nat Commun. 2017 Sep 4;8(1):422. (PMID: 28871086) Lancet Oncol. 2010 Dec;11(12):1149-59. (PMID: 21094089) Cell. 2024 Aug 8;187(16):4150-4175. (PMID: 39121846) Nat Biotechnol. 2025 Sep;43(9):1413-1415. (PMID: 40610798) PNAS Nexus. 2024 Dec 03;3(12):pgae499. (PMID: 39660064) Nat Commun. 2025 Jul 1;16(1):5672. (PMID: 40593617) Aging Cell. 2022 May;21(5):e13602. (PMID: 35363946) Front Pharmacol. 2025 Sep 29;16:1666698. (PMID: 41089832) Nat Commun. 2025 Mar 31;16(1):3079. (PMID: 40159497) Cell. 2025 Oct 16;188(21):5895-5911.e17. (PMID: 40816266) NPJ Aging. 2024 Oct 24;10(1):48. (PMID: 39448585) Nat Metab. 2021 Dec;3(12):1706-1726. (PMID: 34873338) Science. 2020 Apr 24;368(6489):. (PMID: 32327570) Cell. 2024 Oct 31;187(22):6358-6378.e29. (PMID: 39270656) Nat Aging. 2025 Aug;5(8):1528-1547. (PMID: 40660002) Exp Mol Med. 2023 Apr;55(4):794-805. (PMID: 37009796) EBioMedicine. 2019 Sep;47:446-456. (PMID: 31542391) Respir Investig. 2023 Nov;61(6):781-792. (PMID: 37741093) Nat Aging. 2024 Jan;4(1):14-26. (PMID: 38102454) Aging Cell. 2024 May;23(5):e14178. (PMID: 38685568) Int J Mol Med. 2024 Mar;53(3):. (PMID: 38240118) Signal Transduct Target Ther. 2021 Nov 26;6(1):402. (PMID: 34824210) Mech Ageing Dev. 2024 Dec;222:111995. (PMID: 39384074) Genome Biol. 2020 Jun 2;21(1):130. (PMID: 32487174) EMBO J. 2025 Oct;44(19):5239-5243. (PMID: 40883506) Trends Biotechnol. 2026 May;44(5):1230-1242. (PMID: 40975650) Cell Death Dis. 2016 Oct 27;7(10):e2441. (PMID: 27787519) PLoS Biol. 2020 Jan 16;18(1):e3000599. (PMID: 31945054) Trends Cell Biol. 2025 Mar;35(3):248-257. (PMID: 39025762) Nat Med. 2015 Dec;21(12):1424-35. (PMID: 26646499) Nat Rev Drug Discov. 2025 Jan;24(1):57-71. (PMID: 39548312) J Clin Invest. 2022 Aug 1;132(15):. (PMID: 35912854) Nature. 2014 May 22;509(7501):439-46. (PMID: 24848057) Aging Cell. 2015 Aug;14(4):644-58. (PMID: 25754370) Nat Rev Drug Discov. 2017 Oct;16(10):718-735. (PMID: 28729727) Acta Pharmacol Sin. 2023 Oct;44(10):2065-2074. (PMID: 37225845) Signal Transduct Target Ther. 2022 Sep 9;7(1):313. (PMID: 36075909) Signal Transduct Target Ther. 2023 May 13;8(1):200. (PMID: 37179335) Nat Aging. 2026 Jan;6(1):108-126. (PMID: 41291258) Aging Cell. 2021 Dec;20(12):e13486. (PMID: 34734460) Int Immunopharmacol. 2024 Oct 25;140:112894. (PMID: 39126736) Aging (Albany NY). 2020 Jun 25;12(12):11337-11348. (PMID: 32584785) Nat Aging. 2025 Jul;5(7):1249-1265. (PMID: 40437307) Science. 2024 Jun 21;384(6702):1300-1301. (PMID: 38900869) Cardiovasc Res. 2025 Dec 9;121(15):2385-2403. (PMID: 41325078) Nat Med. 2018 Aug;24(8):1246-1256. (PMID: 29988130) Nat Med. 2022 Aug;28(8):1556-1568. (PMID: 35953721) Int J Mol Sci. 2025 May 19;26(10):. (PMID: 40429989) Geroscience. 2025 Jun;47(3):4577-4600. (PMID: 39982668) Cell Stem Cell. 2022 Dec 1;29(12):1637-1652.e6. (PMID: 36459967) Nat Commun. 2021 May 25;12(1):3094. (PMID: 34035273) Nat Med. 2016 Jan;22(1):78-83. (PMID: 26657143) JCI Insight. 2023 Apr 24;8(8):. (PMID: 36853800) NPJ Aging. 2025 May 2;11(1):31. (PMID: 40316527) FASEB J. 2025 Jan 31;39(2):e70362. (PMID: 39878685) iScience. 2024 Feb 01;27(3):109032. (PMID: 38380252) J Agric Food Chem. 2018 Aug 8;66(31):8291-8298. (PMID: 30040414) J Clin Invest. 2013 Mar;123(3):966-72. (PMID: 23454759) Aging Dis. 2024 Feb 1;16(1):432-453. (PMID: 38377021) Front Pharmacol. 2022 Oct 10;13:1015835. (PMID: 36299900) Cell Biosci. 2022 May 31;12(1):74. (PMID: 35642067) Science. 2019 Mar 8;363(6431):. (PMID: 30846571) Mol Pharmacol. 2024 Jan 10;105(2):64-74. (PMID: 38164616) Trends Cell Biol. 2024 Mar;34(3):255-267. (PMID: 37648593) Sci Transl Med. 2024 Sep 11;16(764):eadg1777. (PMID: 39259812) Nat Aging. 2022 Mar;2(3):243-253. (PMID: 37118377) Mol Metab. 2022 Dec;66:101601. (PMID: 36116755) Sci Transl Med. 2023 Aug 16;15(709):eadd1951. (PMID: 37585504) Nat Metab. 2019 Nov;1(11):1074-1088. (PMID: 31799499) Proc Natl Acad Sci U S A. 2015 Nov 17;112(46):E6301-10. (PMID: 26578790) Molecules. 2017 Sep 12;22(9):. (PMID: 28895883) EBioMedicine. 2025 Dec;122:106015. (PMID: 41202471) J Osteoporos. 2023 Feb 22;2023:5572754. (PMID: 36875869) EBioMedicine. 2018 Oct;36:18-28. (PMID: 30279143) Cell. 2023 Mar 30;186(7):1417-1431.e20. (PMID: 37001502) Food Funct. 2019 May 22;10(5):2970-2985. (PMID: 31074472) EBioMedicine. 2023 Apr;90:104481. (PMID: 36857968) Nat Cell Biol. 2017 Sep;19(9):1061-1070. (PMID: 28759028) Ann Vasc Surg. 2026 Jan;122:76-85. (PMID: 40553844) Nat Aging. 2021 Oct;1(10):870-879. (PMID: 34841261) Free Radic Biol Med. 2025 Dec 1;240:597-614. (PMID: 40818742) Bone Res. 2024 Dec 3;12(1):69. (PMID: 39627227) Nat Commun. 2017 Feb 23;8:14532. (PMID: 28230051) Geroscience. 2023 Oct;45(5):2785-2803. (PMID: 37261678) Aging Cell. 2023 Feb;22(2):e13767. (PMID: 36637079) Proc Natl Acad Sci U S A. 2024 Apr 30;121(18):e2311028121. (PMID: 38657052) Mol Ther Methods Clin Dev. 2019 May 30;14:64-76. (PMID: 31312666) Cell Metab. 2025 Feb 04;37(2):527-541.e6. (PMID: 39818209) Nature. 2018 Oct;562(7728):578-582. (PMID: 30232451) Front Cardiovasc Med. 2021 Feb 10;7:625215. (PMID: 33644124) Oxid Med Cell Longev. 2015;2015:392169. (PMID: 26180587) Aging Cell. 2025 Sep;24(9):e70167. (PMID: 40624910) Trends Cell Biol. 2023 Jan;33(1):9-17. (PMID: 35599179) Int J Mol Med. 2020 Jan;45(1):195-209. (PMID: 31746373) Front Pharmacol. 2022 Jul 25;13:921003. (PMID: 35959426) Science. 2021 Jan 15;371(6526):265-270. (PMID: 33446552) Nat Rev Mol Cell Biol. 2024 Dec;25(12):958-978. (PMID: 38654098) Bone. 2019 Apr;121:16-28. (PMID: 30610968) Cell Metab. 2016 Feb 9;23(2):303-14. (PMID: 26686024) JCI Insight. 2024 Jan 23;9(2):. (PMID: 38051584) JCI Insight. 2023 Apr 24;8(8):. (PMID: 36853800) Nat Commun. 2018 Dec 21;9(1):5435. (PMID: 30575733) BMB Rep. 2019 Jan;52(1):47-55. (PMID: 30526770) Nat Med. 2024 Feb;30(2):443-454. (PMID: 38321220) Front Pharmacol. 2022 Aug 23;13:952560. (PMID: 36081941) Aging (Albany NY). 2016 Nov 30;8(11):3120-3130. (PMID: 27922820) Aging Cell. 2024 Apr;23(4):e14154. (PMID: 38553952) EMBO J. 2025 Dec;44(23):7295-7325. (PMID: 41162753) J Clin Invest. 2018 Apr 2;128(4):1229-1237. (PMID: 29608139) Nat Med. 2023 Oct;29(10):2481-2488. (PMID: 37679434) Exp Mol Med. 2025 Jul;57(7):1482-1491. (PMID: 40634753) Nat Med. 2025 Sep;31(9):3047-3061. (PMID: 40855191) Alzheimers Res Ther. 2020 Apr 21;12(1):45. (PMID: 32317025) Trends Cell Biol. 2018 Aug;28(8):595-607. (PMID: 29704982) Aging Dis. 2024 May 7;15(3):977-1005. (PMID: 37611906) Nat Aging. 2023 Jul;3(7):776-790. (PMID: 37400722) Aging Cell. 2020 Dec;19(12):e13270. (PMID: 33166065) Aging Cell. 2025 May;24(5):e14489. (PMID: 39823170) Nat Aging. 2024 Apr;4(4):464-482. (PMID: 38622408) Cancer Chemother Pharmacol. 2014 Sep;74(3):593-602. (PMID: 25053389) iScience. 2023 Sep 27;26(10):108082. (PMID: 37860765) Nat Metab. 2024 Jul;6(7):1329-1346. (PMID: 39009762) Nat Rev Mol Cell Biol. 2024 Dec;25(12):1001-1023. (PMID: 38831121) Autophagy. 2019 Aug;15(8):1460-1462. (PMID: 31066320) Nature. 2023 Jan;613(7942):169-178. (PMID: 36544018) BMC Physiol. 2010 Jun 22;10:11. (PMID: 20569453) JCI Insight. 2024 Jan 23;9(2):. (PMID: 38051584) Nat Rev Drug Discov. 2018 May;17(5):377. (PMID: 29651106) Nat Rev Mol Cell Biol. 2021 Feb;22(2):75-95. (PMID: 33328614) J Exp Med. 2024 Apr 1;221(4):. (PMID: 38385946) Nature. 2016 Feb 11;530(7589):184-9. (PMID: 26840489) Nat Commun. 2020 May 18;11(1):2482. (PMID: 32424156) Front Pharmacol. 2021 Nov 15;12:689880. (PMID: 34867315) Signal Transduct Target Ther. 2025 Jul 4;10(1):210. (PMID: 40610404) Cell Res. 2020 Jul;30(7):574-589. (PMID: 32341413) Cell Metab. 2016 Jun 14;23(6):1060-1065. (PMID: 27304507) Phytomedicine. 2025 Jul;142:156787. (PMID: 40315640) Immun Ageing. 2024 Jun 26;21(1):43. (PMID: 38926847) Cell Mol Immunol. 2025 Jul;22(7):712-729. (PMID: 40481182) Mol Metab. 2025 Jan;91:102065. (PMID: 39557194) Nature. 2023 Aug;620(7973):374-380. (PMID: 37532932) Nat Commun. 2016 Apr 06;7:11190. (PMID: 27048913) Am J Physiol Heart Circ Physiol. 2025 Jul 1;329(1):H191-H205. (PMID: 40338175) Cell. 2016 Sep 8;166(6):1386-1396. (PMID: 27610565) Genes Dev. 2017 Aug 1;31(15):1529-1534. (PMID: 28877934) EMBO J. 2019 Mar 1;38(5):. (PMID: 30737259) |
| Contributed Indexing: | Keywords: Cellular senescence; Restoration-oriented interventions; Senescence immunotherapy; Senolytics; Senomorphics |
| Substance Nomenclature: | 0 (Senotherapeutics) |
| Entry Date(s): | Date Created: 20260119 Date Completed: 20260629 Latest Revision: 20260922 |
| Update Code: | 20260922 |
| PubMed Central ID: | PMC13226813 |
| DOI: | 10.1016/j.bj.2026.100948 |
| PMID: | 41554408 |
| Βάση Δεδομένων: | MEDLINE |
| ISSN: | 2320-2890 |
|---|---|
| DOI: | 10.1016/j.bj.2026.100948 |