Immobilized pigeon pea urease on chitosan-PEG biocomposite for concurrent urea sensing in milk and blood samples.

Λεπτομέρειες βιβλιογραφικής εγγραφής
Τίτλος: Immobilized pigeon pea urease on chitosan-PEG biocomposite for concurrent urea sensing in milk and blood samples.
Συγγραφείς: Kumar P; School of Biotechnology, Institute of Science, Banaras Hindu University, Varanasi 221005, India., Ghosal A; School of Biotechnology, Institute of Science, Banaras Hindu University, Varanasi 221005, India., Kayastha AM; School of Biotechnology, Institute of Science, Banaras Hindu University, Varanasi 221005, India. Electronic address: kayasthabhu@gmail.com.
Πηγή: Food chemistry [Food Chem] 2025 Dec 15; Vol. 495 (Pt 3), pp. 146509. Date of Electronic Publication: 2025 Sep 25.
Τύπος έκδοσης: Journal Article; Evaluation Study
Γλώσσα: English
Στοιχεία περιοδικού: Publisher: Elsevier Applied Science Publishers Country of Publication: England NLM ID: 7702639 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-7072 (Electronic) Linking ISSN: 03088146 NLM ISO Abbreviation: Food Chem Subsets: MEDLINE
Imprint Name(s): Publication: Barking : Elsevier Applied Science Publishers
Original Publication: Barking, Eng., Applied Science Publishers.
Ιατρικοί όροι (MeSH): Urease*/chemistry , Milk*/chemistry , Urea*/blood , Urea*/analysis , Cajanus*/enzymology , Cajanus*/chemistry , Plant Proteins*/chemistry , Biosensing Techniques*/methods , Biosensing Techniques*/instrumentation, Chitosan/chemistry ; Enzymes, Immobilized/chemistry ; Polyethylene Glycols/chemistry ; Animals ; Cattle ; Kinetics
Περίληψη: The ubiquitous hydrolytic enzyme urease converts urea into ammonia and carbon dioxide, making it an essential indicator for dairy product quality and kidney health. We developed a biocomposite sensor to meet this diagnostic necessity. This innovation strategically incorporates pigeon pea seed urease into chitosan-PEG. We verified our predicted model with a 91.30 % immobilization efficiency via our thorough process. The immobilized urease showed strong catalytic activity, with a Vmax of 3194 μmol/min/mg and a Km of 0.373 mM. Optimal activity was observed at 90 °C and pH 8.0. Additionally, it exhibited exceptional operational stability, maintaining 56 % activity over 200 days at 4 °C and 60 % reusability over 11 cycles. The sensor showed a wide linear detection range (5-400 mg/dL) with high sensitivity (LOD 3.10 (±0.155) mg/dL, LOQ 10.36 (±0.510) mg/dL). Its high selectivity (Ksel < 0.08) ensures precise urea detection in complex milk and blood matrices. This stable and reproducible biocomposite is a breakthrough in dairy and healthcare analytical tools.
(Copyright © 2025 Elsevier Ltd. All rights reserved.)
Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
Contributed Indexing: Keywords: Biocomposite; Chitosan; Milk urea; Pigeon pea; Polyethylene glycol; Urease
Substance Nomenclature: EC 3.5.1.5 (Urease)
9012-76-4 (Chitosan)
8W8T17847W (Urea)
0 (Enzymes, Immobilized)
3WJQ0SDW1A (Polyethylene Glycols)
0 (Plant Proteins)
Entry Date(s): Date Created: 20251001 Date Completed: 20251118 Latest Revision: 20251118
Update Code: 20260130
DOI: 10.1016/j.foodchem.2025.146509
PMID: 41033027
Βάση Δεδομένων: MEDLINE
Περιγραφή
ISSN:1873-7072
DOI:10.1016/j.foodchem.2025.146509