Wound Dressing Cryogel Materials Based on Poly(vinyl alcohol), Hyaluronic Acid, and Ag2O Nanoparticles.

Λεπτομέρειες βιβλιογραφικής εγγραφής
Τίτλος:	Wound Dressing Cryogel Materials Based on Poly(vinyl alcohol), Hyaluronic Acid, and Ag2O Nanoparticles.
Συγγραφείς:	Demchenko V; E.O. Paton Electric Welding Institute, The National Academy of Sciences of Ukraine, Kyiv 03150, Ukraine.; International Polish-Ukrainian Research Laboratory ADPOLCOM, Zabrze 41819, Poland., Mamunya Y; E.O. Paton Electric Welding Institute, The National Academy of Sciences of Ukraine, Kyiv 03150, Ukraine.; International Polish-Ukrainian Research Laboratory ADPOLCOM, Zabrze 41819, Poland., Sytnyk I; E.O. Paton Electric Welding Institute, The National Academy of Sciences of Ukraine, Kyiv 03150, Ukraine., Iurzhenko M; E.O. Paton Electric Welding Institute, The National Academy of Sciences of Ukraine, Kyiv 03150, Ukraine.; International Polish-Ukrainian Research Laboratory ADPOLCOM, Zabrze 41819, Poland., Rybalchenko N; Zabolotny Institute of Microbiology and Virology, The National Academy of Sciences of Ukraine, Kyiv 03143, Ukraine., Zahorodnia S; Zabolotny Institute of Microbiology and Virology, The National Academy of Sciences of Ukraine, Kyiv 03143, Ukraine., Demchenko O; National Research Center for Radiation Medicine, Hematology and Oncology, The National Academy of Medical Sciences of Ukraine, Kyiv 04050, Ukraine., Rushkovsky S; Taras Shevchenko National University of Kyiv, Kyiv 04050, Ukraine., Kunytskyi D; E.O. Paton Electric Welding Institute, The National Academy of Sciences of Ukraine, Kyiv 03150, Ukraine., Zeng D; E.O. Paton Electric Welding Institute, The National Academy of Sciences of Ukraine, Kyiv 03150, Ukraine., Talaniuk V; Centre of Polymer and Carbon Materials, The Polish Academy of Sciences, Zabrze 41-8191, Poland., Musioł M; Centre of Polymer and Carbon Materials, The Polish Academy of Sciences, Zabrze 41-8191, Poland.
Πηγή:	ACS applied materials & interfaces [ACS Appl Mater Interfaces] 2025 Sep 24; Vol. 17 (38), pp. 53312-53326. Date of Electronic Publication: 2025 Sep 12.
Τύπος έκδοσης:	Journal Article
Γλώσσα:	English
Στοιχεία περιοδικού:	Publisher: American Chemical Society Country of Publication: United States NLM ID: 101504991 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1944-8252 (Electronic) Linking ISSN: 19448244 NLM ISO Abbreviation: ACS Appl Mater Interfaces Subsets: MEDLINE
Imprint Name(s):	Original Publication: Washington, D.C. : American Chemical Society
Ιατρικοί όροι (MeSH):	Polyvinyl Alcohol/chemistry , Hyaluronic Acid/chemistry , Hyaluronic Acid/pharmacology , Cryogels/chemistry , Cryogels/pharmacology , Silver Compounds/chemistry , Silver Compounds/pharmacology , Metal Nanoparticles/chemistry , Anti-Bacterial Agents/chemistry , Anti-Bacterial Agents/pharmacology , Bandages*, Silver/chemistry ; Escherichia coli/drug effects ; Staphylococcus aureus/drug effects ; Wound Healing/drug effects ; Animals ; Cell Line ; Oxides
Περίληψη:	Hydrogel materials based on poly(vinyl alcohol) (PVA) and silver nanoparticles are used as wound dressings. However, chemical reducing agents, ultraviolet irradiation, and radiation irradiation are mainly used to reduce silver ions to nanoparticles in hydrogel dressings. In this study, polymeric cryogel materials based on poly(vinyl alcohol), hyaluronic acid (HA), and Ag2O nanoparticles were synthesized by reducing silver ions with hyaluronic acid followed by freezing and thawing of the samples. Structural features, thermophysical, mechanical, antimicrobial, cytotoxic and genotoxic properties of PVA-Ag-HA polymeric cryogel materials were studied by wide-angle X-ray scattering (WAXS), differential scanning calorimetry (DSC), thermogravimetric analysis (TGA), mechanical tests, antimicrobial, cytotoxic and genotoxic studies. Studies of cryogel materials using wide-angle X-ray scattering showed that the PVA-HA composite has a higher degree of crystallinity compared to the pure PVA. It was found that during the formation of samples, silver ions are reduced in the polymer systems PVA-HA-Ag⁺ at T = 85 °C, within 1 h with the formation of Ag2O nanoparticles. The addition of hyaluronic acid to the composition of PVA cryogel increases the water absorption of the samples, and a decrease in the freezing time and concentration of nanoparticles leads to an increase in the water absorption of PVA-HA cryogel materials. The thermal stability of all the studied samples, except HA, practically does not change up to a temperature of 200 °C. For the studied cryogel materials, the tensile strength increases with increasing freezing time and concentration of Ag2O nanoparticles up to 0.5 wt %. PVA-HA-Ag2O cryogel nanocomposites exhibited antimicrobial activity against Staphylococcus aureus, Staphylococcus epidermidis, and Escherichia coli at silver oxide nanoparticle concentrations of ≥0.05 wt %. The obtained nanocomposites with low concentrations of Ag2O nanoparticles were not toxic. They did not inhibit the viability of MDCK and L-929 cell cultures at silver oxide nanoparticle concentrations of ≥0.1 wt %. When studying the genotoxic properties of cryogel materials, no mutagenic and clastogenic activity was detected. The obtained materials have potential applications for the creation of dressings for the treatment of wounds of various infectious nature.
Contributed Indexing:	Keywords: Ag2O-containing cryogel materials; antimicrobial activity; cytotoxicity; genotoxicity; hyaluronic acid; morphology; poly(vinyl alcohol); properties; structure
Substance Nomenclature:	9002-89-5 (Polyvinyl Alcohol) 9004-61-9 (Hyaluronic Acid) 0 (Cryogels) 897WUN6G6T (disilver oxide) 0 (Silver Compounds) 3M4G523W1G (Silver) 0 (Anti-Bacterial Agents) 0 (Oxides)
Entry Date(s):	Date Created: 20250912 Date Completed: 20250925 Latest Revision: 20260127
Update Code:	20260130
DOI:	10.1021/acsami.5c14960
PMID:	40938142
Βάση Δεδομένων:	MEDLINE

Περιγραφή
ISSN:	1944-8252
DOI:	10.1021/acsami.5c14960