Very Long-Term Follow-Up of Multidimensional Health-Related Quality of Life After Endoscopic Endonasal Surgery for Pituitary Adenomas: A Prospective Cohort Study.

Λεπτομέρειες βιβλιογραφικής εγγραφής
Τίτλος:	Very Long-Term Follow-Up of Multidimensional Health-Related Quality of Life After Endoscopic Endonasal Surgery for Pituitary Adenomas: A Prospective Cohort Study.
Συγγραφείς:	Joustra GE; Department of Otorhinolaryngology-Head and Neck Surgery, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands.; Graduate School of Medical Sciences, University of Groningen, Groningen, the Netherlands., van Rhee NF; Department of Otorhinolaryngology-Head and Neck Surgery, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands., den Heijer MC; Department of Otorhinolaryngology-Head and Neck Surgery, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands.; Graduate School of Medical Sciences, University of Groningen, Groningen, the Netherlands., Korsten-Meijer AGW; Department of Otorhinolaryngology-Head and Neck Surgery, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands., Feijen RA; Department of Otorhinolaryngology-Head and Neck Surgery, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands., Halmos GB; Department of Otorhinolaryngology-Head and Neck Surgery, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands., Kuijlen JMA; Department of Neurosurgery, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands., Vermeulen KM; Department of Epidemiology, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands.
Πηγή:	Head & neck [Head Neck] 2026 Apr; Vol. 48 (4), pp. 1088-1096. Date of Electronic Publication: 2025 Nov 28.
Τύπος έκδοσης:	Journal Article
Γλώσσα:	English
Στοιχεία περιοδικού:	Publisher: John Wiley And Sons Country of Publication: United States NLM ID: 8902541 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1097-0347 (Electronic) Linking ISSN: 10433074 NLM ISO Abbreviation: Head Neck Subsets: MEDLINE
Imprint Name(s):	Publication: New York, NY : John Wiley And Sons Original Publication: New York, NY : J. Wiley, c1989-
Ιατρικοί όροι (MeSH):	Pituitary Neoplasms/surgery , Pituitary Neoplasms/psychology , Adenoma/surgery , Adenoma/psychology , Endoscopy/methods , Quality of Life, Humans ; Female ; Male ; Middle Aged ; Prospective Studies ; Follow-Up Studies ; Adult ; Aged ; Surveys and Questionnaires ; Treatment Outcome ; Time Factors
Περίληψη:	Background: To evaluate postoperative health-related quality of life (HRQoL) for pituitary adenoma patients, multidimensional assessment is important. Available data is limited on long-term follow-up. Methods: Prospectively, 52 nonfunctioning (NFA) and functioning (FA) pituitary adenoma patients were included. The Endoscopic Endonasal Sinus and Skull Base Surgery Questionnaire (EES-Q) was completed preoperatively and postoperatively (2 weeks, 3 months, 1 year, 8.5 years). Generalized estimating equations identified variables associated with HRQoL changes over time. Results: Psychological (p = 0.006) and social HRQoL (p = 0.026) significantly improved after very long-term follow-up, while physical HRQoL and EES-Q scores normalized. Pre- and postoperatively, most inconveniences were reported in the social domain, with a noticeable difference between NFA and FA patients. Female gender negatively impacted physical HRQoL. Conclusions: Endoscopic endonasal surgery has no very long-term negative impact on HRQoL. Social functioning remained the most affected throughout follow-up. These results highlight the importance of this multidimensional HRQoL tool to improve patient-centered health care. (© 2025 The Author(s). Head & Neck published by Wiley Periodicals LLC.)
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Contributed Indexing:	Keywords: Endoscopic Endonasal Sinus and Skull Base Surgery Questionnaire (EES‐Q); anterior skull base; endoscopic skull base surgery; patient‐reported outcome measure; pituitary adenoma
Entry Date(s):	Date Created: 20251128 Date Completed: 20260310 Latest Revision: 20260813
Update Code:	20260813
PubMed Central ID:	PMC12972636
DOI:	10.1002/hed.70103
PMID:	41312616
Βάση Δεδομένων:	MEDLINE

Περιγραφή
ISSN:	1097-0347
DOI:	10.1002/hed.70103