Academic Journal
Assessing rapid response mobile laboratory (RRML) capacities in Europe and Africa to improve One Health disease surveillance activities and pandemic preparedness across two continents.
| Τίτλος: | Assessing rapid response mobile laboratory (RRML) capacities in Europe and Africa to improve One Health disease surveillance activities and pandemic preparedness across two continents. |
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| Συγγραφείς: | Trojnacki A; Bernhard-Nocht-Institute for Tropical Medicine (BNITM), Hamburg, Germany., Nguinkal JA; Bernhard-Nocht-Institute for Tropical Medicine (BNITM), Hamburg, Germany., May J; Bernhard-Nocht-Institute for Tropical Medicine (BNITM), Hamburg, Germany.; German Center for Infection Research (DZIF), Partner Site Hamburg- Lübeck-Borstel-Riems, Hamburg, Germany.; Tropical Medicine II, University Medical Center Hamburg-Eppendorf (UKE), Hamburg, Germany., Rainer K; Österreichische Agentur für Gesundheit und Ernährungssicherheit (AGES), Vienna, Austria., Duscher GG; Österreichische Agentur für Gesundheit und Ernährungssicherheit (AGES), Vienna, Austria., Winkelmayer L; Österreichische Agentur für Gesundheit und Ernährungssicherheit (AGES), Vienna, Austria., Ungureanu A; Red Cross District 5, Bucharest, Romania., Jaho E; EXUS AI Labs, Athens, Greece., Vlachostergiou A; EXUS AI Labs, Athens, Greece., Suciu G; BEIA Consult International, Bucharest, Romania., Stalidi C; BEIA Consult International, Bucharest, Romania., Marcu L; BEIA Consult International, Bucharest, Romania., Annus H; MDSC Systems OÜ, Tallinn, Estonia., Kamdron K; MDSC Systems OÜ, Tallinn, Estonia., Aasamäe A; MDSC Systems OÜ, Tallinn, Estonia., Groschup M; Friedrich-Loeffler-Institut (FLI), Federal Research Institute for Animal Health, Greifswald - Insel Riems, Germany., Dietze K; Friedrich-Loeffler-Institut (FLI), Federal Research Institute for Animal Health, Greifswald - Insel Riems, Germany., Knauf S; Friedrich-Loeffler-Institut (FLI), Federal Research Institute for Animal Health, Greifswald - Insel Riems, Germany., Keller M; Friedrich-Loeffler-Institut (FLI), Federal Research Institute for Animal Health, Greifswald - Insel Riems, Germany., Mellou K; Ethnikos Organismos Dimosias Ygeias, National Public Health Organization (NPHO), Athens, Greece., Politi L; Ethnikos Organismos Dimosias Ygeias, National Public Health Organization (NPHO), Athens, Greece., Neubauer G; Austrian Institute of Technology (AIT), Vienna, Austria., Ignjatović D; Austrian Institute of Technology (AIT), Vienna, Austria., Melo AM; Bernhard-Nocht-Institute for Tropical Medicine (BNITM), Hamburg, Germany., Peham JR; Austrian Institute of Technology (AIT), Vienna, Austria., Affara M; Bernhard-Nocht-Institute for Tropical Medicine (BNITM), Hamburg, Germany., Gehre F; Bernhard-Nocht-Institute for Tropical Medicine (BNITM), Hamburg, Germany. gehre@bnitm.de. |
| Πηγή: | One health outlook [One Health Outlook] 2025 Oct 23; Vol. 7 (1), pp. 53. Date of Electronic Publication: 2025 Oct 23. |
| Τύπος έκδοσης: | Journal Article; Review |
| Γλώσσα: | English |
| Στοιχεία περιοδικού: | Publisher: BioMed Central Ltd Country of Publication: England NLM ID: 101769253 Publication Model: Electronic Cited Medium: Internet ISSN: 2524-4655 (Electronic) Linking ISSN: 25244655 NLM ISO Abbreviation: One Health Outlook Subsets: PubMed not MEDLINE |
| Imprint Name(s): | Original Publication: [London] : BioMed Central Ltd, [2019]- |
| Περίληψη: | Background: Europe and Africa are increasingly affected by (re-)emerging risk group 3 and 4, zoonotic viral disease epidemics, which not only require diagnostic BSL-3/4 laboratory capacity but also a One Health-based control strategy for efficient outbreak containment. In many European and African countries such laboratory capacity is often not readily available, and rapid response mobile laboratories (RRMLs) can play important, complementary roles in outbreak responses and pandemic preparedness activities on national, regional and international level. Main Body: The aim of the present review was to assess whether existing European and African RRML infrastructure is prepared for future One Health outbreak responses and to identify potential diagnostic gaps. Based on a literature review (2007-2021), we identified 291 mobile laboratories (Europe: 192, Africa: 99) and assessed them in respect to purpose (e.g. military, civilian), design (suitcase, modular, vehicle mounted), biosafety level, laboratory equipment, diagnostic portfolio, sample types analyzed (human, animal) and quality assurance measures. Following peaks in 2014 (Ebola/West Africa) and 2020 (COVID-19), mobile laboratory numbers have steadily increased. Whilst laboratories were originally designed to diagnose viral haemorrhagic fevers, there has been an increased focus on SARS-CoV-2 since 2020. Recently, there was a shift of African countries to develop an independent mobile laboratory capacity, rather than relying on external support for outbreak responses. Conclusion: We identified key shortcomings of existing laboratories, as the majority only process samples of human origin (not compliant with One Health principles), only 5% have sufficient capacity to diagnose emerging risk group 3/4 (arbo)viruses, 1-10% have accredited quality assurance systems in place, and mobile laboratories are not interconnected to allow concerted national and international responses. Our results reveal the gaps that should be addressed to make future responses to zoonotic, high-consequence pathogens more effective. (© 2025. The Author(s).) |
| Competing Interests: | Declarations. Ethics approval and consent to participate: Not applicable. Consent for publication: Not applicable. Competing interests: The authors declare no competing interests. |
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| Contributed Indexing: | Keywords: Africa; BSL-4; Disease outbreaks; Emerging diseases; Epidemics; Europe; Mobile laboratories; Pandemic preparedness; Risk group 3; Risk group 4 |
| Entry Date(s): | Date Created: 20251024 Date Completed: 20251024 Latest Revision: 20251027 |
| Update Code: | 20260130 |
| PubMed Central ID: | PMC12548259 |
| DOI: | 10.1186/s42522-025-00180-6 |
| PMID: | 41131594 |
| Βάση Δεδομένων: | MEDLINE |
| ISSN: | 2524-4655 |
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| DOI: | 10.1186/s42522-025-00180-6 |