Academic Journal
Experimental analysis of blast shock wave-induced injuries in rats: Neurobehavioral and tissue damage assessments.
| Τίτλος: | Experimental analysis of blast shock wave-induced injuries in rats: Neurobehavioral and tissue damage assessments. |
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| Συγγραφείς: | Yu B; Institute for Hygiene of Ordnance Industry, Xi'an 710065, China., Wang H; Institute for Hygiene of Ordnance Industry, Xi'an 710065, China., Fan X; Institute for Hygiene of Ordnance Industry, Xi'an 710065, China., Li L; Institute for Hygiene of Ordnance Industry, Xi'an 710065, China., Li X; Institute for Hygiene of Ordnance Industry, Xi'an 710065, China., Zhang Y; Institute for Hygiene of Ordnance Industry, Xi'an 710065, China., Ma J; Institute for Hygiene of Ordnance Industry, Xi'an 710065, China., Ma N; Institute for Hygiene of Ordnance Industry, Xi'an 710065, China., Wang Q; Institute for Hygiene of Ordnance Industry, Xi'an 710065, China., Lu Q; Institute for Hygiene of Ordnance Industry, Xi'an 710065, China., Gao J; Institute for Hygiene of Ordnance Industry, Xi'an 710065, China. Electronic address: 2217265452@qq.com. |
| Πηγή: | Experimental neurology [Exp Neurol] 2025 Dec; Vol. 394, pp. 115427. Date of Electronic Publication: 2025 Aug 12. |
| Τύπος έκδοσης: | Journal Article |
| Γλώσσα: | English |
| Στοιχεία περιοδικού: | Publisher: Academic Press Country of Publication: United States NLM ID: 0370712 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1090-2430 (Electronic) Linking ISSN: 00144886 NLM ISO Abbreviation: Exp Neurol Subsets: MEDLINE |
| Imprint Name(s): | Publication: Orlando Fl : Academic Press Original Publication: New York. |
| Ιατρικοί όροι (MeSH): | Blast Injuries*/pathology , Blast Injuries*/psychology , Blast Injuries*/physiopathology , Behavior, Animal*/physiology , Brain Injuries*/pathology , Brain Injuries*/etiology , High-Energy Shock Waves*/adverse effects, Brain/pathology ; Lung/pathology ; Animals ; Rats ; Male ; Rats, Sprague-Dawley |
| Περίληψη: | To investigate the dynamic response characteristics of personnel injuries caused by blast shock waves under actual working conditions, experimental studies on blast-induced injuries in rats, behavioral experiments post-injury, and pathological examinations were conducted, followed by injury assessments. The results showed that all rats died when the peak overpressure was 0.427 MPa. At a peak overpressure of 0.192 MPa, the rats were assessed as moderately injured. Behavioral tests at 7 and 28 days revealed reduced motor ability and decreased autonomous exploration, with statistically significant results (P < 0.05). Pathological examinations indicated gradual recovery of brain and lung tissues, with only minor residual damage by day 28. At a peak overpressure of 0.125 MPa, the rats were classified as mildly injured. Statistically significant behavioral differences were observed only on day 7 (P < 0.05), and pathological results demonstrated complete recovery of brain and lung tissues by day 28. These findings provide valuable references for future personnel injury assessments and engineering applications. (Copyright © 2025 Elsevier Inc. All rights reserved.) |
| Competing Interests: | Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. |
| Contributed Indexing: | Keywords: Behavioral science; Blast shockwave; Brain injury; Injury assessment; Lung injury |
| Entry Date(s): | Date Created: 20250814 Date Completed: 20250925 Latest Revision: 20250925 |
| Update Code: | 20260130 |
| DOI: | 10.1016/j.expneurol.2025.115427 |
| PMID: | 40812503 |
| Βάση Δεδομένων: | MEDLINE |
| ISSN: | 1090-2430 |
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| DOI: | 10.1016/j.expneurol.2025.115427 |