Endocannabinoids Mediate Racial/Ethnic Discrimination Prediction of Posttraumatic Stress Disorder Symptoms Moderated by Resting-State Functional Connectivity in Black and African American Individuals.

Λεπτομέρειες βιβλιογραφικής εγγραφής
Τίτλος:	Endocannabinoids Mediate Racial/Ethnic Discrimination Prediction of Posttraumatic Stress Disorder Symptoms Moderated by Resting-State Functional Connectivity in Black and African American Individuals.
Συγγραφείς:	Albertina EA; Department of Psychology, University of Wisconsin-Milwaukee, Milwaukee, Wisconsin. Electronic address: alberti8@uwm.edu., Torres L; Department of Psychology, Marquette University, Milwaukee, Wisconsin., Sauber G; Department of Pharmacology and Toxicology and Neuroscience Research Center, Medical College of Wisconsin, Milwaukee, Wisconsin., Hillard CJ; Department of Pharmacology and Toxicology and Neuroscience Research Center, Medical College of Wisconsin, Milwaukee, Wisconsin., Fitzgerald JM; Department of Psychology, Marquette University, Milwaukee, Wisconsin., deRoon-Cassini TA; Department of Surgery and Comprehensive Injury Center, Medical College of Wisconsin, Milwaukee, Wisconsin; Division of Data Surveillance and Informatics, Comprehensive Injury Center, Milwaukee, Wisconsin., Larson CL; Department of Psychology, University of Wisconsin-Milwaukee, Milwaukee, Wisconsin.
Πηγή:	Biological psychiatry. Cognitive neuroscience and neuroimaging [Biol Psychiatry Cogn Neurosci Neuroimaging] 2026 Oct; Vol. 11 (10), pp. 1308-1318. Date of Electronic Publication: 2025 Sep 26.
Τύπος έκδοσης:	Journal Article
Γλώσσα:	English
Στοιχεία περιοδικού:	Publisher: Elsevier, Inc Country of Publication: United States NLM ID: 101671285 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2451-9030 (Electronic) Linking ISSN: 24519022 NLM ISO Abbreviation: Biol Psychiatry Cogn Neurosci Neuroimaging Subsets: MEDLINE
Imprint Name(s):	Original Publication: New York, NY : Elsevier, Inc., [2016]-
Ιατρικοί όροι (MeSH):	Stress Disorders, Post-Traumatic/physiopathology , Stress Disorders, Post-Traumatic/ethnology , Stress Disorders, Post-Traumatic/metabolism , Stress Disorders, Post-Traumatic/diagnostic imaging , Black or African American/ethnology , Endocannabinoids/blood , Endocannabinoids/metabolism , Default Mode Network/physiopathology , Default Mode Network/diagnostic imaging , Racism , Connectome*, Humans ; Male ; Female ; Adult ; Magnetic Resonance Imaging
Περίληψη:	Background: Individuals from marginalized ethnoracial groups face higher risk for posttraumatic stress disorder (PTSD) symptoms, exacerbated by experiencing racial/ethnic discrimination. Previous work separately explored the endocannabinoid (eCB) system and functional connectivity response to stress/trauma and suggested that experiences of chronic minority stress, such as racial discrimination, contribute to eCB tone and resting-state functional connectivity. We explored how circulating eCB tone, in conjunction with resting-state connectivity, contributes to increased risk for PTSD symptoms following trauma among individuals experiencing discrimination. Methods: Black/African Americans (n = 74; mean age = 33.81 years) were recruited from a level 1 trauma center. Correlational and linear models explored whether experiences of racial/ethnic discrimination (Perceived Ethnic Racial Discrimination Questionnaire), eCB (AEA [N-arachidonoylethanolamine], 2-AG [2-arachidonoylglycerol]) concentrations, default mode network (DMN) functional connectivity, or salience network (SN) functional connectivity were associated with PTSD symptoms (PTSD Checklist for DSM-5). Then, we explored moderated mediation models in which discrimination predicted PTSD symptoms with eCB concentration as a mediator and functional connectivity as a moderator. Results: Discrimination was correlated with PTSD symptoms (r = 0.50), serum AEA concentration (r = 0.43), and DMN connectivity (r = 0.23). When including urine Δ⁹-tetrahydrocannabinol, lifetime trauma, age, and sex as covariates, AEA concentration was associated with PTSD symptoms (r = 0.30) and DMN connectivity (r = 0.24). AEA mediated the relationship between discrimination and PTSD symptoms, and SN connectivity moderated this mediation (B = 52.46). Conclusions: Our findings highlight how racial/ethnic discrimination impacts neurobiological systems that may lead to increased vulnerability for PTSD symptoms following an injury. Future work should continue to explore biological factors associated with the socioecological model of health as mechanisms of risk for adverse outcomes following trauma. (Copyright © 2025 Society of Biological Psychiatry. Published by Elsevier Inc. All rights reserved.)
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Grant Information:	R56 MH116656 United States MH NIMH NIH HHS
Contributed Indexing:	Keywords: Black/African American; Endocannabinoid; Moderated mediation; PTSD; Racial/ethnic discrimination; Resting-state functional connectivity
Substance Nomenclature:	0 (Endocannabinoids)
Entry Date(s):	Date Created: 20250928 Date Completed: 20261005 Latest Revision: 20261007
Update Code:	20261007
PubMed Central ID:	PMC12857617
DOI:	10.1016/j.bpsc.2025.09.016
PMID:	41016700
Βάση Δεδομένων:	MEDLINE

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Περιγραφή
ISSN:	2451-9030
DOI:	10.1016/j.bpsc.2025.09.016