Academic Journal
Inhibitory Effect of Fucoidan Combined with Bifidobacteria on Helicobacter pylori.
| Τίτλος: | Inhibitory Effect of Fucoidan Combined with Bifidobacteria on Helicobacter pylori. |
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| Συγγραφείς: | Guo L; College of Food Science and Engineering, Jilin Agricultural University, Changchun, Jilin 130118, China., Xuan J; College of Food Science and Engineering, Jilin Agricultural University, Changchun, Jilin 130118, China., Bao S; College of Food Science and Engineering, Jilin Agricultural University, Changchun, Jilin 130118, China., Yang L; College of Food Science and Engineering, Jilin Agricultural University, Changchun, Jilin 130118, China., Li Y; College of Food Science and Engineering, Jilin Agricultural University, Changchun, Jilin 130118, China., Jiang B; College of Food Science and Engineering, Jilin Agricultural University, Changchun, Jilin 130118, China., Wang J; College of Food Science and Engineering, Jilin Agricultural University, Changchun, Jilin 130118, China., Ren D; College of Food Science and Engineering, Jilin Agricultural University, Changchun, Jilin 130118, China. |
| Πηγή: | Journal of agricultural and food chemistry [J Agric Food Chem] 2026 Jan 14; Vol. 74 (1), pp. 1525-1537. Date of Electronic Publication: 2025 Dec 22. |
| Τύπος έκδοσης: | Journal Article |
| Γλώσσα: | English |
| Στοιχεία περιοδικού: | Publisher: American Chemical Society Country of Publication: United States NLM ID: 0374755 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1520-5118 (Electronic) Linking ISSN: 00218561 NLM ISO Abbreviation: J Agric Food Chem Subsets: MEDLINE |
| Imprint Name(s): | Original Publication: Washington, American Chemical Society. |
| Ιατρικοί όροι (MeSH): | Helicobacter pylori*/drug effects , Helicobacter pylori*/physiology , Helicobacter pylori*/genetics , Polysaccharides*/administration & dosage , Helicobacter Infections*/microbiology , Helicobacter Infections*/drug therapy , Helicobacter Infections*/genetics , Helicobacter Infections*/immunology , Bifidobacterium animalis*/growth & development , Bifidobacterium animalis*/physiology , Probiotics*/administration & dosage , Anti-Bacterial Agents*/administration & dosage, NF-kappa B/genetics ; NF-kappa B/metabolism ; Gastric Mucosa/microbiology ; Gastric Mucosa/drug effects ; Toll-Like Receptor 2/genetics ; Toll-Like Receptor 2/metabolism ; Myeloid Differentiation Factor 88/genetics ; Myeloid Differentiation Factor 88/metabolism ; Bacterial Adhesion/drug effects ; Urease/metabolism ; Epithelial Cells/microbiology ; Epithelial Cells/drug effects ; Animals ; Mice ; Humans ; Male ; Mice, Inbred BALB C ; Cell Line |
| Περίληψη: | In the study, fucoidan (FUC) was shown to have antigastric digestive properties and promote the growth of B. animalis BD7, a gastric fluid-resistant, highly aggregative Bifidobacterium. The combination of FUC and B. animalis BD7 significantly inhibited the adhesion of H. pylori SS1 to gastric mucosal epithelial cells (GES-1), decreased urease activity (71.24 ± 3.29%), and promoted the synthesis of bacterial inhibitory substances in vitro, while in vivo, it could alleviate the inflammation of the gastric mucosa of the infected mice, regulate the level of inflammatory factors, and repair the mucosal barrier by a mechanism that is related to the inhibition of the TLR2/MyD88/NF-κB pathway and reversal of bacterial colony disorders. The mechanism is related to the inhibition of the TLR2/MyD88/NF-κB pathway and the reversal of flora disruption. The synergistic effects of the two provide theoretical and practical basis for the development of new anti-H. pylori food and optimization of clinical treatment. |
| Contributed Indexing: | Keywords: B. animalis BD7; adhesion; fucoidan; gastric microbiota; inflammatory response |
| Substance Nomenclature: | 9072-19-9 (fucoidan) 0 (Polysaccharides) 0 (NF-kappa B) 0 (Toll-Like Receptor 2) 0 (Myeloid Differentiation Factor 88) EC 3.5.1.5 (Urease) 0 (Anti-Bacterial Agents) |
| Entry Date(s): | Date Created: 20251222 Date Completed: 20260115 Latest Revision: 20260115 |
| Update Code: | 20260130 |
| DOI: | 10.1021/acs.jafc.5c10441 |
| PMID: | 41428944 |
| Βάση Δεδομένων: | MEDLINE |
| ISSN: | 1520-5118 |
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| DOI: | 10.1021/acs.jafc.5c10441 |