Academic Journal
Advances Focusing on the Application of Various Ions in Tendon-Bone Healing.
| Τίτλος: | Advances Focusing on the Application of Various Ions in Tendon-Bone Healing. |
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| Συγγραφείς: | Yu P; Hengyang Medical School, University of South China, Hengyang, China., Guo J; Hengyang Medical School, University of South China, Hengyang, China., Nie G; Hengyang Medical School, University of South China, Hengyang, China., He Y; Hengyang Medical School, University of South China, Hengyang, China., Peng T; Hengyang Medical School, University of South China, Hengyang, China., Chen X; Hengyang Medical School, University of South China, Hengyang, China., Li L; Hengyang Medical School, University of South China, Hengyang, China., Dai Z; Department of Orthopedics, Hengyang Medical School, The First Affiliated Hospital of University of South China, Hengyang, China., Xie W; Hengyang Medical School, University of South China, Hengyang, China. |
| Πηγή: | Tissue engineering. Part B, Reviews [Tissue Eng Part B Rev] 2026 Oct; Vol. 32 (5), pp. 359-368. Date of Electronic Publication: 2025 Oct 24. |
| Τύπος έκδοσης: | Journal Article; Review |
| Γλώσσα: | English |
| Στοιχεία περιοδικού: | Publisher: Mary Ann Liebert, Inc Country of Publication: United States NLM ID: 101466660 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1937-3376 (Electronic) Linking ISSN: 19373368 NLM ISO Abbreviation: Tissue Eng Part B Rev Subsets: MEDLINE |
| Imprint Name(s): | Original Publication: New Rochelle, NY : Mary Ann Liebert, Inc. |
| Ιατρικοί όροι (MeSH): | Bone and Bones*/pathology , Wound Healing*/drug effects , Tendons*/pathology , Metals*/pharmacology , Ions*, Humans ; Animals ; Biocompatible Materials |
| Περίληψη: | The tendon-bone interface (TBI) possesses a highly intricate structure, making complete restoration of its native structure postinjury particularly challenging, which often leads to suboptimal healing outcomes. Metal ions, such as calcium (Ca2+), magnesium (Mg2+), zinc (Zn2+), copper (Cu2+), cobalt (Co2+), strontium (Sr2+), iron (Fe2+/Fe3+), and lithium (Li+), have attached significant attention in tissue regeneration research owing to the excellent roles in promoting angiogenesis, osteogenesis, and chondrogenesis. This review systematically elucidates a comprehensive overview of the current understanding of these bioactive ions' mechanisms and their applications in TBI repair. Additionally, the review highlights the importance of incorporating metal ions into biomaterial scaffolds to enhance simultaneous multitissue regeneration while addressing current therapeutic limitations in TBI management. Finally, the review outlines future research directions for optimizing ion-based biomaterial strategies to advance TBI treatment paradigms. |
| Competing Interests: | Author Disclosure StatementNo competing financial interests exist. |
| Contributed Indexing: | Keywords: biomaterials; healing; mental ions; tendon–bone interface |
| Substance Nomenclature: | 0 (Ions) 0 (Metals) 0 (Biocompatible Materials) |
| Entry Date(s): | Date Created: 20251105 Date Completed: 20260824 Latest Revision: 20260824 |
| Update Code: | 20260824 |
| DOI: | 10.1177/19373368251388823 |
| PMID: | 41189409 |
| Βάση Δεδομένων: | MEDLINE |
| ISSN: | 1937-3376 |
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| DOI: | 10.1177/19373368251388823 |