Academic Journal
Seroconversion of SSA and the Development of Inflammatory Myositis in a Patient With Chronic Joint Pain: A Potential Overlap Connective Tissue Disease.
| Τίτλος: | Seroconversion of SSA and the Development of Inflammatory Myositis in a Patient With Chronic Joint Pain: A Potential Overlap Connective Tissue Disease. |
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| Συγγραφείς: | Maraj D; Internal Medicine, Henry Ford Health System, Jackson, USA., El-Feki I; Internal Medicine, Henry Ford Health System, Jackson, USA., Zebda H; Rheumatology, Henry Ford Health System, Detroit, USA. |
| Πηγή: | Cureus [Cureus] 2025 Sep 04; Vol. 17 (9), pp. e91619. Date of Electronic Publication: 2025 Sep 04 (Print Publication: 2025). |
| Τύπος έκδοσης: | Case Reports; Journal Article |
| Γλώσσα: | English |
| Στοιχεία περιοδικού: | Publisher: Cureus, Inc Country of Publication: United States NLM ID: 101596737 Publication Model: eCollection Cited Medium: Print ISSN: 2168-8184 (Print) Linking ISSN: 21688184 NLM ISO Abbreviation: Cureus Subsets: PubMed not MEDLINE |
| Imprint Name(s): | Original Publication: Palo Alto, CA : Cureus, Inc. |
| Περίληψη: | We present the case of a 48-year-old female with a complex medical history, including chronic joint pain on methadone and chronic obstructive pulmonary disease (COPD), who developed right forearm myositis following a series of orthopedic procedures and infections. Initially thought to be infectious in origin, subsequent investigations revealed chronic inflammation without infection. The patient's serologic profile evolved over time, with new-onset SSA antibody positivity, positive antinuclear antibody (ANA) and rheumatoid factor (RF), and concern for overlapping connective tissue disease. This case highlights the diagnostic complexity and evolving nature of autoimmune conditions, particularly in patients with non-specific musculoskeletal symptoms and comorbidities. (Copyright © 2025, Maraj et al.) |
| Competing Interests: | Human subjects: Informed consent for treatment and open access publication was obtained or waived by all participants in this study. Conflicts of interest: In compliance with the ICMJE uniform disclosure form, all authors declare the following: Payment/services info: All authors have declared that no financial support was received from any organization for the submitted work. Financial relationships: All authors have declared that they have no financial relationships at present or within the previous three years with any organizations that might have an interest in the submitted work. Other relationships: All authors have declared that there are no other relationships or activities that could appear to have influenced the submitted work. |
| References: | Clin Exp Rheumatol. 2019 Sep-Oct;37(5):858-861. (PMID: 31074729) J Clin Pathol. 2001 May;54(5):340-7. (PMID: 11328831) Curr Rheumatol Rep. 2011 Jun;13(3):182-91. (PMID: 21365210) Ann Rheum Dis. 2005 Mar;64(3):347-54. (PMID: 15498797) BMJ. 2012 Jun 14;344:e3821. (PMID: 22700787) Ann Rheum Dis. 2017 Dec;76(12):1955-1964. (PMID: 29079590) Arthritis Rheum. 2012 Dec;64(12):4040-7. (PMID: 22932861) Front Med (Lausanne). 2023 Jun 23;10:1183535. (PMID: 37425332) Semin Nephrol. 2011 Jul;31(4):376-89. (PMID: 21839371) Autoimmun Rev. 2013 Jan;12(3):363-73. (PMID: 22743033) |
| Contributed Indexing: | Keywords: anti-ssa; connective tissue disease; inflammatory myositis; mixed connective tissue disease; myositis |
| Entry Date(s): | Date Created: 20251008 Date Completed: 20251008 Latest Revision: 20251010 |
| Update Code: | 20260130 |
| PubMed Central ID: | PMC12498201 |
| DOI: | 10.7759/cureus.91619 |
| PMID: | 41058845 |
| Βάση Δεδομένων: | MEDLINE |
| ISSN: | 2168-8184 |
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| DOI: | 10.7759/cureus.91619 |