Academic Journal
Προβολή σε EDS
Συνδεδεμένο Πλήρες Κείμενο

Adhesion molecules in the maternal-fetal interface in healthy pregnancies and preeclampsia.

Λεπτομέρειες βιβλιογραφικής εγγραφής
Τίτλος: Adhesion molecules in the maternal-fetal interface in healthy pregnancies and preeclampsia.
Συγγραφείς: Frisch IK; Division of Obstetrics and Gynecology, Department of Obstetrics, Oslo University Hospital Rikshospitalet, Oslo, Norway.; Faculty of Medicine, Institute of Clinical Medicine, University of Oslo, Oslo, Norway., Michelsen TM; Division of Obstetrics and Gynecology, Department of Obstetrics, Oslo University Hospital Rikshospitalet, Oslo, Norway.; Faculty of Medicine, Institute of Clinical Medicine, University of Oslo, Oslo, Norway., Lekva T; Research Institute of Internal Medicine, Oslo University Hospital Rikshospitalet, Oslo, Norway., Roland MCP; Division of Obstetrics and Gynecology, Department of Obstetrics, Oslo University Hospital Rikshospitalet, Oslo, Norway.; Department of Medical Biochemistry, Oslo University Hospital Rikshospitalet, Oslo, Norway., Westerberg AC; Division of Obstetrics and Gynecology, Department of Obstetrics, Oslo University Hospital Rikshospitalet, Oslo, Norway.; School of Health Sciences, Kristiania University College, Oslo, Norway.
Πηγή: Acta obstetricia et gynecologica Scandinavica [Acta Obstet Gynecol Scand] 2026 Feb; Vol. 105 (2), pp. 298-308. Date of Electronic Publication: 2025 Dec 12.
Τύπος έκδοσης: Journal Article
Γλώσσα: English
Στοιχεία περιοδικού: Publisher: Wiley Country of Publication: United States NLM ID: 0370343 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1600-0412 (Electronic) Linking ISSN: 00016349 NLM ISO Abbreviation: Acta Obstet Gynecol Scand Subsets: MEDLINE
Imprint Name(s): Publication: 2011- : Malden, MA : Wiley
Original Publication: Copenhagen : Munksgaard
Ιατρικοί όροι (MeSH): Pre-Eclampsia*/blood , Vascular Cell Adhesion Molecule-1*/blood , Intercellular Adhesion Molecule-1*/blood , E-Selectin*/blood , Placenta*/metabolism , Placenta*/blood supply , Cell Adhesion Molecules*/blood, Biomarkers/blood ; Humans ; Female ; Pregnancy ; Adult ; Case-Control Studies ; Longitudinal Studies
Περίληψη: Introduction: Adhesion molecules are markers of endothelial activation, and they are involved in placentation and inflammation. We compared levels of vascular cell adhesion molecule-1 (VCAM1), intercellular adhesion molecule-1 (ICAM1), and E-selectin (SELE) in maternal and fetal vessels of preeclampsia and healthy pregnancies. Furthermore, we investigated if the placenta releases adhesion molecules.
Material and Methods: Blood was sampled from three maternal (antecubital vein, uterine vein, and radial artery as a proxy for the uterine artery) and two fetal vessels (umbilical vein and artery) in 75 healthy pregnancies and 37 cases of preeclampsia undergoing cesarean delivery. Samples were also collected among 70 healthy pregnancies and 35 preeclampsia cases at three visits (gestational weeks 14-16, 22-24, and 30-32) in a longitudinal cohort. Proteins were relatively quantified on SomaLogic's 5000-multiplex platform. Venoarterial differences on both sides of the placenta were used to indicate placental release and uptake.
Results: Before the onset of preeclampsia, we observed elevated maternal antecubital vein levels of VCAM1 (visits 1 and 3) and ICAM1 (all three visits). At delivery, VCAM1 and SELE were elevated in maternal vessels in preeclampsia compared to healthy, except for VCAM1 in the uterine vein. On the fetal side of the placenta, adhesion molecules were lower in preeclampsia compared to healthy pregnancies. There were no venoarterial differences on the maternal side of the placenta that indicated placental protein release. On the fetal side of the placenta, healthy controls had a positive venoarterial difference of SELE, indicating placental release to the fetus. VCAM1 and SELE levels were higher in fetal circulation as compared to maternal circulation in healthy pregnancies, whereas in preeclampsia, this was only the case for VCAM1. ICAM1 was higher in maternal than fetal circulation in healthy controls and preeclampsia.
Conclusions: Alterations in maternal levels of adhesion molecules were seen before the onset of PE. In preeclampsia, adhesion molecules were elevated in the maternal and lower in the fetal circulation. There was no placental release of the adhesion molecules to the mother, indicating a general systemic endothelial dysfunction. The results highlight new insights into the pathophysiology of preeclampsia that warrant further exploration.
(© 2025 The Author(s). Acta Obstetricia et Gynecologica Scandinavica published by John Wiley & Sons Ltd on behalf of Nordic Federation of Societies of Obstetrics and Gynecology (NFOG).)
References: Eur J Obstet Gynecol Reprod Biol. 1997 Jan;71(1):53-8. (PMID: 9031960)
Am J Obstet Gynecol. 2024 Nov;231(5):550.e1-550.e22. (PMID: 38494070)
Mol Neurobiol. 2021 Jun;58(6):2734-2756. (PMID: 33492643)
Int J Obstet Anesth. 2024 Feb;57:103963. (PMID: 38160194)
N Engl J Med. 2016 Jan 7;374(1):13-22. (PMID: 26735990)
BMC Med. 2022 Jul 1;20(1):227. (PMID: 35773701)
Eur J Obstet Gynecol Reprod Biol. 2008 Apr;137(2):157-64. (PMID: 17706337)
Am J Obstet Gynecol. 2000 Feb;182(2):321-5. (PMID: 10694331)
Front Med (Lausanne). 2020 Jun 12;7:270. (PMID: 32596247)
PLoS One. 2017 Oct 5;12(10):e0185760. (PMID: 28982184)
Metabolites. 2019 May 17;9(5):. (PMID: 31108909)
Placenta. 2019 Nov;87:23-29. (PMID: 31541855)
Int J Mol Sci. 2018 Apr 02;19(4):. (PMID: 29614819)
Am J Obstet Gynecol. 2016 Dec;215(6):782.e1-782.e9. (PMID: 27503620)
Eur J Obstet Gynecol Reprod Biol. 1998 May;78(1):41-5. (PMID: 9605448)
J Obstet Gynaecol Res. 2001 Jun;27(3):147-54. (PMID: 11561831)
N Engl J Med. 2004 Feb 12;350(7):672-83. (PMID: 14764923)
PLoS One. 2012;7(6):e39324. (PMID: 22723995)
J Leukoc Biol. 2013 Feb;93(2):175-84. (PMID: 23233729)
Ultrasound Obstet Gynecol. 2017 Feb;49(2):177-187. (PMID: 28169502)
Am J Obstet Gynecol. 1997 Aug;177(2):443-9. (PMID: 9290466)
FASEB J. 2019 Feb;33(2):2944-2956. (PMID: 30335547)
Hypertension. 2001 Sep;38(3 Pt 2):718-22. (PMID: 11566964)
Pregnancy Hypertens. 2013 Jan;3(1):44-7. (PMID: 26105740)
Clin Exp Obstet Gynecol. 2014;41(6):681-4. (PMID: 25551962)
BJOG. 2001 Dec;108(12):1277-82. (PMID: 11843391)
Amino Acids. 2018 Sep;50(9):1205-1214. (PMID: 29858686)
J Vis Exp. 2017 Aug 2;(126):. (PMID: 28809844)
Immunology. 2014 Nov;143(3):406-15. (PMID: 24831412)
Ann N Y Acad Sci. 1992 Dec 4;667:324-31. (PMID: 1285023)
Am J Reprod Immunol. 1997 Mar;37(3):240-9. (PMID: 9127646)
Glycobiology. 2017 May 1;27(5):385-391. (PMID: 28115423)
PLoS One. 2015 Feb 13;10(2):e0117084. (PMID: 25680194)
Hypertension. 2025 Dec;82(12):2125-2139. (PMID: 41064898)
J Res Med Sci. 2012 Jan;17(1):15-21. (PMID: 23248652)
Am J Reprod Immunol. 2010 Jun;63(6):534-43. (PMID: 20331588)
J Clin Endocrinol Metab. 2019 Mar 1;104(3):873-882. (PMID: 30339207)
J Perinatol. 2020 Nov;40(11):1634-1643. (PMID: 32811975)
Pregnancy Hypertens. 2016 Jan;6(1):47-52. (PMID: 26955772)
J Clin Med Res. 2014 Feb;6(1):1-7. (PMID: 24400024)
Am J Obstet Gynecol. 2024 Apr;230(4):450.e1-450.e18. (PMID: 37806612)
Hypertension. 2001 Sep;38(3):394-8. (PMID: 11566911)
Hypertension. 2006 Jun;47(6):1183-8. (PMID: 16636195)
Basic Clin Pharmacol Toxicol. 2013 Oct;113(4):273-9. (PMID: 23724832)
J Korean Med Sci. 2004 Oct;19(5):688-92. (PMID: 15483345)
J Reprod Immunol. 2019 Sep;134-135:1-10. (PMID: 31301487)
Am J Obstet Gynecol. 2022 Feb;226(2S):S988-S1005. (PMID: 35177225)
Antioxid Redox Signal. 2011 Sep 15;15(6):1607-38. (PMID: 21050132)
Basic Res Cardiol. 2008 Sep;103(5):398-406. (PMID: 18600364)
Circ Res. 2019 Mar 29;124(7):1094-1112. (PMID: 30920918)
Acta Obstet Gynecol Scand. 2026 Feb;105(2):298-308. (PMID: 41387088)
J Obstet Gynaecol Res. 2023 Mar;49(3):870-882. (PMID: 36604828)
Reprod Sci. 2021 Feb;28(2):305-320. (PMID: 33146876)
Drugs. 1998 Dec;56(6):977-88. (PMID: 9878987)
J Matern Fetal Neonatal Med. 2019 Jul;32(13):2113-2136. (PMID: 29320948)
Ultrasound Obstet Gynecol. 2023 Feb;61(2):168-180. (PMID: 35816445)
J Hypertens. 2012 May;30(5):954-9. (PMID: 22441350)
Int J Hypertens. 2019 Sep 17;2019:4108271. (PMID: 31637053)
Clin Chim Acta. 2023 Aug 1;548:117487. (PMID: 37442359)
J Perinatol. 2000 Mar;20(2):114-9. (PMID: 10785888)
Placenta. 2014 Feb;35 Suppl:S20-5. (PMID: 24477207)
Grant Information: 2019095 Helse Sør-Øst RHF; 2018087 Helse Sør-Øst RHF; 300669 Norges Forskningsråd; 271555/F20 Norges Forskningsråd
Contributed Indexing: Keywords: E‐selectin; adhesion molecules; early‐onset preeclampsia; intercellular cell adhesion molecule‐1; late‐onset preeclampsia; placenta; preeclampsia; vascular cell adhesion molecule‐ 1
Substance Nomenclature: 0 (Vascular Cell Adhesion Molecule-1)
126547-89-5 (Intercellular Adhesion Molecule-1)
0 (E-Selectin)
0 (Biomarkers)
0 (Cell Adhesion Molecules)
Entry Date(s): Date Created: 20251212 Date Completed: 20260130 Latest Revision: 20260501
Update Code: 20260502
PubMed Central ID: PMC12856719
DOI: 10.1111/aogs.70111
PMID: 41387088
Βάση Δεδομένων: MEDLINE
Περιγραφή
ISSN:1600-0412
DOI:10.1111/aogs.70111