Academic Journal
Selectin E upregulation upon forkhead box P1 loss augments neutrophil infiltration and brain damage in hypertensive intracerebral hemorrhage.
| Τίτλος: | Selectin E upregulation upon forkhead box P1 loss augments neutrophil infiltration and brain damage in hypertensive intracerebral hemorrhage. |
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| Συγγραφείς: | Wang N; Department 2 of Neurosurgery, Affiliated Hospital of Hebei University of Engineering, Handan 056000 Hebei, PR China., Wu J; Department 2 of Neurosurgery, Affiliated Hospital of Hebei University of Engineering, Handan 056000 Hebei, PR China., Song Z; Department 2 of Neurosurgery, Affiliated Hospital of Hebei University of Engineering, Handan 056000 Hebei, PR China., Wang H; Department 2 of Neurosurgery, Affiliated Hospital of Hebei University of Engineering, Handan 056000 Hebei, PR China., Zhao Y; Department 1 of Respiratory and Critical Care Medicine, Affiliated Hospital of Hebei University of Engineering, Handan 056000 Hebei, PR China. Electronic address: zhaoyan9261@163.com. |
| Πηγή: | Brain research [Brain Res] 2025 Nov 01; Vol. 1866, pp. 149901. Date of Electronic Publication: 2025 Aug 26. |
| Τύπος έκδοσης: | Journal Article |
| Γλώσσα: | English |
| Στοιχεία περιοδικού: | Publisher: Elsevier/North-Holland Biomedical Press Country of Publication: Netherlands NLM ID: 0045503 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1872-6240 (Electronic) Linking ISSN: 00068993 NLM ISO Abbreviation: Brain Res Subsets: MEDLINE |
| Imprint Name(s): | Original Publication: Amsterdam Elsevier/North-Holland Biomedical Press. |
| Ιατρικοί όροι (MeSH): | Forkhead Transcription Factors*/metabolism , Forkhead Transcription Factors*/genetics , Neutrophil Infiltration*/physiology , Intracranial Hemorrhage, Hypertensive*/metabolism , Intracranial Hemorrhage, Hypertensive*/pathology , E-Selectin*/metabolism , E-Selectin*/genetics , Repressor Proteins*/metabolism , Repressor Proteins*/genetics , Brain Injuries*/metabolism, Blood-Brain Barrier/metabolism ; Endothelial Cells/metabolism ; Brain/metabolism ; Brain/pathology ; Neutrophils/metabolism ; Animals ; Mice ; Male ; Up-Regulation ; Humans ; Mice, Inbred C57BL ; Disease Models, Animal |
| Περίληψη: | Hypertension in the brain may lead to hypertensive intracerebral hemorrhage (HICH), a devastating disease. This study, grounded on bioinformatics insights, aims to investigate the functions of Selectin E (SELE) and forkhead box P1 (FOXP1) in the progression of HICH. Increased SELE expression was detected in the striatum of a mouse model of HICH generated via angiotensin II and L-NAME treatments. Knockdown of SELE alleviated hemorrhage, neutrophil infiltration, and blood-brain barrier (BBB) rupture in the mouse brain. FOXP1, poorly expressed in the HICH mice, was found to repress SELE transcription by binding to its promoter region. Overexpression of FOXP1 resulted in analogous alleviating effects in the HICH mice; however, the effects were abrogated by the additional SELE overexpression. In vitro, human brain microvascular endothelial cells (HBMECs) were treated with thrombin to generate a cellular model of ICH, followed by co-culture with HL-60 cell-derived neutrophils. The FOXP1 overexpression reduced the adhesion of neutrophils, and it alleviated HBMEC apoptosis and permeability while enhancing angiogenesis. Still, these effects were counteracted by the SELE upregulation. In conclusion, this study demonstrates that SELE upregulation upon FOXP1 loss is associated with neutrophil infiltration and BBB rupture in HICH. (Copyright © 2025 Elsevier B.V. All rights reserved.) |
| Competing Interests: | Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. |
| Contributed Indexing: | Keywords: Blood-brain barrier rupture; Forkhead box P1; Hypertensive intracerebral hemorrhage; Neutrophil infiltration; Selectin E |
| Substance Nomenclature: | 0 (Forkhead Transcription Factors) 0 (E-Selectin) 0 (Foxp1 protein, mouse) 0 (Repressor Proteins) |
| Entry Date(s): | Date Created: 20250828 Date Completed: 20250927 Latest Revision: 20250927 |
| Update Code: | 20260130 |
| DOI: | 10.1016/j.brainres.2025.149901 |
| PMID: | 40876566 |
| Βάση Δεδομένων: | MEDLINE |
| ISSN: | 1872-6240 |
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| DOI: | 10.1016/j.brainres.2025.149901 |