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Time to recovery and predictors of neonatal sepsis among neonates admitted to intensive care units in Southern ethiopia: multicenter study.

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Τίτλος: Time to recovery and predictors of neonatal sepsis among neonates admitted to intensive care units in Southern ethiopia: multicenter study.
Συγγραφείς: Geneti E; Department of Pediatrics and Child Health Nursing, Salale University, Fiche, Ethiopia., Dibissa T; Department of Nursing, Wachemo University, Hossana, Ethiopia., Zewdu T; Department of Nursing, Salale University, Fiche, Ethiopia. tesfuzewdu23@gmail.com., Gemechu T; Department of Pediatrics and Child Health Nursing, Salale University, Fiche, Ethiopia., Mamo A; Department of Pediatrics and Child Health Nursing, Debre Brehan University, Debre Berhan, Ethiopia., Tessema M; Department of Neonatology, Debre Brehan University, Debre Brehan, Ethiopia., Birhanu B; Department of Pediatrics and Child Health Nursing, Wachemo University, Hossana, Ethiopia.
Πηγή: Scientific reports [Sci Rep] 2025 Dec 31; Vol. 16 (1), pp. 244. Date of Electronic Publication: 2025 Dec 31.
Τύπος έκδοσης: Journal Article; Multicenter Study
Γλώσσα: English
Στοιχεία περιοδικού: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 101563288 Publication Model: Electronic Cited Medium: Internet ISSN: 2045-2322 (Electronic) Linking ISSN: 20452322 NLM ISO Abbreviation: Sci Rep Subsets: MEDLINE
Imprint Name(s): Original Publication: London : Nature Publishing Group, copyright 2011-
Ιατρικοί όροι (MeSH): Neonatal Sepsis*/epidemiology , Neonatal Sepsis*/therapy , Intensive Care Units, Neonatal*, Ethiopia/epidemiology ; Humans ; Infant, Newborn ; Female ; Male ; Retrospective Studies ; Time Factors
Περίληψη: Neonatal sepsis is a serious problem in the first 28 days of life which is a leading cause of morbidity and mortality in developing counties. Neonatal sepsis remains a leading cause of neonatal morbidity and mortality, particularly in Sub-Saharan Africa. There is paucity of multicenter studies in this region. Therefore, this study aimed to assess the burden and predictors of recovery time among neonates with neonatal sepsis admitted to neonatal intensive care units in South Ethiopia. A retrospective follow up study was conducted among 643 charts of neonates with neonatal sepsis who were admitted to NICU in hospitals of Southern Ethiopia using systematic random sampling. Data were inputted into Epi data version 3.1 and exported to STATA 14 for analysis. Cox Proportional Hazard regression model was used. P-value < 0.05 in multivariable analysis was used to declare the result as statistically significant predictors of recovery from neonatal sepsis. The overall median recovery time was 8 days. The incidence rate of recovery from neonatal sepsis was 9.86 per 100 neonate day’s observation. Factors significantly associated with recovery time of neonatal sepsis includes; respiratory distress (AHR: 0.71, 95% CI (0.59, 0.85)), resuscitation at birth (AHR: 0.65, 95% CI (0.49, 0.87)), having fever (AHR: 0.82, 95% CI (0.67, 0.99)) and frequency of antibiotics change (AHR: 2.0, 95% CI (1.57, 2.63)). Time to recovery of neonatal sepsis was moderately acceptable as compared to the previous studies. It was significantly affected by resuscitation at birth, frequent antibiotic change, respiratory distress and fever. Therefore, health care providers must pay more attention for prevention and early intervention of complication.
Competing Interests: Declarations. Competing interests: The authors declare no competing interests. Ethics approval and consent to participate: Ethical clearance and approval for this study was obtained from the research ethical review committee of College of Medicine and Health Sciences, Debre Brehan University (protocol number IRB-148). Also, a permission letter was obtained from each hospital manager before the full scale data collection. An informed consent was waived by the ethics committee of College of Medicine and Health Sciences, Debre Brehan University because the study was conducted through review of medical charts. Patients’ names were not recorded. All procedures were performed in accordance with the relevant guidelines and regulations.
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Contributed Indexing: Keywords: Neonate; Recovery and sepsis
Entry Date(s): Date Created: 20251231 Date Completed: 20260626 Latest Revision: 20260729
Update Code: 20260729
PubMed Central ID: PMC12770574
DOI: 10.1038/s41598-025-29473-6
PMID: 41476185
Βάση Δεδομένων: MEDLINE
Περιγραφή
ISSN:2045-2322
DOI:10.1038/s41598-025-29473-6