Academic Journal
Severe myelomeningocele in the fourth pregnancy of a 29-year-old woman: a case report.
| Τίτλος: | Severe myelomeningocele in the fourth pregnancy of a 29-year-old woman: a case report. |
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| Συγγραφείς: | Anghelina L; Department of Medical Informatics and Biostatistics, University of Medicine and Pharmacy of Craiova, Romania; mircea_serbanescu@yahoo.com., Şerbănescu MS, Gheonea C, Anghelina AM, Siminel MA, Camen AR, Dijmărescu AL |
| Πηγή: | Romanian journal of morphology and embryology = Revue roumaine de morphologie et embryologie [Rom J Morphol Embryol] 2025 Jul-Sep; Vol. 66 (3), pp. 587-592. |
| Τύπος έκδοσης: | Journal Article; Case Reports |
| Γλώσσα: | English |
| Στοιχεία περιοδικού: | Publisher: Editura Academiei Române Country of Publication: Romania NLM ID: 9112454 Publication Model: Print Cited Medium: Internet ISSN: 2066-8279 (Electronic) Linking ISSN: 12200522 NLM ISO Abbreviation: Rom J Morphol Embryol Subsets: MEDLINE |
| Imprint Name(s): | Original Publication: Bucuresti, România : Editura Academiei Române, [1990- |
| Ιατρικοί όροι (MeSH): | Meningomyelocele*/pathology , Meningomyelocele*/diagnostic imaging, Humans ; Female ; Adult ; Pregnancy ; Infant, Newborn |
| Περίληψη: | Neural tube defects represent a heterogeneous and complex group of congenital abnormalities affecting the central nervous system. These defects occur during embryogenesis as a result of the failure of the neural tube to close completely. A highly clinically significant form is myelomeningocele, often referred to as open spina bifida or spina bifida aperta. Delayed diagnosis presents considerable challenges, and folate deficiency is an important risk factor. This case reports a severe myelomeningocele located in the lumbosacral region of a female neonate, identified at 28-29 weeks' gestation during the only prenatal consultation of a 29-year-old woman who had three previous normal pregnancies and did not take folic acid (FA) supplementation. The delayed diagnosis contributed to the progression of degenerative and traumatic lesions in the neural tissue, leading to the development of Chiari malformation type II and hydrocephalus. These conditions had a profound impact on brain development, significantly increasing the severity of the case. Primary prevention through the periconceptional use of FA supplements has been shown in extensive research to significantly reduce the probability of neural tube defects, including myelomeningocele. For this reason, FA fortification programs as a public health measure have been implemented in many countries. |
| Competing Interests: | The authors declare that they have no conflict of interests. |
| References: | Br J Nutr. 2016 Mar 28;115(6):974-83. (PMID: 26847388) JAMA. 2009 Feb 11;301(6):636-50. (PMID: 19211471) Hum Mol Genet. 2008 Dec 1;17(23):3675-85. (PMID: 18753144) Birth Defects Res. 2019 Nov 15;111(19):1455-1467. (PMID: 30421543) Prenat Diagn. 1989 Dec;9(12):813-29. (PMID: 2483269) Indian J Public Health. 2014 Jan-Mar;58(1):54-6. (PMID: 24748359) Pediatr Rep. 2013 Feb 05;5(1):e5. (PMID: 23667734) Ann Epidemiol. 2011 Nov;21(11):842-50. (PMID: 21982488) Paediatr Perinat Epidemiol. 2009 Mar;23(2):116-24. (PMID: 19159398) Pediatr Nephrol. 2008 Aug;23(8):1223-31. (PMID: 18200450) Pediatrics. 2009 Mar;123(3):917-23. (PMID: 19255021) Birth Defects Res A Clin Mol Teratol. 2011 Nov;91(11):962-5. (PMID: 21956977) J Obstet Gynaecol Can. 2014 Oct;36(10):927-939. (PMID: 25375307) Annu Rev Neurosci. 2014;37:221-42. (PMID: 25032496) Ann Nutr Metab. 2011 Oct;58(4):263-71. (PMID: 21865678) Cochrane Database Syst Rev. 2015 Dec 14;(12):CD007950. (PMID: 26662928) J Pathol. 2010 Jan;220(2):217-30. (PMID: 19918803) Childs Nerv Syst. 2020 Jul;36(7):1507-1513. (PMID: 31664560) MMWR Morb Mortal Wkly Rep. 2015 Jan 16;64(1):1-5. (PMID: 25590678) Neurotoxicol Teratol. 2005 May-Jun;27(3):515-24. (PMID: 15939212) Biomed Res Int. 2016;2016:6382825. (PMID: 27999804) Nat Rev Dis Primers. 2015 Apr 30;1:15007. (PMID: 27189655) BMC Pregnancy Childbirth. 2021 Jun 14;21(1):426. (PMID: 34126936) Open Life Sci. 2022 Dec 22;17(1):1679-1688. (PMID: 36589786) Am J Clin Nutr. 2007 Jan;85(1):285S-288S. (PMID: 17209211) Ann Plast Surg. 1993 Dec;31(6):514-21. (PMID: 8297082) Lancet. 1977 Jun 25;1(8026):1323-32. (PMID: 69055) J Clin Med. 2024 Jan 14;13(2):. (PMID: 38256600) Am J Prev Med. 2016 May;50(5 Suppl 1):S74-S80. (PMID: 26790341) Am J Obstet Gynecol. 1998 Jul;179(1):235-40. (PMID: 9704793) World J Orthop. 2016 Jul 18;7(7):406-17. (PMID: 27458551) Birth Defects Res. 2020 Jan 15;112(2):186-195. (PMID: 31774241) N Engl J Med. 2011 Mar 17;364(11):993-1004. (PMID: 21306277) Lancet. 1991 Jul 20;338(8760):131-7. (PMID: 1677062) Pediatr Neurosurg. 2003 Mar;38(3):133-45. (PMID: 12601238) Front Pediatr. 2023 May 22;11:1126209. (PMID: 37284286) Birth Defects Res. 2019 Nov 15;111(19):1564-1576. (PMID: 31576681) Arch Argent Pediatr. 2021 Jun;119(3):e215-e228. (PMID: 34033426) |
| Contributed Indexing: | Keywords: Chiari malformation type II; case report; folic acid supplementation; hydrocephalus; myelomeningocele |
| Entry Date(s): | Date Created: 20251212 Date Completed: 20251212 Latest Revision: 20260126 |
| Update Code: | 20260130 |
| PubMed Central ID: | PMC12831564 |
| DOI: | 10.47162/RJME.66.3.16 |
| PMID: | 41382955 |
| Βάση Δεδομένων: | MEDLINE |
| ISSN: | 2066-8279 |
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| DOI: | 10.47162/RJME.66.3.16 |