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A Tracked High-Resolution Ultrasound Endoscope for Minimally Invasive Brain Surgery.

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Τίτλος: A Tracked High-Resolution Ultrasound Endoscope for Minimally Invasive Brain Surgery.
Συγγραφείς: Benson A; School of Biomedical Engineering, Dalhousie University, Halifax , Nova Scotia , Canada., Weaver R; School of Biomedical Engineering, Dalhousie University, Halifax , Nova Scotia , Canada., Weeks A; Division of Neurosurgery, Nova Scotia Health, Halifax , Nova Scotia , Canada., Hayes T; Synaptive Medical, Toronto , Ontario , Canada., Richmond J; Synaptive Medical, Toronto , Ontario , Canada., Landry T; School of Biomedical Engineering, Dalhousie University, Halifax , Nova Scotia , Canada., Brown J; School of Biomedical Engineering, Dalhousie University, Halifax , Nova Scotia , Canada.
Πηγή: Operative neurosurgery (Hagerstown, Md.) [Oper Neurosurg] 2026 Aug 01; Vol. 31 (2), pp. 361-371. Date of Electronic Publication: 2025 Oct 28.
Τύπος έκδοσης: Journal Article
Γλώσσα: English
Στοιχεία περιοδικού: Publisher: Lippincott Williams & Wilkins, Inc Country of Publication: United States NLM ID: 101635417 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2332-4260 (Electronic) Linking ISSN: 23324252 NLM ISO Abbreviation: Oper Neurosurg Subsets: MEDLINE
Imprint Name(s): Publication: 2022- : [Philadelphia] : Lippincott Williams & Wilkins, Inc.
Original Publication: Hagerstown, MD: Lippincott, Williams & Wilkins, 2014-
Ιατρικοί όροι (MeSH): Brain Neoplasms*/surgery , Brain Neoplasms*/diagnostic imaging , Minimally Invasive Surgical Procedures*/methods , Minimally Invasive Surgical Procedures*/instrumentation , Neuronavigation*/methods , Neuronavigation*/instrumentation , Neurosurgical Procedures*/methods , Neurosurgical Procedures*/instrumentation , Glioblastoma*/surgery , Glioblastoma*/diagnostic imaging , Brain*/surgery , Brain*/diagnostic imaging, Intracranial Aneurysm/surgery ; Intracranial Aneurysm/diagnostic imaging ; Humans ; Phantoms, Imaging ; Equipment Design
Περίληψη: Background and Objectives: We have developed a novel intraoperative imaging adjunct to address limitations in neurosurgical guidance technology: a miniature, high-resolution, tracked ultrasound (US) imaging endoscope. This report describes the fabrication and preliminary testing of the device, which aims to enhance neurosurgery by providing precise, real-time visualization of the brain within narrow surgical pathways.
Methods: The work has 2 components: (1) the development and clinical validation of the US endoscope and (2) its integration with a surgical navigation system (SNS), with tracking validated in a brain phantom. A miniature (3.8 × 4 mm cross-section) 30 MHz phased array with 64 elements was developed, and probe performance and safety were tested. Investigational testing of the untracked imaging probe was performed in 3 adult neurosurgery cases (2 glioblastoma resections and 1 aneurysm clipping). B-mode and Doppler imaging data were collected to explore the probe's ability to visualize anatomy intraoperatively. The probe was integrated with a commercial SNS and tested in a brain phantom containing a simulated tumor and landmark. Agreement between the landmark location based on B-mode US and navigated 3-dimensional T1-weighted MRI was characterized.
Results: The probe demonstrated axial and lateral resolutions of 38 and 113 µm, respectively. During tumor resection, it differentiated tumor from healthy tissue and identified residual tumor missed by conventional surgical guidance. Key structures were also visualized during aneurysm surgery. The US probe was successfully integrated with a SNS. When this combined system was tested in a brain phantom, there was good agreement between tumor boundaries in navigated MRI and US images, with the apparent landmark location agreeing within µ = 2.90 mm over 25 trials.
Conclusion: This first-of-its-kind imaging system shows potential as a novel adjunct for neurosurgical guidance. Further clinical testing is needed to fully validate its efficacy.
(Copyright © Congress of Neurological Surgeons 2025. All rights reserved.)
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Grant Information: 1027846 Nova Scotia Health Authority; 193258 Canada CAPMC CIHR; 525324 Natural Sciences and Engineering Research Council of Canada
Contributed Indexing: Keywords: Aneurysm; Glioblastoma; High resolution; Minimally invasive surgery; Surgical navigation; Tumor; Ultrasound
Entry Date(s): Date Created: 20251105 Date Completed: 20260715 Latest Revision: 20260717
Update Code: 20260717
DOI: 10.1227/ons.0000000000001812
PMID: 41191786
Βάση Δεδομένων: MEDLINE
Περιγραφή
ISSN:2332-4260
DOI:10.1227/ons.0000000000001812