Academic Journal
NT-proBNP and its correlation to left ventricular ejection fraction and heart failure - The DEMONSTRATE database.
| Τίτλος: | NT-proBNP and its correlation to left ventricular ejection fraction and heart failure - The DEMONSTRATE database. |
|---|---|
| Συγγραφείς: | Lundgren M; Department of Medical Sciences, Clinical Chemistry, Uppsala University, Uppsala, Sweden., Ridefelt P; Department of Medical Sciences, Clinical Chemistry, Uppsala University, Uppsala, Sweden., Svensson MK; Department of Medical Sciences, Renal Medicine, Uppsala University, Uppsala, Sweden.; Uppsala Clinical Research Centre, Uppsala, Sweden., Hagström E; Department of Medical Sciences, Cardiology, Uppsala University, Uppsala, Sweden., Cars T; Sence Research AB, Uppsala, Sweden., Larsson A; Department of Medical Sciences, Clinical Chemistry, Uppsala University, Uppsala, Sweden. |
| Πηγή: | Annals of clinical biochemistry [Ann Clin Biochem] 2026 Jul; Vol. 63 (4), pp. 308-318. Date of Electronic Publication: 2025 Nov 17. |
| Τύπος έκδοσης: | Journal Article |
| Γλώσσα: | English |
| Στοιχεία περιοδικού: | Publisher: Sage Country of Publication: England NLM ID: 0324055 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1758-1001 (Electronic) Linking ISSN: 00045632 NLM ISO Abbreviation: Ann Clin Biochem Subsets: MEDLINE |
| Imprint Name(s): | Publication: Jan. 2013- : London : Sage Original Publication: London, Association of Clinical Biochemists. |
| Ιατρικοί όροι (MeSH): | Natriuretic Peptide, Brain*/blood , Heart Failure*/blood , Heart Failure*/physiopathology , Heart Failure*/diagnosis , Peptide Fragments*/blood , Stroke Volume* , Ventricular Function, Left*, Biomarkers/blood ; Humans ; Female ; Aged ; Male ; Middle Aged ; Databases, Factual ; Sweden |
| Περίληψη: | BackgroundMeasurement of N-terminal pro-B-type natriuretic peptide (NT-proBNP) and left ventricular ejection fraction (LVEF) are used in diagnosing heart failure (HF). The main aim was to explore the correlation between NT-proBNP and LVEF.MethodsPatient data for 14,962 patients were extracted from medical records and national registries and compiled in the Swedish DEMONSTRATE database. HF phenotype was categorized according to LVEF level: HF with reduced EF (≤40%, HFrEF); HF with mildly reduced EF (41-49%, HFmrEF); HF with preserved EF (≥50%, HFpEF). Spearman's rank was employed for correlation analysis and ROC curves for discrimination and classification.ResultsNT-proBNP correlated negatively with LVEF level (r = -0.40) and positively with age (r = 0.49), creatinine (r = 0.35), and cystatin C (r = 0.53). Individuals with an HF diagnosis were more likely to have higher NT-proBNP levels compared to those without. The association between NT-proBNP and LVEF remained statistically significant (P < .0001) also after adjusting for age and kidney function estimates (r = -0.20). NT-proBNP discriminated well between HFrEF (AUC = 0.80) and HFpEF (AUC = 0.78). In discriminating the presence of an HF diagnosis, NT-proBNP (AUC = 0.81) outperformed LVEF (AUC = 0.75). However, on an individual level the correlation between LVEF and NT-proBNP was modest.ConclusionsNT-proBNP levels increase when LVEF deteriorates but with large inter-individual differences. Further research is needed, but these findings show potential in optimizing the use of LVEF with the aid of sequential analysis of NT-proBNP as a complementary diagnostic and prognostic tool to enhance assessment of cardiac function. |
| Competing Interests: | Declaration of conflicting interestsThe authors declared the following potential conflicts of interest with respect to the research, authorship, and/or publication of this article: Thomas Cars is an employee and shareholder of Sence Research AB, a company in epidemiology and biostatistics, providing services to both public and private sector clients. Apart from this, the authors declare that they have no competing interests or conflict of interest related to the current manuscript. All authors fulfil the ICMJE requirements for authorship. |
| Contributed Indexing: | Keywords: Brain natriuretic peptide; coronary disease; echocardiography; heart failure; left ventricular ejection fraction |
| Substance Nomenclature: | 114471-18-0 (Natriuretic Peptide, Brain) 0 (Peptide Fragments) 0 (pro-brain natriuretic peptide (1-76)) 0 (Biomarkers) |
| Entry Date(s): | Date Created: 20251117 Date Completed: 20260704 Latest Revision: 20260726 |
| Update Code: | 20260726 |
| PubMed Central ID: | PMC13332166 |
| DOI: | 10.1177/00045632251403397 |
| PMID: | 41247830 |
| Βάση Δεδομένων: | MEDLINE |
| ISSN: | 1758-1001 |
|---|---|
| DOI: | 10.1177/00045632251403397 |