Academic Journal
Preparation of silver-loaded metal-organic frameworks as a novel agent for arresting dental caries of primary teeth.
| Τίτλος: | Preparation of silver-loaded metal-organic frameworks as a novel agent for arresting dental caries of primary teeth. |
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| Συγγραφείς: | Memarpour M; Oral and Dental Disease Research Center, School of Dentistry, Shiraz University of Medical Sciences, Shiraz, Iran., Sharifinejad A; Oral and Dental Disease Research Center, School of Dentistry, Shiraz University of Medical Sciences, Shiraz, Iran. a.sharifi137781@yahoo.com., Alizadeh M; Oral and Dental Disease Research Center, School of Dentistry, Shiraz University of Medical Sciences, Shiraz, Iran., Rafiee A; Oral and Dental Disease Research Center, School of Dentistry, Shiraz University of Medical Sciences, Shiraz, Iran., Vossoughi M; Oral and Dental Disease Research Center, School of Dentistry, Shiraz University of Medical Sciences, Shiraz, Iran. |
| Πηγή: | Scientific reports [Sci Rep] 2025 Dec 12; Vol. 15 (1), pp. 43711. Date of Electronic Publication: 2025 Dec 12. |
| Τύπος έκδοσης: | Journal Article; Research Support, Non-U.S. Gov't |
| Γλώσσα: | English |
| Στοιχεία περιοδικού: | Publisher: Nature Publishing Group Country of Publication: England NLM ID: 101563288 Publication Model: Electronic Cited Medium: Internet ISSN: 2045-2322 (Electronic) Linking ISSN: 20452322 NLM ISO Abbreviation: Sci Rep Subsets: MEDLINE |
| Imprint Name(s): | Original Publication: London : Nature Publishing Group, copyright 2011- |
| Ιατρικοί όροι (MeSH): | Tooth, Deciduous*/drug effects , Dental Caries*/drug therapy , Dental Caries*/prevention & control , Silver*/chemistry , Silver*/pharmacology , Metal-Organic Frameworks*/chemistry , Metal-Organic Frameworks*/pharmacology, Dentin/drug effects ; Sodium Fluoride/pharmacology ; Sodium Fluoride/chemistry ; Quaternary Ammonium Compounds/chemistry ; Quaternary Ammonium Compounds/pharmacology ; Tooth Remineralization/methods ; Fluorides/chemistry ; Animals ; Dogs ; X-Ray Diffraction ; Microscopy, Electron, Scanning ; Silver Compounds ; Humans ; Fluorides, Topical |
| Περίληψη: | This study assessed the remineralization efficacy of a novel agent that contains silver-loaded metal-organic frameworks with fluoride (Ag@MOF/F) on dentin surface of primary teeth. Ag@MOF/F was prepared and characterized by scanning electron microscopy (SEM). The dentin surfaces of 104 sound primary canine were demineralized for 4 days and randomly divided into four groups (n = 26/group): (1) 400 ppm Ag@MOF/F, (2) 1400 ppm Ag@MOF/F, (3) 38% silver diamine fluoride (SDF), and (4) 5% sodium fluoride (NaF). Topographic changes, depth of penetration, and crystal formation were evaluated by SEM, energy-dispersive spectroscopy (EDS), and X-ray diffraction (XRD), respectively. Vickers microhardness and spectrophotometry were used to assess surface hardness and discoloration of the samples. The 1400 ppm Ag@MOF/F group indicated greater depth of penetration and sharper hydroxyapatite peak than the SDF and NaF. The 1400 ppm Ag@MOF/F group had a significantly greater increase in surface and cross-sectional microhardness than the other groups (P < 0.001). The 400 ppm Ag@MOF/F and SDF groups showed similar recovery of microhardness (P = 0.913). SDF-treated specimens were significantly darker than the other groups (P < 0.05), whereas the Ag@MOF/F samples had minimal discoloration. Our results indicate that Ag@MOF/F can be an alternative for SDF in arresting dentin caries because of its enhanced remineralization property and minimal discoloration. (© 2025. The Author(s).) |
| Competing Interests: | Declarations. Competing interests: The authors declare no competing interests. Ethical approval: IR.SUMS.DENTAL.REC.1403.020. |
| References: | Arch Oral Biol. 2022 Jul;139:105434. (PMID: 35525015) J Dent Res. 2018 Jul;97(7):751-758. (PMID: 29768975) Angew Chem Int Ed Engl. 2019 Oct 21;58(43):15188-15205. (PMID: 30977953) J Conserv Dent. 2020 Jan-Feb;23(1):2-9. (PMID: 33223633) J Dent. 2008 Jun;36(6):387-91. (PMID: 18378377) Dent Mater. 2017 Oct;33(10):1110-1126. (PMID: 28779891) Caries Res. 2017;51(5):527-541. (PMID: 28972954) Int J Nanomedicine. 2020 Apr 23;15:2829-2839. (PMID: 32368057) Aust Dent J. 2021 Jun;66(2):188-193. (PMID: 33450061) PLoS One. 2024 Sep 30;19(9):e0308656. (PMID: 39348346) Sci Rep. 2025 Jan 4;15(1):800. (PMID: 39755826) Braz Dent J. 2017 Nov-Dec;28(6):738-743. (PMID: 29211131) J Appl Oral Sci. 2015 Jan-Feb;23(1):14-8. (PMID: 25760263) Polymers (Basel). 2021 Sep 17;13(18):. (PMID: 34578053) PLoS One. 2015 Jan 14;10(1):e0116553. (PMID: 25587986) BMC Oral Health. 2020 Jun 3;20(1):160. (PMID: 32493272) Head Face Med. 2020 Oct 6;16(1):22. (PMID: 33023617) Sci Rep. 2025 Feb 18;15(1):5993. (PMID: 39966489) BMC Oral Health. 2020 Aug 20;20(1):227. (PMID: 32819333) Int J Clin Pediatr Dent. 2022;15(Suppl 2):S247-S251. (PMID: 35645531) J Dent. 2024 Mar;142:104878. (PMID: 38311016) J Dent. 2017 Dec;67S:S11-S14. (PMID: 29233258) Drug Dev Ind Pharm. 2025 Sep;51(9):1016-1029. (PMID: 39101770) J Am Dent Assoc. 2000 May;131(5):589-96. (PMID: 10832252) Int J Dent. 2022 Apr 19;2022:9483589. (PMID: 35497178) Caries Res. 2020;54(2):102-112. (PMID: 31910415) |
| Contributed Indexing: | Keywords: Dental caries; Fluoride; Metal-organic frameworks; Remineralization; Silver diamine fluoride; Silver nanoparticles |
| Substance Nomenclature: | 3M4G523W1G (Silver) 0 (Metal-Organic Frameworks) DDU19UEV1Y (silver diamine fluoride) 8ZYQ1474W7 (Sodium Fluoride) 0 (Quaternary Ammonium Compounds) 0 (Silver Compounds) Q80VPU408O (Fluorides) 0 (Fluorides, Topical) |
| Entry Date(s): | Date Created: 20251212 Date Completed: 20251213 Latest Revision: 20260717 |
| Update Code: | 20260717 |
| PubMed Central ID: | PMC12700857 |
| DOI: | 10.1038/s41598-025-27473-0 |
| PMID: | 41387970 |
| Βάση Δεδομένων: | MEDLINE |
| ISSN: | 2045-2322 |
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| DOI: | 10.1038/s41598-025-27473-0 |