Academic Journal
Migrations and Tuberculosis: A comparative study of Mycobacterium tuberculosis genomic population structure in Brazil and Mozambique to historical triangular slave trade knowledge to reconstruct the origins of tuberculosis infections caused by Lineage 1 in Brazil.
| Τίτλος: | Migrations and Tuberculosis: A comparative study of Mycobacterium tuberculosis genomic population structure in Brazil and Mozambique to historical triangular slave trade knowledge to reconstruct the origins of tuberculosis infections caused by Lineage 1 in Brazil. |
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| Συγγραφείς: | Morel-Journel T; Université Sorbonne Paris Nord, Université Paris Cité, INSERM, IAME, Bobigny, France., Guyeux C; Institut FEMTO-ST, UMR, 6174, CNRS, Université de Franche-Comté, France., Sola C; Université Paris-Saclay, INSERM, IAME, Gif-sur-Yvette, France. Electronic address: christophe.sola@universite-paris-saclay.fr. |
| Πηγή: | Tuberculosis (Edinburgh, Scotland) [Tuberculosis (Edinb)] 2026 Mar; Vol. 157, pp. 102734. Date of Electronic Publication: 2026 Jan 05. |
| Τύπος έκδοσης: | Journal Article; Comparative Study; Historical Article |
| Γλώσσα: | English |
| Στοιχεία περιοδικού: | Publisher: Churchill Livingstone Country of Publication: Scotland NLM ID: 100971555 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-281X (Electronic) Linking ISSN: 14729792 NLM ISO Abbreviation: Tuberculosis (Edinb) Subsets: MEDLINE |
| Imprint Name(s): | Original Publication: Edinburgh, New York : Churchill Livingstone, c2001- |
| Ιατρικοί όροι (MeSH): | Mycobacterium tuberculosis*/genetics , Mycobacterium tuberculosis*/classification , Tuberculosis*/history , Tuberculosis*/microbiology , Tuberculosis*/epidemiology , Tuberculosis*/transmission , Enslavement*/history , Enslaved Persons*, Brazil/epidemiology ; Mozambique/epidemiology ; Humans ; Genotype ; History, 19th Century ; History, 16th Century ; Genome, Bacterial ; History, 18th Century ; History, 17th Century ; Genomics |
| Περίληψη: | Lineage 1 is an ancestral lineage of the Mycobacterium tuberculosis complex (MTBC) comprising five sublineages. In a previous study, we suggested that a representative of sublineage L1.1.3, present in both Mozambique and northern Brazil, SIT129, may have been brought to Brazil by sea during the long history of slavery that lasted, between Africa and Brazil, from the early 16th century to the mid-19th century. In this study, using a combination of new comparative genomics results and human migration data extracted from the SlaveVoyages.org database, we sought to more precisely reconstruct the scenario for the introduction of L1 genotypes into Brazil. We present results showing substantial similarities between the MTBC population structure in present-day Mozambique and Brazil across three subclades, L1.1.2, L1.1.3, and L1.2.2, and convergent historical data. Indeed, several introductions between the 16th and 19th centuries could explain the higher contemporary prevalence of L1 in northern Brazil. Our data do not allow us to decide between a direct introduction of L1 isolates into northern Brazil and intra-Brazilian transmission from the main southern ports, which seems likely. Other less likely scenarios are also discussed. (Copyright © 2026 The Authors. Published by Elsevier Ltd.. All rights reserved.) |
| Competing Interests: | Declaration of competing interest All authors declare that the article was not submitted elsewhere and that none of the authors have competing interest. |
| Entry Date(s): | Date Created: 20260109 Date Completed: 20260312 Latest Revision: 20260625 |
| Update Code: | 20260626 |
| DOI: | 10.1016/j.tube.2026.102734 |
| PMID: | 41512342 |
| Βάση Δεδομένων: | MEDLINE |
| ISSN: | 1873-281X |
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| DOI: | 10.1016/j.tube.2026.102734 |