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Best practices in mouse models of skin transplantation.

Λεπτομέρειες βιβλιογραφικής εγγραφής
Τίτλος: Best practices in mouse models of skin transplantation.
Συγγραφείς: Borges TJ; Center for Transplantation Sciences, Department of Surgery, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA., Krummey SM; Department of Pathology, Johns Hopkins School of Medicine, Baltimore, Maryland, USA., Ford ML; Department of Surgery and Emory Transplant Center, Emory University, Atlanta, Georgia, USA. Electronic address: mandy.ford@emory.edu.
Πηγή: American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons [Am J Transplant] 2026 Mar; Vol. 26 (3), pp. 439-448. Date of Electronic Publication: 2025 Oct 10.
Τύπος έκδοσης: Journal Article; Review
Γλώσσα: English
Στοιχεία περιοδικού: Publisher: Elsevier Country of Publication: United States NLM ID: 100968638 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1600-6143 (Electronic) Linking ISSN: 16006135 NLM ISO Abbreviation: Am J Transplant Subsets: MEDLINE
Imprint Name(s): Publication: 2023- : [New York] : Elsevier
Original Publication: Copenhagen : Munksgaard International Publishers, 2001-
Ιατρικοί όροι (MeSH): Skin Transplantation*/methods , Graft Rejection*/immunology , Graft Rejection*/etiology , Graft Rejection*/prevention & control , Disease Models, Animal*, Graft Survival/immunology ; Animals ; Mice ; Models, Animal ; Humans
Περίληψη: The murine skin transplant model has been used for decades as a sensitive in vivo model in which to dissect mechanistic aspects of alloreactivity. Indeed, seminal work defining the nature of alloreactivity was accomplished in the murine skin graft model. In the modern era, the incorporation of genetically altered animals, pharmacologic manipulation, and multiomics approaches in the murine skin graft model has significantly increased the mechanistic insight that can be gleaned from these studies. Because skin grafts are not primarily vascularized, the immune response against them is dominated by a CD8+ T cell response, with a lesser but important contribution of alloreactive CD4+ T cells. In contrast, donor-reactive antibody plays a lesser role in mediating skin transplant rejection. Importantly, the results of pharmacologic inhibition of T cell-directed novel targets for immunosuppression in transplantation in the murine skin graft model have largely reflected the results subsequently obtained in nonhuman primate renal transplant studies, demonstrating the physiologic relevance of the model. In this minireview, we further discuss the relative benefits and limitations of murine skin transplantation as a model of alloreactivity.
(Copyright © 2025 American Society of Transplantation & American Society of Transplant Surgeons. Published by Elsevier Inc. All rights reserved.)
Competing Interests: Declaration of competing interest The authors of this manuscript have conflicts of interest to disclose as described by American Journal of Transplantation. Mandy L. Ford reports a relationship with Eledon that includes: consulting or advisory. Mandy L. Ford reports a relationship with Sanofi that includes: consulting or advisory. Mandy L. Ford reports a relationship with Veloxis Pharmaceuticals Inc that includes: consulting or advisory. The other authors of this manuscript have no conflicts of interest to disclose as described by American Journal of Transplantation.
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Grant Information: R01 AI152516 United States AI NIAID NIH HHS; R01 AI164716 United States AI NIAID NIH HHS
Contributed Indexing: Keywords: CD4(+) T lymphocyte; CD8(+) T lymphocyte; T cell-mediated rejection; mouse model; skin transplantation
Entry Date(s): Date Created: 20251012 Date Completed: 20260307 Latest Revision: 20260919
Update Code: 20260919
PubMed Central ID: PMC12697377
DOI: 10.1016/j.ajt.2025.09.025
PMID: 41077307
Βάση Δεδομένων: MEDLINE
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  Data: Best practices in mouse models of skin transplantation.
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  Data: <searchLink fieldCode="AU" term="%22Borges+TJ%22">Borges TJ</searchLink>; Center for Transplantation Sciences, Department of Surgery, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA.<br /><searchLink fieldCode="AU" term="%22Krummey+SM%22">Krummey SM</searchLink>; Department of Pathology, Johns Hopkins School of Medicine, Baltimore, Maryland, USA.<br /><searchLink fieldCode="AU" term="%22Ford+ML%22">Ford ML</searchLink>; Department of Surgery and Emory Transplant Center, Emory University, Atlanta, Georgia, USA. Electronic address: mandy.ford@emory.edu.
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  Data: <searchLink fieldCode="JN" term="%22100968638%22">American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons</searchLink> [Am J Transplant] 2026 Mar; Vol. 26 (3), pp. 439-448. <i>Date of Electronic Publication: </i>2025 Oct 10.
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  Data: <i>Publication</i>: 2023- : [New York] : Elsevier<br /><i>Original Publication</i>: Copenhagen : Munksgaard International Publishers, 2001-
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  Data: <searchLink fieldCode="MM" term="%22Skin+Transplantation%22">Skin Transplantation*</searchLink>/<searchLink fieldCode="MM" term="%22Skin+Transplantation+methods%22">methods</searchLink> <br /><searchLink fieldCode="MM" term="%22Graft+Rejection%22">Graft Rejection*</searchLink>/<searchLink fieldCode="MM" term="%22Graft+Rejection+immunology%22">immunology</searchLink> <br /><searchLink fieldCode="MM" term="%22Graft+Rejection%22">Graft Rejection*</searchLink>/<searchLink fieldCode="MM" term="%22Graft+Rejection+etiology%22">etiology</searchLink> <br /><searchLink fieldCode="MM" term="%22Graft+Rejection%22">Graft Rejection*</searchLink>/<searchLink fieldCode="MM" term="%22Graft+Rejection+prevention+%26+control%22">prevention & control</searchLink> <br /><searchLink fieldCode="MM" term="%22Disease+Models%2C+Animal%22">Disease Models, Animal*</searchLink><br /><searchLink fieldCode="MH" term="%22Graft+Survival%22">Graft Survival</searchLink>/<searchLink fieldCode="MH" term="%22Graft+Survival+immunology%22">immunology</searchLink> ; <searchLink fieldCode="MH" term="%22Animals%22">Animals</searchLink> ; <searchLink fieldCode="MH" term="%22Mice%22">Mice</searchLink> ; <searchLink fieldCode="MH" term="%22Models%2C+Animal%22">Models, Animal</searchLink> ; <searchLink fieldCode="MH" term="%22Humans%22">Humans</searchLink>
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  Data: The murine skin transplant model has been used for decades as a sensitive in vivo model in which to dissect mechanistic aspects of alloreactivity. Indeed, seminal work defining the nature of alloreactivity was accomplished in the murine skin graft model. In the modern era, the incorporation of genetically altered animals, pharmacologic manipulation, and multiomics approaches in the murine skin graft model has significantly increased the mechanistic insight that can be gleaned from these studies. Because skin grafts are not primarily vascularized, the immune response against them is dominated by a CD8<superscript>+</superscript> T cell response, with a lesser but important contribution of alloreactive CD4<superscript>+</superscript> T cells. In contrast, donor-reactive antibody plays a lesser role in mediating skin transplant rejection. Importantly, the results of pharmacologic inhibition of T cell-directed novel targets for immunosuppression in transplantation in the murine skin graft model have largely reflected the results subsequently obtained in nonhuman primate renal transplant studies, demonstrating the physiologic relevance of the model. In this minireview, we further discuss the relative benefits and limitations of murine skin transplantation as a model of alloreactivity.<br /> (Copyright © 2025 American Society of Transplantation & American Society of Transplant Surgeons. Published by Elsevier Inc. All rights reserved.)
– Name: Abstract
  Label: Competing Interests
  Group: Ab
  Data: Declaration of competing interest The authors of this manuscript have conflicts of interest to disclose as described by American Journal of Transplantation. Mandy L. Ford reports a relationship with Eledon that includes: consulting or advisory. Mandy L. Ford reports a relationship with Sanofi that includes: consulting or advisory. Mandy L. Ford reports a relationship with Veloxis Pharmaceuticals Inc that includes: consulting or advisory. The other authors of this manuscript have no conflicts of interest to disclose as described by American Journal of Transplantation.
– Name: Ref
  Label: References
  Group: RefInfo
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  Data: <i>Keywords: </i>CD4(+) T lymphocyte; CD8(+) T lymphocyte; T cell-mediated rejection; mouse model; skin transplantation
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        Value: 10.1016/j.ajt.2025.09.025
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        Text: English
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        StartPage: 439
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      – SubjectFull: Graft Survival immunology
        Type: general
      – SubjectFull: Animals
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      – SubjectFull: Mice
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      – SubjectFull: Humans
        Type: general
      – SubjectFull: Skin Transplantation methods
        Type: general
      – SubjectFull: Graft Rejection immunology
        Type: general
      – SubjectFull: Graft Rejection etiology
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      – SubjectFull: Graft Rejection prevention & control
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      – SubjectFull: Disease Models, Animal
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      – TitleFull: Best practices in mouse models of skin transplantation.
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              Text: 2026 Mar
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          Titles:
            – TitleFull: American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons
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