Academic Journal
Phytochemical Profiling and In Vitro Evaluation of Antioxidant, Antimicrobial, Hypoglycemic, and Antiulcer Activities of Aerial Parts of Rumex hastatus D. Don.
| Τίτλος: | Phytochemical Profiling and In Vitro Evaluation of Antioxidant, Antimicrobial, Hypoglycemic, and Antiulcer Activities of Aerial Parts of Rumex hastatus D. Don. |
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| Συγγραφείς: | Sharma P; Department of Biosciences, Himachal Pradesh University, Shimla, India., Guleria D; Department of Biosciences, Himachal Pradesh University, Shimla, India., Dhiman S; Department of Biosciences, Himachal Pradesh University, Shimla, India., Sehgal AK; Department of Biosciences, Himachal Pradesh University, Shimla, India. |
| Πηγή: | Chemistry & biodiversity [Chem Biodivers] 2026 Jan; Vol. 23 (1), pp. e02151. Date of Electronic Publication: 2025 Nov 15. |
| Τύπος έκδοσης: | Journal Article |
| Γλώσσα: | English |
| Στοιχεία περιοδικού: | Publisher: Verlag Helvetica Chimica Acta Country of Publication: Switzerland NLM ID: 101197449 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1612-1880 (Electronic) Linking ISSN: 16121872 NLM ISO Abbreviation: Chem Biodivers Subsets: MEDLINE |
| Imprint Name(s): | Original Publication: Zürich, Switzerland : Hoboken, NJ : Verlag Helvetica Chimica Acta ; Distributed in the USA by Wiley, c2004- |
| Ιατρικοί όροι (MeSH): | Antioxidants*/pharmacology , Antioxidants*/chemistry , Antioxidants*/isolation & purification , Plant Components, Aerial*/chemistry , Plant Components, Aerial*/metabolism , Hypoglycemic Agents*/pharmacology , Hypoglycemic Agents*/chemistry , Hypoglycemic Agents*/isolation & purification , Phytochemicals*/pharmacology , Phytochemicals*/chemistry , Phytochemicals*/isolation & purification , Rumex*/chemistry , Anti-Infective Agents*/pharmacology , Anti-Infective Agents*/chemistry , Anti-Infective Agents*/isolation & purification , Plant Extracts*/chemistry , Plant Extracts*/pharmacology , Plant Extracts*/isolation & purification , Anti-Bacterial Agents*/pharmacology , Anti-Bacterial Agents*/chemistry , Anti-Bacterial Agents*/isolation & purification, alpha-Amylases/antagonists & inhibitors ; alpha-Amylases/metabolism ; Picrates/antagonists & inhibitors ; Urease/antagonists & inhibitors ; Urease/metabolism ; Biphenyl Compounds/antagonists & inhibitors ; Enzyme Inhibitors/chemistry ; Enzyme Inhibitors/pharmacology ; Enzyme Inhibitors/isolation & purification ; Microbial Sensitivity Tests |
| Περίληψη: | The present study investigated the phytochemical profiling, antioxidant, antimicrobial, hypoglycemic, and antiulcer activities of acetone, methanol, and petroleum ether extracts of aerial parts of Rumex hastatus. The antioxidant activity was examined through two techniques: the DPPH assay and the reducing power assay (RPA). The phytochemical constituents were studied by qualitative analysis (preliminary, GC-MS, HPLC) and quantitative analysis (spectrophotometry). The extracts were tested for hypoglycemic (anti-α-amylase) and antiulcer (anti-urease) activities through enzyme inhibition assays. To determine antimicrobial activity, a disk diffusion assay and a broth microdilution method were used. All the extracts were discovered to contain alkaloids, flavonoids, tannins, terpenoids, carbohydrates, and proteins. Saponins were only present in the methanol extract. HPLC analysis identified catechin, quercetin, gallic acid, and ascorbic acid in R. hastatus extracts. The findings revealed that the methanol extract exhibited the highest total flavonoid content (TFC) and total tannin content (TTC), and confirmed significant antioxidant activity in both DPPH and RPA assays. In addition, the methanol extract showed the greatest inhibition of both the enzymes α-amylase and urease as compared to the other extracts. All extracts showed potent antimicrobial activity against various tested microbes using both the disk diffusion method and the resazurin broth microdilution method. (© 2025 Wiley‐VHCA AG, Zurich, Switzerland.) |
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| Contributed Indexing: | Keywords: DPPH; GC–MS; biological activity; phytochemistry; α‐amylase |
| Substance Nomenclature: | 0 (Antioxidants) 0 (Hypoglycemic Agents) 0 (Phytochemicals) EC 3.2.1.1 (alpha-Amylases) 0 (Anti-Infective Agents) 0 (Plant Extracts) 0 (Picrates) EC 3.5.1.5 (Urease) 0 (Biphenyl Compounds) DFD3H4VGDH (1,1-diphenyl-2-picrylhydrazyl) 0 (Anti-Bacterial Agents) 0 (Enzyme Inhibitors) |
| Entry Date(s): | Date Created: 20251115 Date Completed: 20260103 Latest Revision: 20260813 |
| Update Code: | 20260813 |
| PubMed Central ID: | PMC13420631 |
| DOI: | 10.1002/cbdv.202502151 |
| PMID: | 41240332 |
| Βάση Δεδομένων: | MEDLINE |
| ISSN: | 1612-1880 |
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| DOI: | 10.1002/cbdv.202502151 |