Academic Journal
The role of m6A reader IGF2BPs in tumor metabolic reprogramming.
| Title: | The role of m6A reader IGF2BPs in tumor metabolic reprogramming. |
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| Authors: | Zhou X; The Affiliated Nanhua Hospital, Department of Clinical Laboratory, Hengyang Medical School, University of South China, Hengyang, Hunan 421001, China., Li G; Institute of Cardiovascular Disease, Key Laboratory for Arteriosclerology of Hunan Province, Hunan International Scientific and Technological Cooperation Base of Arteriosclerotic Disease, Department of Pathophysiology, School of Basic Medical Sciences, Hengyang Medical School, University of South China, Hengyang, Hunan 421001, China., Su X; The Affiliated Nanhua Hospital, Department of Clinical Laboratory, Hengyang Medical School, University of South China, Hengyang, Hunan 421001, China., Wang Y; The Affiliated Nanhua Hospital, Department of Clinical Laboratory, Hengyang Medical School, University of South China, Hengyang, Hunan 421001, China., Liu L; Hunan Province Key Laboratory of Basic and Applied Hematology, Molecular Biology Research Center & Center for Medical Genetics, School of Life Sciences, Central South University, Changsha 410078 Hunan, China., Yang C; Hunan Province Key Laboratory of Basic and Applied Hematology, Molecular Biology Research Center & Center for Medical Genetics, School of Life Sciences, Central South University, Changsha 410078 Hunan, China., Xu Y; The Affiliated Nanhua Hospital, Department of Clinical Laboratory, Hengyang Medical School, University of South China, Hengyang, Hunan 421001, China., He J; The Affiliated Nanhua Hospital, Department of Hepatobiliary Surgery, Hengyang Medical School, University of South China, Hengyang, Hunan 421001, China. Electronic address: 1684131533@qq.com., Zhang J; The Affiliated Nanhua Hospital, Department of Clinical Laboratory, Hengyang Medical School, University of South China, Hengyang, Hunan 421001, China. Electronic address: zhang_ji001@hotmail.com. |
| Source: | Biochemical pharmacology [Biochem Pharmacol] 2026 Jan; Vol. 243 (Pt 1), pp. 117452. Date of Electronic Publication: 2025 Oct 24. |
| Publication Type: | Journal Article; Review; Research Support, Non-U.S. Gov't |
| Language: | English |
| Journal Info: | Publisher: Elsevier Science Country of Publication: England NLM ID: 0101032 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-2968 (Electronic) Linking ISSN: 00062952 NLM ISO Abbreviation: Biochem Pharmacol Subsets: MEDLINE |
| Imprint Name(s): | Publication: Oxford : Elsevier Science Original Publication: Oxford, New York [etc.] Paragamon Press. |
| MeSH Terms: | Neoplasms*/metabolism , Neoplasms*/genetics , RNA-Binding Proteins*/metabolism , RNA-Binding Proteins*/genetics , Adenosine*/analogs & derivatives , Adenosine*/metabolism , Cellular Reprogramming*/physiology, Lipid Metabolism/physiology ; Glycolysis/physiology ; Insulin-Like Growth Factor II/metabolism ; Humans ; Animals ; Metabolic Reprogramming |
| Abstract: | Insulin-like growth factor II mRNA-binding proteins (IGF2BPs) regulate the metabolic reprogramming of tumor cells via N6-methyladenosine (m6A) modification, promoting rapid proliferation and malignant progression. The RNAs of key metabolic enzymes are regulated by IGF2BPs through diverse mechanisms in critical pathways, including aerobic glycolysis, lipid metabolism, and amino acid metabolism. However, the specific molecular mechanisms involved in cancer metabolism have not been fully elucidated. This review systematically summarizes the pivotal regulator of IGF2BPs in tumor metabolism, including aerobic glycolysis, lipid metabolism and amino acid metabolism, which explores the biological functions and potential therapeutic targets of IGF2BPs in various tumors. Herein, targeting the regulation of IGF2BPs activity in the regulation of cell metabolism is highly beneficial in the diagnosis and treatment of various tumors. (Copyright © 2025 Elsevier Inc. All rights reserved.) |
| Competing Interests: | Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. |
| Contributed Indexing: | Keywords: Aerobic glycolysis; Amino acid metabolism; IGF2BPs; Lipid metabolism; Metabolic reprogramming; m6A modification |
| Substance Nomenclature: | 0 (RNA-Binding Proteins) K72T3FS567 (Adenosine) CLE6G00625 (N-methyladenosine) 67763-97-7 (Insulin-Like Growth Factor II) |
| Entry Date(s): | Date Created: 20251025 Date Completed: 20251206 Latest Revision: 20260603 |
| Update Code: | 20260604 |
| DOI: | 10.1016/j.bcp.2025.117452 |
| PMID: | 41138927 |
| Database: | MEDLINE |
| ISSN: | 1873-2968 |
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| DOI: | 10.1016/j.bcp.2025.117452 |