Academic Journal
Inorganic Ion Permeation through Human Dentinal Tubules: Implications for Bioactive Endodontic and Desensitizing Therapies.
| Τίτλος: | Inorganic Ion Permeation through Human Dentinal Tubules: Implications for Bioactive Endodontic and Desensitizing Therapies. |
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| Συγγραφείς: | Feng TW; Graduate Institute of Oral Biology, School of Dentistry, National Taiwan University, Taipei, Taiwan., Hsieh MF; Department of Biomedical Engineering, Chung Yuan Christian University, Taoyuan, Taiwan., Liu ST; Department of Chemistry, National Taiwan University, Taipei, Taiwan., Lin CP; Graduate Institute of Clinical Dentistry, School of Dentistry, National Taiwan University, Taipei, Taiwan; Department of Dentistry, National Taiwan University Hospital, College of Medicine, National Taiwan University, Taipei, Taiwan; School of Dentistry, College of Dental Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan. Electronic address: chunpinlin@gmail.com. |
| Πηγή: | Journal of endodontics [J Endod] 2026 Jan; Vol. 52 (1), pp. 125-133.e2. Date of Electronic Publication: 2025 Sep 26. |
| Τύπος έκδοσης: | Journal Article |
| Γλώσσα: | English |
| Στοιχεία περιοδικού: | Publisher: Elsevier Country of Publication: United States NLM ID: 7511484 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1878-3554 (Electronic) Linking ISSN: 00992399 NLM ISO Abbreviation: J Endod Subsets: MEDLINE |
| Imprint Name(s): | Publication: New York : Elsevier Original Publication: Chicago, American Dental Assocation, <1975-1982>. |
| Ιατρικοί όροι (MeSH): | Dentin*/metabolism , Dentin*/ultrastructure , Dentin Permeability*, Humans ; Hydrogen-Ion Concentration ; Microscopy, Electron, Scanning ; Ions ; Molecular Weight ; Dentin Desensitizing Agents |
| Περίληψη: | Introduction: This study aimed to evaluate the effects of pH, molecular weight, and ion charge on the permeation efficiency of selected inorganic ions through dentinal tubules. Methods: Standardized 0.5 mm-thick human dentin slices were prepared and exposed to various inorganic salt solutions under pH = 4, 7, and 10 conditions. Ion permeation was quantified over a 60-minute period. Morphologic changes were examined via scanning electron microscopy. ANOVA and Spearman's correlation were used to analyze the influence of multiple variables on the diffusion of ions. Results: pH values were found to be the most influential factor: ion permeation is significantly enhanced under acidic environments and is hindered under alkaline conditions. Molecular weight and ion charge also affected diffusion, with lower molecular weight and +1 charge ions showing superior permeation. No significant difference was observed between cations and anions. Scanning electron microscopy analysis revealed no crystal deposition or tubule occlusion under the conditions investigated in this work. Conclusions: Ion permeation through dentinal tubules is primarily governed by environmental pH, followed by ion charge and molecular weight. These findings inform the rational design of ion-releasing dental materials tailored for acidic environments. Further research should explore long-term effects and multiion interactions to enhance clinical relevance. (Copyright © 2025 The Authors. Published by Elsevier Inc. All rights reserved.) |
| Contributed Indexing: | Keywords: Dentinal tubules; inorganic salts; ion permeation; pH-dependent diffusion |
| Substance Nomenclature: | 0 (Ions) 0 (Dentin Desensitizing Agents) |
| Entry Date(s): | Date Created: 20250928 Date Completed: 20251218 Latest Revision: 20251218 |
| Update Code: | 20260130 |
| DOI: | 10.1016/j.joen.2025.09.011 |
| PMID: | 41016427 |
| Βάση Δεδομένων: | MEDLINE |
| ISSN: | 1878-3554 |
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| DOI: | 10.1016/j.joen.2025.09.011 |