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Alcohol Use Disorder versus Adverse In-Hospital Outcomes after Radical Cystectomy and Ileal Conduit Urinary Diversion.

Λεπτομέρειες βιβλιογραφικής εγγραφής
Τίτλος: Alcohol Use Disorder versus Adverse In-Hospital Outcomes after Radical Cystectomy and Ileal Conduit Urinary Diversion.
Συγγραφείς: Polverino F; Cancer Prognostics and Health Outcomes Unit, Division of Urology, University of Montréal Health Center, Montréal, QC, Canada. fedepolve97@gmail.com.; Department of Neurosciences, Science of Reproduction and Odontostomatology, University of Naples Federico II, Naples, Italy. fedepolve97@gmail.com., Catanzaro C; Cancer Prognostics and Health Outcomes Unit, Division of Urology, University of Montréal Health Center, Montréal, QC, Canada.; Division of Urology, IRCCS Azienda Ospedaliero-universitaria di Bologna, Bologna, Italy., Nicolazzini M; Cancer Prognostics and Health Outcomes Unit, Division of Urology, University of Montréal Health Center, Montréal, QC, Canada.; Division of Urology, Department of Translational Medicine, University of Eastern Piedmont, Maggiore della Carità Hospital, Novara, Italy., Petix M; Cancer Prognostics and Health Outcomes Unit, Division of Urology, University of Montréal Health Center, Montréal, QC, Canada.; Department of Urology, IEO European Institute of Oncology, IRCCS, Milan, Italy.; Università degli Studi di Milano, Milan, Italy., Quarta L; Cancer Prognostics and Health Outcomes Unit, Division of Urology, University of Montréal Health Center, Montréal, QC, Canada.; Vita-Salute San Raffaele University, Milan, Italy.; Division of Experimental Oncology/Unit of Urology, URI, Urological Research Institute, IRCCS San Raffaele Scientific Institute, Milan, Italy., Filzmayer M; Cancer Prognostics and Health Outcomes Unit, Division of Urology, University of Montréal Health Center, Montréal, QC, Canada.; Department of Urology, Goethe University Frankfurt, University Hospital, Frankfurt am Main, Germany., Goyal JA; Cancer Prognostics and Health Outcomes Unit, Division of Urology, University of Montréal Health Center, Montréal, QC, Canada., Morra S; Cancer Prognostics and Health Outcomes Unit, Division of Urology, University of Montréal Health Center, Montréal, QC, Canada.; Department of Neurosciences, Science of Reproduction and Odontostomatology, University of Naples Federico II, Naples, Italy., Califano G; Department of Neurosciences, Science of Reproduction and Odontostomatology, University of Naples Federico II, Naples, Italy., Collà Ruvolo C; Cancer Prognostics and Health Outcomes Unit, Division of Urology, University of Montréal Health Center, Montréal, QC, Canada.; Department of Neurosciences, Science of Reproduction and Odontostomatology, University of Naples Federico II, Naples, Italy., La Rocca R; Department of Neurosciences, Science of Reproduction and Odontostomatology, University of Naples Federico II, Naples, Italy., Briganti A; Vita-Salute San Raffaele University, Milan, Italy.; Division of Experimental Oncology/Unit of Urology, URI, Urological Research Institute, IRCCS San Raffaele Scientific Institute, Milan, Italy., Chun FKH; Department of Urology, Goethe University Frankfurt, University Hospital, Frankfurt am Main, Germany., Palumbo C; Division of Urology, Department of Translational Medicine, University of Eastern Piedmont, Maggiore della Carità Hospital, Novara, Italy., Schiavina R; Division of Urology, IRCCS Azienda Ospedaliero-universitaria di Bologna, Bologna, Italy., Musi G; Department of Urology, IEO European Institute of Oncology, IRCCS, Milan, Italy.; Università degli Studi di Milano, Milan, Italy., Shariat SF; Department of Urology, Comprehensive Cancer Center, Medical University of Vienna, Vienna, Austria.; Department of Urology, Weill Cornell Medical College, New York, NY, USA.; Department of Urology, University of Texas Southwestern Medical Center, Dallas, TX, USA.; Hourani Center for Applied Scientific Research, Al-Ahliyya Amman University, Amman, Jordan., Saad F; Cancer Prognostics and Health Outcomes Unit, Division of Urology, University of Montréal Health Center, Montréal, QC, Canada., Longo N; Department of Neurosciences, Science of Reproduction and Odontostomatology, University of Naples Federico II, Naples, Italy., Karakiewicz PI; Cancer Prognostics and Health Outcomes Unit, Division of Urology, University of Montréal Health Center, Montréal, QC, Canada.
Πηγή: Annals of surgical oncology [Ann Surg Oncol] 2026 Jun; Vol. 33 (6), pp. 5847-5853. Date of Electronic Publication: 2026 Jan 12.
Τύπος έκδοσης: Journal Article
Γλώσσα: English
Στοιχεία περιοδικού: Publisher: Springer Country of Publication: United States NLM ID: 9420840 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1534-4681 (Electronic) Linking ISSN: 10689265 NLM ISO Abbreviation: Ann Surg Oncol Subsets: MEDLINE
Imprint Name(s): Publication: 2005- : New York, NY : Springer
Original Publication: New York, NY : Raven Press, c1994-
Ιατρικοί όροι (MeSH): Cystectomy*/adverse effects , Cystectomy*/mortality , Urinary Diversion*/adverse effects , Urinary Diversion*/mortality , Urinary Bladder Neoplasms*/surgery , Urinary Bladder Neoplasms*/pathology , Postoperative Complications*/etiology , Alcoholism*/complications, Length of Stay/statistics & numerical data ; Humans ; Female ; Male ; Hospital Mortality ; Aged ; Middle Aged ; Prognosis ; Survival Rate ; Follow-Up Studies
Περίληψη: Background: Radical cystectomy (RC) is the gold standard treatment for muscle-invasive bladder cancer (BCa). Alcohol use disorder (AUD) may predispose to worse adverse in-hospital outcomes after RC and ileal conduit urinary diversion. The current study addressed this knowledge gap.
Patients and Methods: Descriptive analyses, propensity score matching (PSM), and multivariable logistic and Poisson regression models were used to address patients with BCa treated with RC and ileal conduit within National Inpatient Sample (2006-2019).
Results: Of 15,018 RC and ileal conduit patients, 320 (2.1%) had history of AUD at baseline. Compared with their non-AUD counterparts, patients with AUD exhibited significantly higher rates of adverse in-hospital outcomes in 9 of 14 categories, namely: critical care therapies (Δ + 12.0%), overall complications (Δ + 11.0%), prolonged length of stay (Δ + 11.0%), pulmonary complications (Δ + 6.0%), acute kidney injury (Δ + 5.0%), hepatic complications (Δ + 3.2%), in-hospital mortality (Δ + 2.8%), cardiac complications (Δ + 1.6%), and total hospital charges (Δ + 7925 US$, all p < 0.05). After multivariable adjustment, AUD independently predicted higher rates of adverse in-hospital outcomes in the same 9 of 15 categories, namely: hepatic complications [odds ratio (OR) 3.3], in-hospital mortality (OR 3.2), acute kidney injury (OR 1.7), overall complications (OR 1.7), cardiac complications (OR 1.5), critical care therapies (OR 1.4), prolonged length of stay (OR 1.3), pulmonary complications (OR 1.2), and total hospital charges (OR 1.2, all p < 0.01).
Conclusions: Since AUD significantly predisposes to higher rates of adverse in-hospital outcomes and in-hospital mortality after RC and ileal conduit urinary diversion, precautionary measures prior to admission and during hospital stay may be warranted in patients with AUD.
(© 2026. Society of Surgical Oncology.)
Competing Interests: Disclosure: The authors have nothing to report.
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Contributed Indexing: Keywords: Alcohol use disorder; Complications; Cystectomy; NIS; Urinary bladder cancer
Entry Date(s): Date Created: 20260112 Date Completed: 20260626 Latest Revision: 20260626
Update Code: 20260626
DOI: 10.1245/s10434-025-19018-6
PMID: 41524880
Βάση Δεδομένων: MEDLINE
Περιγραφή
ISSN:1534-4681
DOI:10.1245/s10434-025-19018-6