Academic Journal
Assessing Pelvic Organ Prolapse Volume in Patients with Rectal Prolapse via MRI.
| Τίτλος: | Assessing Pelvic Organ Prolapse Volume in Patients with Rectal Prolapse via MRI. |
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| Συγγραφείς: | Khorsandi S; Urogynecology, Stanford University Hospital, Stanford, CA, USA. shayan.drk@gmail.com.; 16 Plaza Santa Cruz, Antillana-Encantada, Trujillo Alto, PR, 00976, USA. shayan.drk@gmail.com., Sheth VR; Radiology, Stanford University Hospital, Stanford, CA, USA., Chow A; Urogynecology, Stanford University Hospital, Stanford, CA, USA., Liang T; Statistics, Stanford University, Stanford, CA, USA., Gurland B; Colorectal Surgery, Stanford University Hospital, Stanford, CA, USA., Sokol ER; Urogynecology, Stanford University School of Medicine, Stanford, CA, USA. |
| Πηγή: | International urogynecology journal [Int Urogynecol J] 2026 Apr; Vol. 37 (4), pp. 893-901. Date of Electronic Publication: 2025 Oct 28. |
| Τύπος έκδοσης: | Journal Article |
| Γλώσσα: | English |
| Στοιχεία περιοδικού: | Publisher: Springer Country of Publication: England NLM ID: 101567041 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1433-3023 (Electronic) Linking ISSN: 09373462 NLM ISO Abbreviation: Int Urogynecol J Subsets: MEDLINE |
| Imprint Name(s): | Original Publication: London : Springer |
| Ιατρικοί όροι (MeSH): | Magnetic Resonance Imaging*/methods , Rectal Prolapse*/diagnostic imaging , Rectal Prolapse*/complications , Rectal Prolapse*/pathology , Defecography*/methods , Pelvic Organ Prolapse*/diagnostic imaging , Pelvic Organ Prolapse*/pathology, Pelvic Floor/diagnostic imaging ; Humans ; Female ; Retrospective Studies ; Middle Aged ; Aged ; Severity of Illness Index |
| Περίληψη: | Introduction and Hypothesis: The utility of magnetic resonance imaging (MRI) in recognizing the severity of pelvic organ prolapse (POP) in patients with rectal prolapse (RP) remains underexplored. Understanding POP volume in these patients may be crucial for targeted interventions, particularly in RP cases where a multidisciplinary approach is often required. This study investigates whether volume measurements via MRI defecography can improve screening for symptomatic POP and provide better guidance for clinical interventions. Methods: This retrospective cohort study involved 77 women with RP who underwent MRI defecography at a university hospital from 2017 to 2022. Estimated levator ani subtended volume (eLASV) was calculated both at rest (eLASV-R) and during strain (eLASV-S), with multivariable regression analysis used to compare these measures. Youden's index identified optimal cutoff values for high and low volumetric POP. Results: Measurements of eLASV-S were predictive of symptomatic POP. The optimal cutoff for eLASV-S was 102.5 cm3, significantly associated with the need for surgical interventions. eLASV-S provided clearer differentiation between symptomatic and asymptomatic patients than eLASV-R. Conclusions: Magnetic resonance imaging defecography, particularly eLASV-S measurements, appears valuable for identifying high-volume POP in patients with RP. The finding of a significant eLASV-S cutoff suggests that MRI volume assessments could assist in guiding clinical decisions. Prospective studies are recommended to further validate these results and explore the full diagnostic potential of MRI. (© 2025. The Author(s), under exclusive license to International Urogynecological Association.) |
| Competing Interests: | Declarations. Ethical Approval: This study was approved by the Stanford University Institutional Review Board (IRB# 54321). Given the retrospective design, the requirement for informed consent was waived. The study was conducted in accordance with the ethical principles outlined in the Declaration of Helsinki. Conflicts of Interest: None. |
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| Contributed Indexing: | Keywords: MR defecography; Pelvic organ prolapse symptom predictability; Pelvic organ prolapse volume; Rectal prolapse; eLASV |
| Entry Date(s): | Date Created: 20251028 Date Completed: 20260416 Latest Revision: 20261010 |
| Update Code: | 20261010 |
| DOI: | 10.1007/s00192-025-06297-6 |
| PMID: | 41148314 |
| Βάση Δεδομένων: | MEDLINE |
| ISSN: | 1433-3023 |
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| DOI: | 10.1007/s00192-025-06297-6 |