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Global performance of non-invasive tests in MASLD: Insights from the G-MASLD study.

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Τίτλος: Global performance of non-invasive tests in MASLD: Insights from the G-MASLD study.
Συγγραφείς: Younossi ZM; The Global NASH/MASH Council (GNC), Washington, District of Columbia, USA.; Beatty Liver and Obesity Research Program, Inova Health System, Falls Church, Virginia, USA., de Avila L; The Global NASH/MASH Council (GNC), Washington, District of Columbia, USA.; Beatty Liver and Obesity Research Program, Inova Health System, Falls Church, Virginia, USA., Petta S; The Global NASH/MASH Council (GNC), Washington, District of Columbia, USA.; Section of Gastroenterology, PROMISE Department, University of Palermo, Palermo, Italy., Hagström H; The Global NASH/MASH Council (GNC), Washington, District of Columbia, USA.; Division of Hepatology, Department of Upper GI Diseases, Karolinska University Hospital, Stockholm, Sweden., Kim SU; The Global NASH/MASH Council (GNC), Washington, District of Columbia, USA.; Department of Internal Medicine, Yonsei University College of Medicine, Seoul, Republic of Korea., Nakajima A; The Global NASH/MASH Council (GNC), Washington, District of Columbia, USA.; Department of Gastroenterology and Hepatology, Yokohama City University Graduate School of Medicine, Yokohama, Japan., Crespo J; The Global NASH/MASH Council (GNC), Washington, District of Columbia, USA.; Gastroenterology and Hepatology Department, Clinical and Translational Research in Digestive Diseases, Valdecilla Research Institute (IDIVAL), Marques de Valdecilla University Hospital, Santander, Spain., Castera L; The Global NASH/MASH Council (GNC), Washington, District of Columbia, USA.; Department of Hepatology, Hospital Beaujon, Assistance Publique-Hôpitaux de Paris, Université Paris-Cité, Paris, France., Alkhouri N; The Global NASH/MASH Council (GNC), Washington, District of Columbia, USA.; Summit Clinical Research, San Antonio, Texas, USA., Zheng MH; The Global NASH/MASH Council (GNC), Washington, District of Columbia, USA.; MAFLD Research Center, Department of Hepatology, the First Affiliated Hospital of Wenzhou Medical University, Wenzhou, China., Treeprasertsuk S; The Global NASH/MASH Council (GNC), Washington, District of Columbia, USA.; Division of Gastroenterology, Department of Internal Medicine, Chulalongkorn University, Bangkok, Thailand., Ananchuensook P; The Global NASH/MASH Council (GNC), Washington, District of Columbia, USA.; Division of Gastroenterology, Department of Internal Medicine, Chulalongkorn University, Bangkok, Thailand., Shalimar; The Global NASH/MASH Council (GNC), Washington, District of Columbia, USA.; Department of Gastroenterology and Human Nutrition Unit, All India Institute of Medical Sciences, New Delhi, India., Tsochatzis E; The Global NASH/MASH Council (GNC), Washington, District of Columbia, USA.; University College London Institute for Liver and Digestive Health, Royal Free Hospital, London, UK., Trivikrama SK; The Global NASH/MASH Council (GNC), Washington, District of Columbia, USA.; Department of Gastroenterology, Sree Gokulam Medical College and Research Foundation, Trivandrum, Kerala, India., Balakumaran LK; The Global NASH/MASH Council (GNC), Washington, District of Columbia, USA.; Population Health and Research Institute, Medical College PO, Trivandrum, Kerala, India., Fan JG; The Global NASH/MASH Council (GNC), Washington, District of Columbia, USA.; Department of Gastroenterology, Xinhua Hospital affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China., Roberts SK; The Global NASH/MASH Council (GNC), Washington, District of Columbia, USA.; Alfred Hospital Gastroenterology Department, Monash University, Melbourne, Australia., Alswat K; The Global NASH/MASH Council (GNC), Washington, District of Columbia, USA.; Liver Disease Research Center, Department of Medicine, College of Medicine, King Saud University, Riyadh, Saudi Arabia., Wong VW; The Global NASH/MASH Council (GNC), Washington, District of Columbia, USA.; Medical Data Analytics Center, Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Hong Kong, China., Yilmaz Y; The Global NASH/MASH Council (GNC), Washington, District of Columbia, USA.; Department of Gastroenterology, School of Medicine, Recep Tayyip Erdogan University, Rize, Türkiye., Dunn W; Internal Medicine, Kansas University Medical Center, Kansas City, Kansas, USA., Francque S; The Global NASH/MASH Council (GNC), Washington, District of Columbia, USA.; Department of Gastroenterology and Hepatology, Antwerp University Hospital, Edegem, Belgium., Cordie A; The Global NASH/MASH Council (GNC), Washington, District of Columbia, USA.; Cairo University Hospitals HIV Clinic, Endemic Medicine Department, Cairo University Hospitals, Cairo, Egypt., Yu ML; The Global NASH/MASH Council (GNC), Washington, District of Columbia, USA.; Hepatobiliary Division, Department of Internal Medicine, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung, Taiwan., Ekstedt M; Department of Gastroenterology and Hepatology, Department of Health, Medicine, and Caring Sciences, Linköping University, Linköping, Sweden., Goh GB; The Global NASH/MASH Council (GNC), Washington, District of Columbia, USA.; Department of Gastroenterology and Hepatology, Singapore General Hospital, Singapore, Singapore., Oliveira CP; The Global NASH/MASH Council (GNC), Washington, District of Columbia, USA.; Department of Gastroenterology, Faculdade Medicina da Universidade de Sao Paulo, Sao Paulo, Brazil., Pessoa MG; The Global NASH/MASH Council (GNC), Washington, District of Columbia, USA.; Department of Gastroenterology, Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo - HCFMUSP, São Paulo, Brazil., Chan WK; The Global NASH/MASH Council (GNC), Washington, District of Columbia, USA.; Gastroenterology and Hepatology Unit, Department of Medicine, University of Malaya, Kuala Lumpur, Malaysia., Fernandez MIC; The Global NASH/MASH Council (GNC), Washington, District of Columbia, USA.; Department of Research and Teaching, Institute of Gastroenterology, University of Medical Sciences of Havana, Havana, Cuba., Duseja A; The Global NASH/MASH Council (GNC), Washington, District of Columbia, USA.; Department of Hepatology, Postgraduate Institute of Medical Education and Research, Chandigarh, India., Arab JP; The Global NASH/MASH Council (GNC), Washington, District of Columbia, USA.; Stravitz-Sanyal Institute for Liver Disease and Metabolic Health, Division of Gastroenterology, Hepatology, and Nutrition, Department of Internal Medicine, Virginia Commonwealth University School of Medicine, Richmond, Virginia, USA., Papatheodoridis G; The Global NASH/MASH Council (GNC), Washington, District of Columbia, USA.; First Academic Department of Gastroenterology, Medical School of National and Kapodistrian University of Athens, General Hospital of Athens 'Laiko', Athens, Greece., Sebastiani G; The Global NASH/MASH Council (GNC), Washington, District of Columbia, USA.; Division of Gastroenterology and Hepatology, Department of Medicine, McGill University Health Centre, Montreal, Canada., Villela-Nogueira C; The Global NASH/MASH Council (GNC), Washington, District of Columbia, USA.; School of Medicine, Internal Medicine Department and Hepatology Division, Clementino Fraga Filho University Hospital, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil., D'Ambrosio R; Division of Gastroenterology and Hepatology, Foundation IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milan, Italy., Lampertico P; The Global NASH/MASH Council (GNC), Washington, District of Columbia, USA.; Division of Gastroenterology and Hepatology, Foundation IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milan, Italy., Alnaamani K; The Global NASH/MASH Council (GNC), Washington, District of Columbia, USA.; Division of Gastroenterology and Hepatology, Department of Medicine, The Medical City for Military and Security Services, Muscat, Oman., Holleboom AG; The Global NASH/MASH Council (GNC), Washington, District of Columbia, USA.; Department of Vascular Medicine, Amsterdam University Medical Center, Amsterdam, The Netherlands., Valsan A; The Global NASH/MASH Council (GNC), Washington, District of Columbia, USA.; Centre for Metabolic Liver Disease and Integrated Liver Care Unit, Amrita Institute of Medical Sciences, Kochi, Kerala, India., Venu A; Centre for Metabolic Liver Disease and Integrated Liver Care Unit, Amrita Institute of Medical Sciences, Kochi, Kerala, India., El-Kassas M; The Global NASH/MASH Council (GNC), Washington, District of Columbia, USA.; Endemic Medicine Department, Faculty of Medicine, Helwan University, Cairo, Egypt., Pennisi G; Section of Gastroenterology, PROMISE Department, University of Palermo, Palermo, Italy., Shang Y; Department of Medicine, Huddinge, Karolinska Institutet, Stockholm, Sweden., Liu WY; Department of Endocrinology, the First Affiliated Hospital of Wenzhou Medical University, Wenzhou, China., Lee HW; Department of Internal Medicine, Yonsei University College of Medicine, Seoul, Republic of Korea., Kobayashi T; Department of Gastroenterology and Hepatology, Yokohama City University Graduate School of Medicine, Yokohama, Japan., Kakizaki S; The Global NASH/MASH Council (GNC), Washington, District of Columbia, USA.; Department of Clinical Research, NHO Takasaki General Medical Center, Takasaki, Japan., Caussy C; The Global NASH/MASH Council (GNC), Washington, District of Columbia, USA.; Département Endocrinologie, Diabète et Nutrition, Hôpital Lyon Sud, Hospices Civils de Lyon, Pierre-Bénite, Lyon, France., Pearlman B; The Global NASH/MASH Council (GNC), Washington, District of Columbia, USA.; Department of Graduate Medical Education, Hamilton Medical Center, Medical College of Georgia, Dalton, United States., Iruzubieta P; Gastroenterology and Hepatology Department, Clinical and Translational Research in Digestive Diseases, Valdecilla Research Institute (IDIVAL), Marques de Valdecilla University Hospital, Santander, Spain., Nadeem R; Arizona Liver Health, Chandler, Arizona, United States., Cinque F; Division of Gastroenterology and Hepatology, Department of Medicine, McGill University Health Centre, Montreal, Canada., Neonaki A; First Academic Department of Gastroenterology, Medical School of National and Kapodistrian University of Athens, General Hospital of Athens 'Laiko', Athens, Greece., Zoncapé M; Liver Unit, Department of Internal Medicine, University and Azienda Ospedaliera Universitaria Integrata of Verona, Verona, Italy., Yang RX; Department of Gastroenterology, Xinhua Hospital affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China., Song SJ; Medical Data Analytics Center, Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Hong Kong, China., Dunn N; Internal Medicine, Kansas University Medical Center, Kansas City, Kansas, USA., Gadi Z; Department of Gastroenterology and Hepatology, Antwerp University Hospital, Edegem, Belgium., Yeh ML; Center of Excellence for Metabolic Associated Fatty Liver Disease, National Sun Yat-sen University, Kaohsiung, Taiwan., Kim-Jun K; Department of Gastroenterology and Hepatology, Singapore General Hospital, Singapore, Singapore., Mahadeva S; Gastroenterology and Hepatology Unit, Department of Medicine, University of Malaya, Kuala Lumpur, Malaysia., Fabian LG; Department of Pathological Anatomy, Institute of Gastroenterology, University of Medical Sciences of Havana, Havana, Cuba., Almohsen A; Department of Medicine, Schulich School of Medicine, Western University & London Health Sciences Centre, London, Ontario, Canada., Leite N; School of Medicine, Internal Medicine Department and Hepatology Division, Clementino Fraga Filho University Hospital, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil., Pugliese N; The Global NASH/MASH Council (GNC), Washington, District of Columbia, USA.; Division of Internal Medicine and Hepatology, Department of Gastroenterology, IRCCS Humanitas Research Hospital, Rozzano, Italy., Vessby J; Department of Medical Sciences, Gastroenterology Research Group, Uppsala University, Uppsala, Sweden., Xie C; Division of Hepatology, Avera McKennan Hospital & University Health Center, Sioux Falls, United States., Choudhary NS; Hepatology, and Institute of Liver Transplantation and Regenerative Medicine, Medanta The Medicity, Gurugram, Haryana, India., Friend E; Velocity Clinical Research, Waco, Texas, United States., Poca M; Department of Gastroenterology, CIBEREHD, IR Sant Pau, Hospital de la Santa Creu i Sant Pau, Barcelona, Spain., Kawaguchi T; The Global NASH/MASH Council (GNC), Washington, District of Columbia, USA.; Division of Gastroenterology, Department of Medicine, Kurume University School of Medicine, Kurume, Japan., Russo FP; Department of Surgery, Oncology and Gastroenterology, University of Padova Gastroenterology Unit, Azienda Ospedaliera - Universita Padova, Padova, Italy., Gadano A; The Global NASH/MASH Council (GNC), Washington, District of Columbia, USA.; Liver Unit, Hospital Italiano de Buenos Aires, Buenos Aires, Argentina., Diaz LA; The Global NASH/MASH Council (GNC), Washington, District of Columbia, USA.; MASLD Research Center, Division of Gastroenterology and Hepatology, University of California San Diego, San Diego, California, United States., Singal AK; The Global NASH/MASH Council (GNC), Washington, District of Columbia, USA.; Department of Medicine, Division of Gastroenterology, Hepatology, and Nutrition, University of Louisville, Louisville, Kentucky, United States., Segrestin B; The Global NASH/MASH Council (GNC), Washington, District of Columbia, USA.; Département Endocrinologie, Diabète et Nutrition, Hôpital Lyon Sud, Hospices Civils de Lyon, Pierre-Bénite, Lyon, France., Gunn N; The Global NASH/MASH Council (GNC), Washington, District of Columbia, USA.; Velocity Clinical Research, Waco, Texas, United States., Mauricio D; The Global NASH/MASH Council (GNC), Washington, District of Columbia, USA.; Department of Endocrinology & Nutrition, CIBERDEM, IR Sant Pau, Hospital de la Santa Creu i Sant Pau, Barcelona, Spain., Arrese M; The Global NASH/MASH Council (GNC), Washington, District of Columbia, USA.; Departamento de Gastroenterología, Escuela de Medicina, Pontificia Universidad Católica de Chile, Santiago, Chile., Fracanzani A; Unit of Metabolic Disease, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milan, Italy., Lombardi R; Unit of Metabolic Disease, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milan, Italy., Lam B; The Global NASH/MASH Council (GNC), Washington, District of Columbia, USA.; Beatty Liver and Obesity Research Program, Inova Health System, Falls Church, Virginia, USA., Racila A; The Global NASH/MASH Council (GNC), Washington, District of Columbia, USA.; Beatty Liver and Obesity Research Program, Inova Health System, Falls Church, Virginia, USA., Alqahtani SA; The Global NASH/MASH Council (GNC), Washington, District of Columbia, USA.; Liver, Digestive, and Lifestyle Health Research Section, and Organ Transplant Center of Excellence, King Faisal Specialist Hospital and Research Center, Riyadh, Saudi Arabia., Stepanova M; The Global NASH/MASH Council (GNC), Washington, District of Columbia, USA.; Beatty Liver and Obesity Research Program, Inova Health System, Falls Church, Virginia, USA.; Center for Outcomes Research in Liver Disease, Washington, District of Columbia, United States.
Συλλογικό Έργο: Global NASH/MASH Council (GNC)
Πηγή: Hepatology (Baltimore, Md.) [Hepatology] 2026 Jul 01; Vol. 84 (1), pp. 161-174. Date of Electronic Publication: 2025 Oct 08.
Τύπος έκδοσης: Journal Article; Multicenter Study
Γλώσσα: English
Στοιχεία περιοδικού: Publisher: Wolters Kluwer Health, Inc Country of Publication: United States NLM ID: 8302946 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1527-3350 (Electronic) Linking ISSN: 02709139 NLM ISO Abbreviation: Hepatology Subsets: MEDLINE
Imprint Name(s): Publication: 2023- : [Philadelphia] : Wolters Kluwer Health, Inc.
Original Publication: Baltimore, MD : Williams & Wilkins, [c1981]-
Ιατρικοί όροι (MeSH): Liver Cirrhosis*/diagnosis , Liver Cirrhosis*/pathology , Liver Cirrhosis*/epidemiology , Liver Cirrhosis*/etiology , Liver*/pathology , Liver*/diagnostic imaging , Non-alcoholic Fatty Liver Disease*/diagnosis , Non-alcoholic Fatty Liver Disease*/pathology , Non-alcoholic Fatty Liver Disease*/epidemiology, Elasticity Imaging Techniques/methods ; Humans ; Female ; Male ; Middle Aged ; Adult ; Biopsy ; Severity of Illness Index ; Predictive Value of Tests
Περίληψη: Background: Metabolic dysfunction-associated steatotic liver disease (MASLD) is highly prevalent worldwide. Performance of non-invasive tests (NITs) in patients with MASLD recruited from different regions of the world was evaluated.
Methods: MASLD patients with liver biopsies and NIT data [fibrosis-4 index (FIB-4), enhanced liver fibrosis (ELF), and liver stiffness measurement (LSM)] were enrolled through the Global NASH Council collaboration (G-MASLD). FibroScan-AST (FAST) and Agile-3+/Agile-4 were calculated. NITs' performance for predicting ≥F2 (significant fibrosis), ≥F3 (advanced fibrosis), or cirrhosis (F4) was determined in patients from different regions.
Results: A total of 17,792 MASLD patients from 41 countries were included: 14% had F0, 32% F1, 18% F2, 22% F3, 13% F4 (cirrhosis); 48% NAS ≥5. Advanced fibrosis prediction by NITs was variable across regions for FIB-4 [pooled AUC (95% CI)=0.80 (0.79-0.81)], the lowest in Latin America [0.75 (0.71-0.79)], the highest in MENA [0.84 (0.82-0.87)], and ELF [pooled AUC=0.77 (0.76-0.79)], the lowest in Europe [0.72 (0.69-0.76)], the highest in North America [0.80 (0.78-0.82)]. Prediction of advanced fibrosis by LSM [pooled AUC=0.84 (0.83-0.85)] was similar across regions except North America [0.78 (0.76-0.81)]. In addition, FAST [AUC=0.75 (0.74-0.76)] and Agile-3+ [AUC=0.87 (0.86-0.88)] performed similarly across regions. Similar trends were observed for the NITs predicting significant fibrosis. Finally, the accuracy of Agile-4 for predicting cirrhosis [AUC=0.90 (0.89-0.91)] was the lowest in North America [0.85 (0.83-0.87)], the highest in MENA [0.96 (0.94-0.98)].
Conclusions: The diagnostic performance of common NITs for fibrosis in MASLD varies across the world. In the large multinational G-MASLD sample, the most accurate NITs were Agile-3+ and Agile-4 composite scores.
(Copyright © 2025 American Association for the Study of Liver Diseases.)
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Contributed Indexing: Keywords: biomarkers; chronic liver disease; diagnostic thresholds; metabolic syndrome; non-communicable diseases; outcomes; steatohepatitis; steatotic liver disease
Entry Date(s): Date Created: 20251016 Date Completed: 20260616 Latest Revision: 20260618
Update Code: 20260618
DOI: 10.1097/HEP.0000000000001564
PMID: 41100867
Βάση Δεδομένων: MEDLINE
Περιγραφή
ISSN:1527-3350
DOI:10.1097/HEP.0000000000001564