Academic Journal
A prospective randomized pilot study comparing fibrin glue, buried suture knot and exposed suture knot techniques for conjunctival closure in bilateral symmetrical fornix approach squint surgery.
| Τίτλος: | A prospective randomized pilot study comparing fibrin glue, buried suture knot and exposed suture knot techniques for conjunctival closure in bilateral symmetrical fornix approach squint surgery. |
|---|---|
| Συγγραφείς: | Agarwal NB; Department of Pediatric Ophthalmology, Strabismus and Neuro-Ophthalmology, Shantilal Shanghvi Eye Institute, Mumbai, India., Sheth JN; Department of Pediatric Ophthalmology, Strabismus and Neuro-Ophthalmology, Shantilal Shanghvi Eye Institute, Mumbai, India., Nanavati H; Department of Pediatric Ophthalmology, Strabismus and Neuro-Ophthalmology, Shantilal Shanghvi Eye Institute, Mumbai, India., Sharma SS; Department of Cornea and Anterior Segment Services, Shantilal Shanghvi Eye Institute, Mumbai, India., Naik M; Department of Cataract Services, Shantilal Shanghvi Eye Institute, Mumbai, India., Gupta R; Faculty Optometrist, Shantilal Shanghvi Eye Institute, Mumbai, India. |
| Πηγή: | Strabismus [Strabismus] 2026 Sep; Vol. 34 (3), pp. 308-315. Date of Electronic Publication: 2026 Jan 05. |
| Τύπος έκδοσης: | Journal Article; Randomized Controlled Trial; Comparative Study; Research Support, Non-U.S. Gov't |
| Γλώσσα: | English |
| Στοιχεία περιοδικού: | Publisher: Informa Healthcare Country of Publication: England NLM ID: 9310896 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1744-5132 (Electronic) Linking ISSN: 09273972 NLM ISO Abbreviation: Strabismus Subsets: MEDLINE |
| Imprint Name(s): | Publication: London : Informa Healthcare Original Publication: Buren, The Netherlands : Aeolus Press, c1993- |
| Ιατρικοί όροι (MeSH): | Fibrin Tissue Adhesive*/therapeutic use , Conjunctiva*/surgery , Conjunctiva*/diagnostic imaging , Strabismus*/surgery , Suture Techniques*/instrumentation , Tissue Adhesives*/therapeutic use , Ophthalmologic Surgical Procedures*/methods , Oculomotor Muscles*/surgery , Sutures*, Humans ; Pilot Projects ; Female ; Male ; Prospective Studies ; Adult ; Middle Aged ; Tomography, Optical Coherence ; Child ; Adolescent ; Young Adult ; Follow-Up Studies |
| Περίληψη: | Purpose: This study compared fibrin glue (FG), buried suture knot (BSK), and exposed suture knot (ESK) for conjunctival closure in bilateral symmetrical squint surgery through fornix incision. Method: This study enrolled patients over 10-years age undergoing bilateral, symmetric strabismus surgery. Pre-operative anterior segment optical coherence tomography (ASOCT) and slit-lamp photography were performed on the pre-determined surgical quadrant. All the patients underwent strabismus surgery using a fornix incision. Eyes were randomized using a block design to one of the 3 conjunctival closure groups. Conjunctival closure time was recorded. Post-operative assessments were conducted at 1 day, 1 week, 2 weeks, and 6 weeks. These assessments included: patient-reported pain, foreign body sensation (FB), itching, watering. Clinical signs of conjunctival hyperemia, discharge, and chemosis were assessed using a standardized scale. ASOCT and slit-lamp photography of the surgical site were done at each post-operative visit. Conjunctival thickness was measured from ASOCT images. Statistical analysis was performed by SPSS 23.0 version. Variables with p value < 0.05 were considered as statistically significant. Results: A total of 30 eyes were randomized to FG, BSK, or ESK group. The FG group demonstrated significantly faster conjunctival closure time (37.2 ± 29.0 s) compared to BSK (171.6 ± 53.1 s) and ESK (148.7 ± 51.0 s) (p < .001). Patient-reported symptoms were similar across groups; however, FG showed significantly greater comfort than BSK at two-weeks (p = .030). Objectively, FG exhibited significantly less inflammation than ESK at one-week (p = .013) and BSK at two-weeks (p = .015). Both BSK and ESK eyes and not FG eyes showed a significant increase in conjunctival thickness at six-weeks when compared to their pre-operative thickness. The BSK group developed a significantly thicker conjunctiva at two-weeks compared to both FG (p = .033) and ESK (p = .022). Complications in the FG group included one eye each with wound gaping and bacterial surgical site infection, while the ESK group had one eye with Tenon-cyst. Conclusion: Long-term patient comfort was comparable across all closure methods following fornix incision strabismus surgery. FG significantly reduced surgical time and early objective inflammation, offering an efficiency advantage. Both BSK and ESK techniques showed no significant difference in postoperative outcome or long-term comfort. |
| Contributed Indexing: | Keywords: ASOCT; conjunctiva thickness; inflammation; patient comfort; wound gaping |
| Substance Nomenclature: | 0 (Fibrin Tissue Adhesive) 0 (Tissue Adhesives) |
| Entry Date(s): | Date Created: 20260105 Date Completed: 20260904 Latest Revision: 20260927 |
| Update Code: | 20260927 |
| DOI: | 10.1080/09273972.2025.2612517 |
| PMID: | 41487057 |
| Βάση Δεδομένων: | MEDLINE |
| ISSN: | 1744-5132 |
|---|---|
| DOI: | 10.1080/09273972.2025.2612517 |