Academic Journal
Metal-free deformylation strategy enables sustainable Hantzsch-type pyridine synthesis in neat water.
| Τίτλος: | Metal-free deformylation strategy enables sustainable Hantzsch-type pyridine synthesis in neat water. |
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| Συγγραφείς: | Yang XY; College of Pharmacy, National & Local Joint Engineering Research Center of Targeted and Innovative Therapeutics, Chongqing Key Laboratory of Kinase Modulators as Innovative Medicine, Chongqing University of Arts and Sciences, Chongqing, 402160, China., Li X; College of Pharmacy, National & Local Joint Engineering Research Center of Targeted and Innovative Therapeutics, Chongqing Key Laboratory of Kinase Modulators as Innovative Medicine, Chongqing University of Arts and Sciences, Chongqing, 402160, China., Xu J; College of Pharmacy, National & Local Joint Engineering Research Center of Targeted and Innovative Therapeutics, Chongqing Key Laboratory of Kinase Modulators as Innovative Medicine, Chongqing University of Arts and Sciences, Chongqing, 402160, China., Liao HM; College of Pharmacy, National & Local Joint Engineering Research Center of Targeted and Innovative Therapeutics, Chongqing Key Laboratory of Kinase Modulators as Innovative Medicine, Chongqing University of Arts and Sciences, Chongqing, 402160, China., Xu ZG; College of Pharmacy, National & Local Joint Engineering Research Center of Targeted and Innovative Therapeutics, Chongqing Key Laboratory of Kinase Modulators as Innovative Medicine, Chongqing University of Arts and Sciences, Chongqing, 402160, China., Lei J; College of Pharmacy, National & Local Joint Engineering Research Center of Targeted and Innovative Therapeutics, Chongqing Key Laboratory of Kinase Modulators as Innovative Medicine, Chongqing University of Arts and Sciences, Chongqing, 402160, China. jlei0916@163.com., Chen ZZ; College of Pharmacy, National & Local Joint Engineering Research Center of Targeted and Innovative Therapeutics, Chongqing Key Laboratory of Kinase Modulators as Innovative Medicine, Chongqing University of Arts and Sciences, Chongqing, 402160, China. 18883138277@163.com. |
| Πηγή: | Molecular diversity [Mol Divers] 2026 Aug; Vol. 30 (4), pp. 5439-5447. Date of Electronic Publication: 2026 Jan 03. |
| Τύπος έκδοσης: | Journal Article |
| Γλώσσα: | English |
| Στοιχεία περιοδικού: | Publisher: ESCOM Science Publishers Country of Publication: Netherlands NLM ID: 9516534 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1573-501X (Electronic) Linking ISSN: 13811991 NLM ISO Abbreviation: Mol Divers Subsets: MEDLINE |
| Imprint Name(s): | Original Publication: Leiden, The Netherlands : ESCOM Science Publishers, c1995- |
| Ιατρικοί όροι (MeSH): | Pyridines*/chemical synthesis , Pyridines*/chemistry , Water*/chemistry, Metals/chemistry ; Chemistry Techniques, Synthetic ; Green Chemistry Technology |
| Περίληψη: | A deformylation-driven multicomponent reaction to access Hantzsch-type pyridine was first realized via a domino Michael/retro-Michael/Aldol/deformylation cascade. This operationally simple protocol fulfills green chemistry principles by employing readily available feedstocks in neat water under metal-free conditions. Mechanistic investigations establish deformylation of 3-formylchromones is the pivotal activation step, enabling the domino pathway toward pyridines while circumventing energy-intensive decarboxylation. Unprecedented in scope, the strategy accommodates diverse electrophiles and functionalized chromones, achieving 58-85% yields. This rationally designed deformylation cascade provides a sustainable blueprint for synthesizing medicinally important heterocycles without transition-metal contamination. (© 2025. The Author(s), under exclusive licence to Springer Nature Switzerland AG.) |
| Competing Interests: | Declarations. Competing interests: The authors declare no competing interests. |
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| Contributed Indexing: | Keywords: Deformylation; Metal-Free; Multicomponent reaction; Pyridine; Water |
| Substance Nomenclature: | 0 (Pyridines) 059QF0KO0R (Water) NH9L3PP67S (pyridine) 0 (Metals) |
| Entry Date(s): | Date Created: 20260103 Date Completed: 20260704 Latest Revision: 20261010 |
| Update Code: | 20261010 |
| DOI: | 10.1007/s11030-025-11442-w |
| PMID: | 41483314 |
| Βάση Δεδομένων: | MEDLINE |
| ISSN: | 1573-501X |
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| DOI: | 10.1007/s11030-025-11442-w |