Academic Journal
Per- and Polyfluoroalkyl Substances and Hand Osteoarthritis: Data From the Osteoarthritis Initiative.
| Τίτλος: | Per- and Polyfluoroalkyl Substances and Hand Osteoarthritis: Data From the Osteoarthritis Initiative. |
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| Συγγραφείς: | Driban JB; Department of Population and Quantitative Health Sciences, UMass Chan Medical School, Worcester, Massachusetts., Rokoff LB; Center for Interdisciplinary and Population Health Research, MaineHealth Institute for Research, Westbrook, Maine., Lu B; Department of Public Health Sciences, UConn Health, Farmington, Connecticut., McAlindon TE; Division of Rheumatology, Department of Medicine, UMass Chan Medical School, Worcester, Massachusetts., Eaton CB; Center for Primary Care and Prevention, Kent Hospital, Pawtucket, Rhode Island.; Department of Family Medicine, Warren Alpert Medical School Brown University, Department of Epidemiology, Brown University School of Public Health, Providence, Rhode Island., Roberts MB; Center for Primary Care and Prevention, Kent Hospital, Pawtucket, Rhode Island.; Department of Family Medicine, Warren Alpert Medical School Brown University, Department of Epidemiology, Brown University School of Public Health, Providence, Rhode Island., Mathes D; Environmental and Chemical Laboratory Services, Public Health & Environmental Laboratories, New Jersey Department of Health, Ewing., Lestician C; Environmental and Chemical Laboratory Services, Public Health & Environmental Laboratories, New Jersey Department of Health, Ewing., Xu ZC; Environmental and Chemical Laboratory Services, Public Health & Environmental Laboratories, New Jersey Department of Health, Ewing., Fan ZT; Environmental and Chemical Laboratory Services, Public Health & Environmental Laboratories, New Jersey Department of Health, Ewing., O'Leary SP; Environmental and Chemical Laboratory Services, Public Health & Environmental Laboratories, New Jersey Department of Health, Ewing., Haugen IK; Center for Treatment of Rheumatic and Musculoskeletal Diseases (REMEDY), Diakonhjemmet Hospital, Oslo, Norway., Sellam J; Department of Rheumatology, Saint-Antoine Hospital, Assistance Publique-Hôpitaux de Paris (AP-HP), Centre de Recherche Saint-Antoine (CRSA) Inserm UMRS-938, Sorbonne Université, Paris, France., Courties A; Department of Rheumatology, Saint-Antoine Hospital, Assistance Publique-Hôpitaux de Paris (AP-HP), Centre de Recherche Saint-Antoine (CRSA) Inserm UMRS-938, Sorbonne Université, Paris, France., Fleisch AF; Center for Interdisciplinary and Population Health Research, MaineHealth Institute for Research, Westbrook, Maine.; Pediatric Endocrinology and Diabetes, Maine Medical Center, Portland. |
| Πηγή: | Arthritis & rheumatology (Hoboken, N.J.) [Arthritis Rheumatol] 2026 May; Vol. 78 (5), pp. 1076-1087. Date of Electronic Publication: 2026 Feb 17. |
| Τύπος έκδοσης: | Journal Article; Research Support, Non-U.S. Gov't; Research Support, N.I.H., Extramural |
| Γλώσσα: | English |
| Στοιχεία περιοδικού: | Publisher: Wiley Country of Publication: United States NLM ID: 101623795 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2326-5205 (Electronic) Linking ISSN: 23265191 NLM ISO Abbreviation: Arthritis Rheumatol Subsets: MEDLINE |
| Imprint Name(s): | Original Publication: Malden, MA : Wiley, [2014]- |
| Ιατρικοί όροι (MeSH): | Osteoarthritis*/epidemiology , Osteoarthritis*/blood , Osteoarthritis*/diagnostic imaging , Fluorocarbons*/blood , Hand Joints*/diagnostic imaging, Alkanesulfonic Acids/blood ; Humans ; Female ; Middle Aged ; Aged ; Male ; Disease Progression ; Case-Control Studies ; Logistic Models ; Incidence ; Decanoic Acids |
| Περίληψη: | Objective: To explore whether biologic levels of specific per- and polyfluoroalkyl substances (PFAS) and a mixture of PFAS-reflecting the overall effect and accounting for correlations among PFAS-relate to incident hand osteoarthritis (HOA) and progression. Methods: Among a case-cohort sample from the Osteoarthritis Initiative (n = 1,878), we examined associations of eight PFAS in serum with odds of developing over the subsequent 4 years (1) symptomatic HOA and (2) an increased number of joints with radiographic osteoarthritis (Kellgren-Lawrence ≥2; yes/no). We used weighted logistic regression to assess single PFAS (continuous and quartiles) and quantile g-computation to assess the PFAS mixture in relation to our primary outcomes. Results: Participants were primarily female (58%) and on average aged 62 years and overweight (mean body mass index = 28.6 kg/m2). Participants with higher perfluorodecanoic acid (PFDA) and perfluorononanoic acid (PFNA; continuous variables) had greater odds of incident symptomatic HOA (odds ratio [OR] [95% confidence interval (CI)] per interquartile range increment: PFDA 1.12 [1.05-1.20]; PFNA 1.07 [1.00-1.13]), but associations were not monotonic when these PFAS were represented in quartiles. Participants with higher perfluorohexane sulfonic acid had lower odds of incident HOA (eg, OR 0.94 [95% CI 0.88-1.00] per interquartile range increment). We observed no other consistent associations between PFAS and either outcome. Conclusion: We observed possible associations of PFDA and PFNA serum concentrations with symptomatic HOA incidence, but we otherwise found no consistent evidence that greater PFAS concentrations relate to a greater chance of developing HOA incidence or progression. (© 2025 The Author(s). Arthritis & Rheumatology published by Wiley Periodicals LLC on behalf of American College of Rheumatology.) |
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| Grant Information: | N01-AR-2-2262 United States NH NIH HHS; R01 AR081791 United States AR NIAMS NIH HHS; R01 ES30101 United States ES NIEHS NIH HHS; R01 ES030101 United States ES NIEHS NIH HHS; N01-AR-2-2261 United States NH NIH HHS; N01-AR-2-2260 United States NH NIH HHS; R24 AR085006 United States AR NIAMS NIH HHS; N01-AR-2-2258 United States NH NIH HHS; N01-AR-2-2259 United States NH NIH HHS |
| Substance Nomenclature: | 0 (Fluorocarbons) 335-76-2 (perfluorodecanoic acid) 0 (Alkanesulfonic Acids) FX3WJ41CMX (perflexane) 0 (Decanoic Acids) |
| Entry Date(s): | Date Created: 20251222 Date Completed: 20260430 Latest Revision: 20260904 |
| Update Code: | 20261020 |
| PubMed Central ID: | PMC12917737 |
| DOI: | 10.1002/art.70026 |
| PMID: | 41429602 |
| Βάση Δεδομένων: | MEDLINE |
| ISSN: | 2326-5205 |
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| DOI: | 10.1002/art.70026 |